A brief perspective on the diverging theories of lymphatic targeting with colloids

Karthik Siram,1 Gregory Marslin,2 Chellan Vijaya Raghavan,1 Krishnamoorthy Balakumar,1 Habibur Rahman,1 Gregory Franklin3 1Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore, India; 2Centre for the Research and Technology of Agro-Environment and Biological Sciences, University of Minh...

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Autores principales:	Siram K, Marslin G, Raghavan CV, Balakumar K, Rahman H, Franklin G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	lymphatic targeting colloids PEGylation phagocytosis. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/38aaa0e9c9034b45b6f0e197e72ab7bb
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spelling	oai:doaj.org-article:38aaa0e9c9034b45b6f0e197e72ab7bb2021-12-02T01:50:41ZA brief perspective on the diverging theories of lymphatic targeting with colloids1178-2013https://doaj.org/article/38aaa0e9c9034b45b6f0e197e72ab7bb2016-06-01T00:00:00Zhttps://www.dovepress.com/a-brief-perspective-on-the-diverging-theories-of-lymphatic-targeting-w-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Karthik Siram,1 Gregory Marslin,2 Chellan Vijaya Raghavan,1 Krishnamoorthy Balakumar,1 Habibur Rahman,1 Gregory Franklin3 1Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore, India; 2Centre for the Research and Technology of Agro-Environment and Biological Sciences, University of Minho, Braga, Portugal; 3Department of Integrative Plant Biology, Institute of Plant Genetics, Polish Academy of Sciences, Poznan, Poland Abstract: For targeted delivery of colloids to the lymphatic system, the colloids should efficiently reach and remain in the lymphatics for a considerable period of time. As per the current knowledge, diffusion and phagocytosis are the two mechanisms through which colloids reach the lymphatic system. Several parameters including particle size and charge have been shown to affect the direct uptake of colloids by the lymphatic system. Although many researchers attached ligands on the surface of colloids to promote phagocytosis-mediated lymphatic delivery, another school of thought suggests avoidance of phagocytosis by use of carriers like polyethylene glycol (PEG)ylated colloids to impart stealth attributes and evade phagocytosis. In this perspective, we weigh up the paradoxical theories and approaches available in the literature to draw conclusions on the conditions favorable for achieving efficient lymphatic targeting of colloids. Keywords: lymphatic targeting, colloids, PEGylation, phagocytosisSiram KMarslin GRaghavan CVBalakumar KRahman HFranklin GDove Medical Pressarticlelymphatic targetingcolloidsPEGylationphagocytosis.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2867-2872 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	lymphatic targeting colloids PEGylation phagocytosis. Medicine (General) R5-920
spellingShingle	lymphatic targeting colloids PEGylation phagocytosis. Medicine (General) R5-920 Siram K Marslin G Raghavan CV Balakumar K Rahman H Franklin G A brief perspective on the diverging theories of lymphatic targeting with colloids
description	Karthik Siram,1 Gregory Marslin,2 Chellan Vijaya Raghavan,1 Krishnamoorthy Balakumar,1 Habibur Rahman,1 Gregory Franklin3 1Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore, India; 2Centre for the Research and Technology of Agro-Environment and Biological Sciences, University of Minho, Braga, Portugal; 3Department of Integrative Plant Biology, Institute of Plant Genetics, Polish Academy of Sciences, Poznan, Poland Abstract: For targeted delivery of colloids to the lymphatic system, the colloids should efficiently reach and remain in the lymphatics for a considerable period of time. As per the current knowledge, diffusion and phagocytosis are the two mechanisms through which colloids reach the lymphatic system. Several parameters including particle size and charge have been shown to affect the direct uptake of colloids by the lymphatic system. Although many researchers attached ligands on the surface of colloids to promote phagocytosis-mediated lymphatic delivery, another school of thought suggests avoidance of phagocytosis by use of carriers like polyethylene glycol (PEG)ylated colloids to impart stealth attributes and evade phagocytosis. In this perspective, we weigh up the paradoxical theories and approaches available in the literature to draw conclusions on the conditions favorable for achieving efficient lymphatic targeting of colloids. Keywords: lymphatic targeting, colloids, PEGylation, phagocytosis
format	article
author	Siram K Marslin G Raghavan CV Balakumar K Rahman H Franklin G
author_facet	Siram K Marslin G Raghavan CV Balakumar K Rahman H Franklin G
author_sort	Siram K
title	A brief perspective on the diverging theories of lymphatic targeting with colloids
title_short	A brief perspective on the diverging theories of lymphatic targeting with colloids
title_full	A brief perspective on the diverging theories of lymphatic targeting with colloids
title_fullStr	A brief perspective on the diverging theories of lymphatic targeting with colloids
title_full_unstemmed	A brief perspective on the diverging theories of lymphatic targeting with colloids
title_sort	brief perspective on the diverging theories of lymphatic targeting with colloids
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/38aaa0e9c9034b45b6f0e197e72ab7bb
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A brief perspective on the diverging theories of lymphatic targeting with colloids

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