P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance

P-bodies form in response to stress and act as sites of mRNA storage and degradation. Here the authors identify the mRNA targets of P-bodies during DNA replication stress, and show that P-body proteins act to prevent toxic accumulation of these target transcripts.

Guardado en:

Detalles Bibliográficos
Autores principales:	Raphael Loll-Krippleber, Grant W. Brown
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/38b91d8a311c4ba5b0dd936cdd11a4b6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:38b91d8a311c4ba5b0dd936cdd11a4b6
record_format	dspace
spelling	oai:doaj.org-article:38b91d8a311c4ba5b0dd936cdd11a4b62021-12-02T15:36:59ZP-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance10.1038/s41467-017-00632-22041-1723https://doaj.org/article/38b91d8a311c4ba5b0dd936cdd11a4b62017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00632-2https://doaj.org/toc/2041-1723P-bodies form in response to stress and act as sites of mRNA storage and degradation. Here the authors identify the mRNA targets of P-bodies during DNA replication stress, and show that P-body proteins act to prevent toxic accumulation of these target transcripts.Raphael Loll-KrippleberGrant W. BrownNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raphael Loll-Krippleber Grant W. Brown P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance
description	P-bodies form in response to stress and act as sites of mRNA storage and degradation. Here the authors identify the mRNA targets of P-bodies during DNA replication stress, and show that P-body proteins act to prevent toxic accumulation of these target transcripts.
format	article
author	Raphael Loll-Krippleber Grant W. Brown
author_facet	Raphael Loll-Krippleber Grant W. Brown
author_sort	Raphael Loll-Krippleber
title	P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance
title_short	P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance
title_full	P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance
title_fullStr	P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance
title_full_unstemmed	P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance
title_sort	p-body proteins regulate transcriptional rewiring to promote dna replication stress resistance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/38b91d8a311c4ba5b0dd936cdd11a4b6
work_keys_str_mv	AT raphaellollkrippleber pbodyproteinsregulatetranscriptionalrewiringtopromotednareplicationstressresistance AT grantwbrown pbodyproteinsregulatetranscriptionalrewiringtopromotednareplicationstressresistance
_version_	1718386283476156416

P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance

Ejemplares similares