The role of backbone hydrogen bonds in the transition state for protein folding of a PDZ domain.

Backbone hydrogen bonds are important for the structure and stability of proteins. However, since conventional site-directed mutagenesis cannot be applied to perturb the backbone, the contribution of these hydrogen bonds in protein folding and stability has been assessed only for a very limited set...

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Autores principales: Søren W Pedersen, Greta Hultqvist, Kristian Strømgaard, Per Jemth
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/38b07bd6bbf847c7ac2c841f2629ba9a
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