Therapeutic Role of Annona muricata Fruit and Bee Venom Against MNU-Induced Breast Cancer in Pregnant Rats and its Complications on the Ovaries

Abd El-Fattah BM El-Beltagy,1 Hassan IH Elsyyad,2 Karoline K Abdelaziz,1 Amira S Madany,1 Mohamed M Elghazaly1 1Zoology Department, Faculty of Science, Damanhour University, Damanhour, Egypt; 2Zoology Department, Faculty of Science, Mansoura University, Mansoura, EgyptCorrespondence: Abd El-Fattah B...

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Autores principales:	El-Beltagy AEFBM, Elsyyad HIH, Abdelaziz KK, Madany AS, Elghazaly MM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	graviola bee venom breast cancer apoptosis ovaries offspring Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/38af765d6e2c4ee2ac8d53884093391c
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spelling	oai:doaj.org-article:38af765d6e2c4ee2ac8d53884093391c2021-12-02T18:34:24ZTherapeutic Role of Annona muricata Fruit and Bee Venom Against MNU-Induced Breast Cancer in Pregnant Rats and its Complications on the Ovaries1179-1314https://doaj.org/article/38af765d6e2c4ee2ac8d53884093391c2021-07-01T00:00:00Zhttps://www.dovepress.com/therapeutic-role-of-annona-muricata-fruit-and-bee-venom-against-mnu-in-peer-reviewed-fulltext-article-BCTThttps://doaj.org/toc/1179-1314Abd El-Fattah BM El-Beltagy,1 Hassan IH Elsyyad,2 Karoline K Abdelaziz,1 Amira S Madany,1 Mohamed M Elghazaly1 1Zoology Department, Faculty of Science, Damanhour University, Damanhour, Egypt; 2Zoology Department, Faculty of Science, Mansoura University, Mansoura, EgyptCorrespondence: Abd El-Fattah BM El-Beltagy Email beltagyaaa@yahoo.comAim: To evaluate the potential therapeutic role of Annona muricata (graviola) fruit and bee venom (BV) against N-methylnitrosourea (MNU)-induced breast cancer in pregnant female rats and complications in the ovaries.Methods: A total of 24 female rats were induced with a single dose of MNU (50 mg/kg body weight). After confirmation of positive tumor marker, female rats were placed with the males for mating. The pregnant rats were randomly divided into four groups (n=6): MNU-induced only (group 1), MNU-induced rats and supplemented with A. muricata 200 mg/kg diet (group 2), MNU-induced and treated with two doses of BV 75 μg/kg (group 3), and MNU-induced and treated with both A. muricata and BV (group 4).Results: In group 1, the breast tissue of mothers revealed pronounced cellular hyperplasia and histopathological signs. Also, the ovarian tissue of mothers and their offspring displayed deleterious histological changes. In groups 2 and 4, histopathological signs and cellular hyperplasia markedly disappeared in breast tissue. However, the histopathological signs induced by MNU in the ovarian tissue reversed to normal in groups 2– 4. Also in groups 2– 4, levels of serum MMP1, NFκB, and TNFα significantly decreased, and serum caspase 3 significantly increased either in mother rats or their offspring compared to the MNU-alone group. Levels of serum MDA significantly decreased; however, levels of serum antioxidants (CAT and SOD) significantly increased in all groups 2– 4 compared to MNU-alone group.Conclusion: A. muricata has a more powerful therapeutic role than BV against MNU-induced breast cancer in rats; however, both have a powerful ameliorative role against ovarian histopathological alterations induced by MNU. Such ameliorative effects of A. muricata and BV are mainly attributed to their antioxidant, anti-inflammatory, and antiproliferative constituents.Keywords: graviola, bee venom, breast cancer, apoptosis, ovaries, offspringEl-Beltagy AEFBMElsyyad HIHAbdelaziz KKMadany ASElghazaly MMDove Medical Pressarticlegraviolabee venombreast cancerapoptosisovariesoffspringNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 13, Pp 431-445 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	graviola bee venom breast cancer apoptosis ovaries offspring Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	graviola bee venom breast cancer apoptosis ovaries offspring Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 El-Beltagy AEFBM Elsyyad HIH Abdelaziz KK Madany AS Elghazaly MM Therapeutic Role of Annona muricata Fruit and Bee Venom Against MNU-Induced Breast Cancer in Pregnant Rats and its Complications on the Ovaries
