Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia, responsible for the onset of several long-term complications. Recent evidence suggests that cognitive dysfunction represents an emerging complication of DM, but the underlying molecular mechanisms are still obscur...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Francesca Chiara Pignalosa, Antonella Desiderio, Paola Mirra, Cecilia Nigro, Giuseppe Perruolo, Luca Ulianich, Pietro Formisano, Francesco Beguinot, Claudia Miele, Raffaele Napoli, Francesca Fiory
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetes mellitus dopamine cognitive impairment glucotoxicity Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/38ac3270df034e35b3a75fb4defb1bfb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:38ac3270df034e35b3a75fb4defb1bfb
record_format	dspace
spelling	oai:doaj.org-article:38ac3270df034e35b3a75fb4defb1bfb2021-11-25T17:55:44ZDiabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction10.3390/ijms2222123661422-00671661-6596https://doaj.org/article/38ac3270df034e35b3a75fb4defb1bfb2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12366https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia, responsible for the onset of several long-term complications. Recent evidence suggests that cognitive dysfunction represents an emerging complication of DM, but the underlying molecular mechanisms are still obscure. Dopamine (DA), a neurotransmitter essentially known for its relevance in the regulation of behavior and movement, modulates cognitive function, too. Interestingly, alterations of the dopaminergic system have been observed in DM. This review aims to offer a comprehensive overview of the most relevant experimental results assessing DA’s role in cognitive function, highlighting the presence of dopaminergic dysfunction in DM and supporting a role for glucotoxicity in DM-associated dopaminergic dysfunction and cognitive impairment. Several studies confirm a role for DA in cognition both in animal models and in humans. Similarly, significant alterations of the dopaminergic system have been observed in animal models of experimental diabetes and in diabetic patients, too. Evidence is accumulating that advanced glycation end products (AGEs) and their precursor methylglyoxal (MGO) are associated with cognitive impairment and alterations of the dopaminergic system. Further research is needed to clarify the molecular mechanisms linking DM-associated dopaminergic dysfunction and cognitive impairment and to assess the deleterious impact of glucotoxicity.Francesca Chiara PignalosaAntonella DesiderioPaola MirraCecilia NigroGiuseppe PerruoloLuca UlianichPietro FormisanoFrancesco BeguinotClaudia MieleRaffaele NapoliFrancesca FioryMDPI AGarticlediabetes mellitusdopaminecognitive impairmentglucotoxicityBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12366, p 12366 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus dopamine cognitive impairment glucotoxicity Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	diabetes mellitus dopamine cognitive impairment glucotoxicity Biology (General) QH301-705.5 Chemistry QD1-999 Francesca Chiara Pignalosa Antonella Desiderio Paola Mirra Cecilia Nigro Giuseppe Perruolo Luca Ulianich Pietro Formisano Francesco Beguinot Claudia Miele Raffaele Napoli Francesca Fiory Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction
description	Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia, responsible for the onset of several long-term complications. Recent evidence suggests that cognitive dysfunction represents an emerging complication of DM, but the underlying molecular mechanisms are still obscure. Dopamine (DA), a neurotransmitter essentially known for its relevance in the regulation of behavior and movement, modulates cognitive function, too. Interestingly, alterations of the dopaminergic system have been observed in DM. This review aims to offer a comprehensive overview of the most relevant experimental results assessing DA’s role in cognitive function, highlighting the presence of dopaminergic dysfunction in DM and supporting a role for glucotoxicity in DM-associated dopaminergic dysfunction and cognitive impairment. Several studies confirm a role for DA in cognition both in animal models and in humans. Similarly, significant alterations of the dopaminergic system have been observed in animal models of experimental diabetes and in diabetic patients, too. Evidence is accumulating that advanced glycation end products (AGEs) and their precursor methylglyoxal (MGO) are associated with cognitive impairment and alterations of the dopaminergic system. Further research is needed to clarify the molecular mechanisms linking DM-associated dopaminergic dysfunction and cognitive impairment and to assess the deleterious impact of glucotoxicity.
format	article
author	Francesca Chiara Pignalosa Antonella Desiderio Paola Mirra Cecilia Nigro Giuseppe Perruolo Luca Ulianich Pietro Formisano Francesco Beguinot Claudia Miele Raffaele Napoli Francesca Fiory
author_facet	Francesca Chiara Pignalosa Antonella Desiderio Paola Mirra Cecilia Nigro Giuseppe Perruolo Luca Ulianich Pietro Formisano Francesco Beguinot Claudia Miele Raffaele Napoli Francesca Fiory
author_sort	Francesca Chiara Pignalosa
title	Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction
title_short	Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction
title_full	Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction
title_fullStr	Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction
title_full_unstemmed	Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction
title_sort	diabetes and cognitive impairment: a role for glucotoxicity and dopaminergic dysfunction
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/38ac3270df034e35b3a75fb4defb1bfb
work_keys_str_mv	AT francescachiarapignalosa diabetesandcognitiveimpairmentaroleforglucotoxicityanddopaminergicdysfunction AT antonelladesiderio diabetesandcognitiveimpairmentaroleforglucotoxicityanddopaminergicdysfunction AT paolamirra diabetesandcognitiveimpairmentaroleforglucotoxicityanddopaminergicdysfunction AT cecilianigro diabetesandcognitiveimpairmentaroleforglucotoxicityanddopaminergicdysfunction AT giuseppeperruolo diabetesandcognitiveimpairmentaroleforglucotoxicityanddopaminergicdysfunction AT lucaulianich diabetesandcognitiveimpairmentaroleforglucotoxicityanddopaminergicdysfunction AT pietroformisano diabetesandcognitiveimpairmentaroleforglucotoxicityanddopaminergicdysfunction AT francescobeguinot diabetesandcognitiveimpairmentaroleforglucotoxicityanddopaminergicdysfunction AT claudiamiele diabetesandcognitiveimpairmentaroleforglucotoxicityanddopaminergicdysfunction AT raffaelenapoli diabetesandcognitiveimpairmentaroleforglucotoxicityanddopaminergicdysfunction AT francescafiory diabetesandcognitiveimpairmentaroleforglucotoxicityanddopaminergicdysfunction
_version_	1718411794795462656

Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction

Ejemplares similares