Stable Positions of Epigenetically Inherited Centromeres in the Emerging Fungal Pathogen <italic toggle="yes">Candida auris</italic> and Its Relatives

ABSTRACT Candida auris is an emerging fungal pathogen that is thermotolerant and often resistant to standard antifungal treatments. To trace its evolutionary history, the Sanyal lab conducted a comparative genomic study focusing on the positions of centromeres in C. auris and eight other species fro...

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Autor principal:	Laura N. Rusche
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Candida auris centromere epigenetic inheritance Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/38a2f68222864ab596dbbb4ccdad3b69
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spelling	oai:doaj.org-article:38a2f68222864ab596dbbb4ccdad3b692021-11-10T18:37:52ZStable Positions of Epigenetically Inherited Centromeres in the Emerging Fungal Pathogen <italic toggle="yes">Candida auris</italic> and Its Relatives10.1128/mBio.01036-212150-7511https://doaj.org/article/38a2f68222864ab596dbbb4ccdad3b692021-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01036-21https://doaj.org/toc/2150-7511ABSTRACT Candida auris is an emerging fungal pathogen that is thermotolerant and often resistant to standard antifungal treatments. To trace its evolutionary history, the Sanyal lab conducted a comparative genomic study focusing on the positions of centromeres in C. auris and eight other species from the Clavispora/Candida clade of yeasts (A. Narayanan et al., mBio 12:e00905-12, 2021). These researchers discovered that these species possess small regional centromeres that are highly stable, having remained in the same syntenic positions for over 100 million years. This stability is remarkable, given the lack of a conserved sequence underlying the centromeres and the relative ease with which other yeasts form neocentromeres. Thus, this work provides an opportunity to investigate the molecular mechanism of centromere inheritance in a genetically tractable and medically important yeast.Laura N. RuscheAmerican Society for MicrobiologyarticleCandida auriscentromereepigenetic inheritanceMicrobiologyQR1-502ENmBio, Vol 12, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Candida auris centromere epigenetic inheritance Microbiology QR1-502
spellingShingle	Candida auris centromere epigenetic inheritance Microbiology QR1-502 Laura N. Rusche Stable Positions of Epigenetically Inherited Centromeres in the Emerging Fungal Pathogen <italic toggle="yes">Candida auris</italic> and Its Relatives
description	ABSTRACT Candida auris is an emerging fungal pathogen that is thermotolerant and often resistant to standard antifungal treatments. To trace its evolutionary history, the Sanyal lab conducted a comparative genomic study focusing on the positions of centromeres in C. auris and eight other species from the Clavispora/Candida clade of yeasts (A. Narayanan et al., mBio 12:e00905-12, 2021). These researchers discovered that these species possess small regional centromeres that are highly stable, having remained in the same syntenic positions for over 100 million years. This stability is remarkable, given the lack of a conserved sequence underlying the centromeres and the relative ease with which other yeasts form neocentromeres. Thus, this work provides an opportunity to investigate the molecular mechanism of centromere inheritance in a genetically tractable and medically important yeast.
format	article
author	Laura N. Rusche
author_facet	Laura N. Rusche
author_sort	Laura N. Rusche
title	Stable Positions of Epigenetically Inherited Centromeres in the Emerging Fungal Pathogen <italic toggle="yes">Candida auris</italic> and Its Relatives
title_short	Stable Positions of Epigenetically Inherited Centromeres in the Emerging Fungal Pathogen <italic toggle="yes">Candida auris</italic> and Its Relatives
title_full	Stable Positions of Epigenetically Inherited Centromeres in the Emerging Fungal Pathogen <italic toggle="yes">Candida auris</italic> and Its Relatives
title_fullStr	Stable Positions of Epigenetically Inherited Centromeres in the Emerging Fungal Pathogen <italic toggle="yes">Candida auris</italic> and Its Relatives
title_full_unstemmed	Stable Positions of Epigenetically Inherited Centromeres in the Emerging Fungal Pathogen <italic toggle="yes">Candida auris</italic> and Its Relatives
title_sort	stable positions of epigenetically inherited centromeres in the emerging fungal pathogen <italic toggle="yes">candida auris</italic> and its relatives
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/38a2f68222864ab596dbbb4ccdad3b69
work_keys_str_mv	AT lauranrusche stablepositionsofepigeneticallyinheritedcentromeresintheemergingfungalpathogenitalictoggleyescandidaaurisitalicanditsrelatives
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Stable Positions of Epigenetically Inherited Centromeres in the Emerging Fungal Pathogen <italic toggle="yes">Candida auris</italic> and Its Relatives

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