Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry

Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry

Drosophila Polo kinase is the founding member of the Polo-Like Kinase (PLK) family and a master regulator of mitosis and cytokinesis. Here the authors uncover a molecular mechanism for the spatiotemporal regulation of Polo kinase during mitotic entry through a phosphorylation event that triggers nuc...

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Autores principales: David Kachaner, Damien Garrido, Haytham Mehsen, Karine Normandin, Hugo Lavoie, Vincent Archambault
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/389f2a1bbd0141f2bc14a48f419d8a3f
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