Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention

The worldwide outbreak of COVID-19 was caused by a pathogenic virus called Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Therapies against SARS-CoV-2 target the virus or human cells or the immune system. However, therapies based on specific antibodies, such as vaccines and monoclonal...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nikola Gligorijevic, Mirjana Radomirovic, Olgica Nedic, Marija Stojadinovic, Urmila Khulal, Dragana Stanic-Vucinic, Tanja Cirkovic Velickovic
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 polyphenols antiviral effects antiviral targets Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/38ba321dae844dc3ad7729eae3d97965
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:38ba321dae844dc3ad7729eae3d97965
record_format	dspace
spelling	oai:doaj.org-article:38ba321dae844dc3ad7729eae3d979652021-11-25T17:56:07ZMolecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention10.3390/ijms2222123851422-00671661-6596https://doaj.org/article/38ba321dae844dc3ad7729eae3d979652021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12385https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The worldwide outbreak of COVID-19 was caused by a pathogenic virus called Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Therapies against SARS-CoV-2 target the virus or human cells or the immune system. However, therapies based on specific antibodies, such as vaccines and monoclonal antibodies, may become inefficient enough when the virus changes its antigenicity due to mutations. Polyphenols are the major class of bioactive compounds in nature, exerting diverse health effects based on their direct antioxidant activity and their effects in the modulation of intracellular signaling. There are currently numerous clinical trials investigating the effects of polyphenols in prophylaxis and the treatment of COVID-19, from symptomatic, via moderate and severe COVID-19 treatment, to anti-fibrotic treatment in discharged COVID-19 patients. Antiviral activities of polyphenols and their impact on immune system modulation could serve as a solid basis for developing polyphenol-based natural approaches for preventing and treating COVID-19.Nikola GligorijevicMirjana RadomirovicOlgica NedicMarija StojadinovicUrmila KhulalDragana Stanic-VucinicTanja Cirkovic VelickovicMDPI AGarticleSARS-CoV-2polyphenolsantiviral effectsantiviral targetsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12385, p 12385 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 polyphenols antiviral effects antiviral targets Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	SARS-CoV-2 polyphenols antiviral effects antiviral targets Biology (General) QH301-705.5 Chemistry QD1-999 Nikola Gligorijevic Mirjana Radomirovic Olgica Nedic Marija Stojadinovic Urmila Khulal Dragana Stanic-Vucinic Tanja Cirkovic Velickovic Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention
description	The worldwide outbreak of COVID-19 was caused by a pathogenic virus called Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Therapies against SARS-CoV-2 target the virus or human cells or the immune system. However, therapies based on specific antibodies, such as vaccines and monoclonal antibodies, may become inefficient enough when the virus changes its antigenicity due to mutations. Polyphenols are the major class of bioactive compounds in nature, exerting diverse health effects based on their direct antioxidant activity and their effects in the modulation of intracellular signaling. There are currently numerous clinical trials investigating the effects of polyphenols in prophylaxis and the treatment of COVID-19, from symptomatic, via moderate and severe COVID-19 treatment, to anti-fibrotic treatment in discharged COVID-19 patients. Antiviral activities of polyphenols and their impact on immune system modulation could serve as a solid basis for developing polyphenol-based natural approaches for preventing and treating COVID-19.
format	article
author	Nikola Gligorijevic Mirjana Radomirovic Olgica Nedic Marija Stojadinovic Urmila Khulal Dragana Stanic-Vucinic Tanja Cirkovic Velickovic
author_facet	Nikola Gligorijevic Mirjana Radomirovic Olgica Nedic Marija Stojadinovic Urmila Khulal Dragana Stanic-Vucinic Tanja Cirkovic Velickovic
author_sort	Nikola Gligorijevic
title	Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention
title_short	Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention
title_full	Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention
title_fullStr	Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention
title_full_unstemmed	Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention
title_sort	molecular mechanisms of possible action of phenolic compounds in covid-19 protection and prevention
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/38ba321dae844dc3ad7729eae3d97965
work_keys_str_mv	AT nikolagligorijevic molecularmechanismsofpossibleactionofphenoliccompoundsincovid19protectionandprevention AT mirjanaradomirovic molecularmechanismsofpossibleactionofphenoliccompoundsincovid19protectionandprevention AT olgicanedic molecularmechanismsofpossibleactionofphenoliccompoundsincovid19protectionandprevention AT marijastojadinovic molecularmechanismsofpossibleactionofphenoliccompoundsincovid19protectionandprevention AT urmilakhulal molecularmechanismsofpossibleactionofphenoliccompoundsincovid19protectionandprevention AT draganastanicvucinic molecularmechanismsofpossibleactionofphenoliccompoundsincovid19protectionandprevention AT tanjacirkovicvelickovic molecularmechanismsofpossibleactionofphenoliccompoundsincovid19protectionandprevention
_version_	1718411794984206336

Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention

Ejemplares similares