Cutaneous Adverse Reactions Associated with SARS-CoV-2 Vaccines

Many patients are receiving SARS-CoV-2 vaccinations, which have been associated with a variety of adverse effects. Cutaneous adverse reactions to SARS-CoV-2 vaccinations have been progressively reported, but they have not been reviewed according to their morphological clinical patterns. The objectiv...

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Autores principales:	Francesco Bellinato, Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vaccines COVID-19 cutaneous adverse reaction exanthema safety Medicine R
Acceso en línea:	https://doaj.org/article/389fdc3d0faa42e783bf03fd76d7357c
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spelling	oai:doaj.org-article:389fdc3d0faa42e783bf03fd76d7357c2021-11-25T18:01:56ZCutaneous Adverse Reactions Associated with SARS-CoV-2 Vaccines10.3390/jcm102253442077-0383https://doaj.org/article/389fdc3d0faa42e783bf03fd76d7357c2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5344https://doaj.org/toc/2077-0383Many patients are receiving SARS-CoV-2 vaccinations, which have been associated with a variety of adverse effects. Cutaneous adverse reactions to SARS-CoV-2 vaccinations have been progressively reported, but they have not been reviewed according to their morphological clinical patterns. The objective of this review was to summarize the existing data concerning the cutaneous adverse reactions following SARS-CoV-2 vaccines and group them according to common morphological and pathogenetic patterns. We reviewed the English language literature up to 15 August 2021, using predefined keywords to identify the relevant studies evaluating cutaneous adverse reactions associated with SARS-CoV-2 vaccines. We search for recurrent morphological patterns sharing clinical signs and symptoms and physio-pathological mechanisms. Timing to onset following the first or booster dose of the vaccine, predisposing conditions, therapeutic management, and outcome were also collected. Among the dermatological manifestations associated with SARS-CoV-2 vaccinations, we distinguished: (1) new onset reactions and (2) flares of preexisting dermatoses. The most common were injection site reactions, affecting 30–70% and generally mild or moderate. Small case series or single case reports included filler reactions, exanthemas, vascular lesions, urticaria, eczematous dermatitis, autoimmune bullous reactions, and severe cutaneous adverse reactions. In addition, the exacerbation of chronic immuno-mediated dermatoses (mainly psoriasis and atopic dermatitis) and reactivations of herpes infection were reported. The cutaneous reactions were generally mild, self-limiting, and resembled common cutaneous drug eruptions and/or COVID-19 skin manifestations.Francesco BellinatoMartina MaurelliPaolo GisondiGiampiero GirolomoniMDPI AGarticlevaccinesCOVID-19cutaneous adverse reactionexanthemasafetyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5344, p 5344 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vaccines COVID-19 cutaneous adverse reaction exanthema safety Medicine R
spellingShingle	vaccines COVID-19 cutaneous adverse reaction exanthema safety Medicine R Francesco Bellinato Martina Maurelli Paolo Gisondi Giampiero Girolomoni Cutaneous Adverse Reactions Associated with SARS-CoV-2 Vaccines
description	Many patients are receiving SARS-CoV-2 vaccinations, which have been associated with a variety of adverse effects. Cutaneous adverse reactions to SARS-CoV-2 vaccinations have been progressively reported, but they have not been reviewed according to their morphological clinical patterns. The objective of this review was to summarize the existing data concerning the cutaneous adverse reactions following SARS-CoV-2 vaccines and group them according to common morphological and pathogenetic patterns. We reviewed the English language literature up to 15 August 2021, using predefined keywords to identify the relevant studies evaluating cutaneous adverse reactions associated with SARS-CoV-2 vaccines. We search for recurrent morphological patterns sharing clinical signs and symptoms and physio-pathological mechanisms. Timing to onset following the first or booster dose of the vaccine, predisposing conditions, therapeutic management, and outcome were also collected. Among the dermatological manifestations associated with SARS-CoV-2 vaccinations, we distinguished: (1) new onset reactions and (2) flares of preexisting dermatoses. The most common were injection site reactions, affecting 30–70% and generally mild or moderate. Small case series or single case reports included filler reactions, exanthemas, vascular lesions, urticaria, eczematous dermatitis, autoimmune bullous reactions, and severe cutaneous adverse reactions. In addition, the exacerbation of chronic immuno-mediated dermatoses (mainly psoriasis and atopic dermatitis) and reactivations of herpes infection were reported. The cutaneous reactions were generally mild, self-limiting, and resembled common cutaneous drug eruptions and/or COVID-19 skin manifestations.
format	article
author	Francesco Bellinato Martina Maurelli Paolo Gisondi Giampiero Girolomoni
author_facet	Francesco Bellinato Martina Maurelli Paolo Gisondi Giampiero Girolomoni
author_sort	Francesco Bellinato
title	Cutaneous Adverse Reactions Associated with SARS-CoV-2 Vaccines
title_short	Cutaneous Adverse Reactions Associated with SARS-CoV-2 Vaccines
title_full	Cutaneous Adverse Reactions Associated with SARS-CoV-2 Vaccines
title_fullStr	Cutaneous Adverse Reactions Associated with SARS-CoV-2 Vaccines
title_full_unstemmed	Cutaneous Adverse Reactions Associated with SARS-CoV-2 Vaccines
title_sort	cutaneous adverse reactions associated with sars-cov-2 vaccines
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/389fdc3d0faa42e783bf03fd76d7357c
work_keys_str_mv	AT francescobellinato cutaneousadversereactionsassociatedwithsarscov2vaccines AT martinamaurelli cutaneousadversereactionsassociatedwithsarscov2vaccines AT paologisondi cutaneousadversereactionsassociatedwithsarscov2vaccines AT giampierogirolomoni cutaneousadversereactionsassociatedwithsarscov2vaccines
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Cutaneous Adverse Reactions Associated with SARS-CoV-2 Vaccines

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