description	Abd El-Fattah BM El-Beltagy,1 Hassan IH Elsyyad,2 Karoline K Abdelaziz,1 Amira S Madany,1 Mohamed M Elghazaly1 1Zoology Department, Faculty of Science, Damanhour University, Damanhour, Egypt; 2Zoology Department, Faculty of Science, Mansoura University, Mansoura, EgyptCorrespondence: Abd El-Fattah BM El-Beltagy Email beltagyaaa@yahoo.comAim: To evaluate the potential therapeutic role of Annona muricata (graviola) fruit and bee venom (BV) against N-methylnitrosourea (MNU)-induced breast cancer in pregnant female rats and complications in the ovaries.Methods: A total of 24 female rats were induced with a single dose of MNU (50 mg/kg body weight). After confirmation of positive tumor marker, female rats were placed with the males for mating. The pregnant rats were randomly divided into four groups (n=6): MNU-induced only (group 1), MNU-induced rats and supplemented with A. muricata 200 mg/kg diet (group 2), MNU-induced and treated with two doses of BV 75 μg/kg (group 3), and MNU-induced and treated with both A. muricata and BV (group 4).Results: In group 1, the breast tissue of mothers revealed pronounced cellular hyperplasia and histopathological signs. Also, the ovarian tissue of mothers and their offspring displayed deleterious histological changes. In groups 2 and 4, histopathological signs and cellular hyperplasia markedly disappeared in breast tissue. However, the histopathological signs induced by MNU in the ovarian tissue reversed to normal in groups 2– 4. Also in groups 2– 4, levels of serum MMP1, NFκB, and TNFα significantly decreased, and serum caspase 3 significantly increased either in mother rats or their offspring compared to the MNU-alone group. Levels of serum MDA significantly decreased; however, levels of serum antioxidants (CAT and SOD) significantly increased in all groups 2– 4 compared to MNU-alone group.Conclusion: A. muricata has a more powerful therapeutic role than BV against MNU-induced breast cancer in rats; however, both have a powerful ameliorative role against ovarian histopathological alterations induced by MNU. Such ameliorative effects of A. muricata and BV are mainly attributed to their antioxidant, anti-inflammatory, and antiproliferative constituents.Keywords: graviola, bee venom, breast cancer, apoptosis, ovaries, offspring
format	article
author	El-Beltagy AEFBM Elsyyad HIH Abdelaziz KK Madany AS Elghazaly MM
author_facet	El-Beltagy AEFBM Elsyyad HIH Abdelaziz KK Madany AS Elghazaly MM
author_sort	El-Beltagy AEFBM
title	Therapeutic Role of Annona muricata Fruit and Bee Venom Against MNU-Induced Breast Cancer in Pregnant Rats and its Complications on the Ovaries
title_short	Therapeutic Role of Annona muricata Fruit and Bee Venom Against MNU-Induced Breast Cancer in Pregnant Rats and its Complications on the Ovaries
title_full	Therapeutic Role of Annona muricata Fruit and Bee Venom Against MNU-Induced Breast Cancer in Pregnant Rats and its Complications on the Ovaries
title_fullStr	Therapeutic Role of Annona muricata Fruit and Bee Venom Against MNU-Induced Breast Cancer in Pregnant Rats and its Complications on the Ovaries
title_full_unstemmed	Therapeutic Role of Annona muricata Fruit and Bee Venom Against MNU-Induced Breast Cancer in Pregnant Rats and its Complications on the Ovaries
title_sort	therapeutic role of annona muricata fruit and bee venom against mnu-induced breast cancer in pregnant rats and its complications on the ovaries
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/38af765d6e2c4ee2ac8d53884093391c
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Therapeutic Role of Annona muricata Fruit and Bee Venom Against MNU-Induced Breast Cancer in Pregnant Rats and its Complications on the Ovaries

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