Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma

Nina Muñoz et al. present a novel thermal ablation technique, termed molecularly targeted photothermal ablation (MTPA) that generates hyperthermia specifically within tumor tissue in a clinically-relevant rat model of liver cancer. They further show that MTPA modulates the intratumoral immune profil...

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Autores principales:	Nina M. Muñoz, Crystal Dupuis, Malea Williams, Katherine Dixon, Amanda McWatters, Rony Avritscher, Richard Bouchard, Ahmed Kaseb, Kyle M. Schachtschneider, Arvind Rao, Rahul A. Sheth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/38bb593324754324a9b21f7a12b7af32
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spelling	oai:doaj.org-article:38bb593324754324a9b21f7a12b7af322021-12-02T13:33:58ZMolecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma10.1038/s42003-020-01522-y2399-3642https://doaj.org/article/38bb593324754324a9b21f7a12b7af322020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01522-yhttps://doaj.org/toc/2399-3642Nina Muñoz et al. present a novel thermal ablation technique, termed molecularly targeted photothermal ablation (MTPA) that generates hyperthermia specifically within tumor tissue in a clinically-relevant rat model of liver cancer. They further show that MTPA modulates the intratumoral immune profile toward stronger tumor immunogenicity while reducing the release of oncogenic cytokines relative to conventional ablation techniques.Nina M. MuñozCrystal DupuisMalea WilliamsKatherine DixonAmanda McWattersRony AvritscherRichard BouchardAhmed KasebKyle M. SchachtschneiderArvind RaoRahul A. ShethNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Nina M. Muñoz Crystal Dupuis Malea Williams Katherine Dixon Amanda McWatters Rony Avritscher Richard Bouchard Ahmed Kaseb Kyle M. Schachtschneider Arvind Rao Rahul A. Sheth Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma
description	Nina Muñoz et al. present a novel thermal ablation technique, termed molecularly targeted photothermal ablation (MTPA) that generates hyperthermia specifically within tumor tissue in a clinically-relevant rat model of liver cancer. They further show that MTPA modulates the intratumoral immune profile toward stronger tumor immunogenicity while reducing the release of oncogenic cytokines relative to conventional ablation techniques.
format	article
author	Nina M. Muñoz Crystal Dupuis Malea Williams Katherine Dixon Amanda McWatters Rony Avritscher Richard Bouchard Ahmed Kaseb Kyle M. Schachtschneider Arvind Rao Rahul A. Sheth
author_facet	Nina M. Muñoz Crystal Dupuis Malea Williams Katherine Dixon Amanda McWatters Rony Avritscher Richard Bouchard Ahmed Kaseb Kyle M. Schachtschneider Arvind Rao Rahul A. Sheth
author_sort	Nina M. Muñoz
title	Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma
title_short	Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma
title_full	Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma
title_fullStr	Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma
title_full_unstemmed	Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma
title_sort	molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/38bb593324754324a9b21f7a12b7af32
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_version_	1718392787633700864

Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma

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