Serum iron and risk of nonalcoholic fatty liver disease and advanced hepatic fibrosis in US adults

Abstract Epidemiological evidence on the relationship between serum iron and liver diseases is limited. This study aims to investigate whether serum iron is associated with nonalcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis (AHF). Cross-sectional data for adults aged ≥ 18 years w...

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Autores principales:	Huan-Huan Yang, Guo-Chong Chen, De-Ming Li, Lei Lan, Li-Hua Chen, Jia-Ying Xu, Li-Qiang Qin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/389f62da827841ce997f9401f61f1aea
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spelling	oai:doaj.org-article:389f62da827841ce997f9401f61f1aea2021-12-02T15:45:16ZSerum iron and risk of nonalcoholic fatty liver disease and advanced hepatic fibrosis in US adults10.1038/s41598-021-89991-x2045-2322https://doaj.org/article/389f62da827841ce997f9401f61f1aea2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89991-xhttps://doaj.org/toc/2045-2322Abstract Epidemiological evidence on the relationship between serum iron and liver diseases is limited. This study aims to investigate whether serum iron is associated with nonalcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis (AHF). Cross-sectional data for adults aged ≥ 18 years who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 were analyzed. Odds ratio (ORs) and 95% confidence intervals (CIs) of NAFLD and AHF associated with serum iron were estimated using multivariable logistic regression models. A total of 18,031 males and 18,989 females were included in the analysis. After multivariable adjustment for potential confounders, serum iron was significantly and inversely associated with NAFLD in both genders (P-trend < 0.001) and AHF in females (P-trend = 0.018). Compared to the bottom quartile, those in higher quartiles of serum iron had no significant ORs for AHF in males, but the trend across the quartiles was significant (P-trend = 0.046). In conclusion, higher serum iron level was associated with lower risk of NAFLD in males and females, and with lower risk of AHF in females but not in males. No significant racial/ethnical differences in these associations were observed.Huan-Huan YangGuo-Chong ChenDe-Ming LiLei LanLi-Hua ChenJia-Ying XuLi-Qiang QinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huan-Huan Yang Guo-Chong Chen De-Ming Li Lei Lan Li-Hua Chen Jia-Ying Xu Li-Qiang Qin Serum iron and risk of nonalcoholic fatty liver disease and advanced hepatic fibrosis in US adults
description	Abstract Epidemiological evidence on the relationship between serum iron and liver diseases is limited. This study aims to investigate whether serum iron is associated with nonalcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis (AHF). Cross-sectional data for adults aged ≥ 18 years who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 were analyzed. Odds ratio (ORs) and 95% confidence intervals (CIs) of NAFLD and AHF associated with serum iron were estimated using multivariable logistic regression models. A total of 18,031 males and 18,989 females were included in the analysis. After multivariable adjustment for potential confounders, serum iron was significantly and inversely associated with NAFLD in both genders (P-trend < 0.001) and AHF in females (P-trend = 0.018). Compared to the bottom quartile, those in higher quartiles of serum iron had no significant ORs for AHF in males, but the trend across the quartiles was significant (P-trend = 0.046). In conclusion, higher serum iron level was associated with lower risk of NAFLD in males and females, and with lower risk of AHF in females but not in males. No significant racial/ethnical differences in these associations were observed.
format	article
author	Huan-Huan Yang Guo-Chong Chen De-Ming Li Lei Lan Li-Hua Chen Jia-Ying Xu Li-Qiang Qin
author_facet	Huan-Huan Yang Guo-Chong Chen De-Ming Li Lei Lan Li-Hua Chen Jia-Ying Xu Li-Qiang Qin
author_sort	Huan-Huan Yang
title	Serum iron and risk of nonalcoholic fatty liver disease and advanced hepatic fibrosis in US adults
title_short	Serum iron and risk of nonalcoholic fatty liver disease and advanced hepatic fibrosis in US adults
title_full	Serum iron and risk of nonalcoholic fatty liver disease and advanced hepatic fibrosis in US adults
title_fullStr	Serum iron and risk of nonalcoholic fatty liver disease and advanced hepatic fibrosis in US adults
title_full_unstemmed	Serum iron and risk of nonalcoholic fatty liver disease and advanced hepatic fibrosis in US adults
title_sort	serum iron and risk of nonalcoholic fatty liver disease and advanced hepatic fibrosis in us adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/389f62da827841ce997f9401f61f1aea
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Serum iron and risk of nonalcoholic fatty liver disease and advanced hepatic fibrosis in US adults

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