Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry

Drosophila Polo kinase is the founding member of the Polo-Like Kinase (PLK) family and a master regulator of mitosis and cytokinesis. Here the authors uncover a molecular mechanism for the spatiotemporal regulation of Polo kinase during mitotic entry through a phosphorylation event that triggers nuc...

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Autores principales:	David Kachaner, Damien Garrido, Haytham Mehsen, Karine Normandin, Hugo Lavoie, Vincent Archambault
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/389f2a1bbd0141f2bc14a48f419d8a3f
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spelling	oai:doaj.org-article:389f2a1bbd0141f2bc14a48f419d8a3f2021-12-02T14:41:11ZCoupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry10.1038/s41467-017-01876-82041-1723https://doaj.org/article/389f2a1bbd0141f2bc14a48f419d8a3f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01876-8https://doaj.org/toc/2041-1723Drosophila Polo kinase is the founding member of the Polo-Like Kinase (PLK) family and a master regulator of mitosis and cytokinesis. Here the authors uncover a molecular mechanism for the spatiotemporal regulation of Polo kinase during mitotic entry through a phosphorylation event that triggers nuclear import.David KachanerDamien GarridoHaytham MehsenKarine NormandinHugo LavoieVincent ArchambaultNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Kachaner Damien Garrido Haytham Mehsen Karine Normandin Hugo Lavoie Vincent Archambault Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry
description	Drosophila Polo kinase is the founding member of the Polo-Like Kinase (PLK) family and a master regulator of mitosis and cytokinesis. Here the authors uncover a molecular mechanism for the spatiotemporal regulation of Polo kinase during mitotic entry through a phosphorylation event that triggers nuclear import.
format	article
author	David Kachaner Damien Garrido Haytham Mehsen Karine Normandin Hugo Lavoie Vincent Archambault
author_facet	David Kachaner Damien Garrido Haytham Mehsen Karine Normandin Hugo Lavoie Vincent Archambault
author_sort	David Kachaner
title	Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry
title_short	Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry
title_full	Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry
title_fullStr	Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry
title_full_unstemmed	Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry
title_sort	coupling of polo kinase activation to nuclear localization by a bifunctional nls is required during mitotic entry
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/389f2a1bbd0141f2bc14a48f419d8a3f
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Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry

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