Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space

Abstract Microgravity exposure is associated with loss of muscle mass and strength. The E3 ubiquitin ligase MuRF1 plays an integral role in degrading the contractile apparatus of skeletal muscle; MuRF1 null (KO) mice have shown protection in ground-based models of muscle atrophy. In contrast, MuRF1...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Samuel M. Cadena, Yunyu Zhang, Jian Fang, Sophie Brachat, Pia Kuss, Elisa Giorgetti, Louis S. Stodieck, Michaela Kneissel, David J. Glass
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/38bd92eb66384209bb03539a66816b7a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:38bd92eb66384209bb03539a66816b7a
record_format	dspace
spelling	oai:doaj.org-article:38bd92eb66384209bb03539a66816b7a2021-12-02T15:09:57ZSkeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space10.1038/s41598-019-45821-92045-2322https://doaj.org/article/38bd92eb66384209bb03539a66816b7a2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-45821-9https://doaj.org/toc/2045-2322Abstract Microgravity exposure is associated with loss of muscle mass and strength. The E3 ubiquitin ligase MuRF1 plays an integral role in degrading the contractile apparatus of skeletal muscle; MuRF1 null (KO) mice have shown protection in ground-based models of muscle atrophy. In contrast, MuRF1 KO mice subjected to 21 days of microgravity on the International Space Station (ISS) were not protected from muscle atrophy. In a time course experiment microgravity-induced muscle loss on the ISS showed MuRF1 gene expression was not upregulated. A comparison of the soleus transcriptome profiles between spaceflight and a publicly available data set for hindlimb suspension, a claimed surrogate model of microgravity, showed only marginal commonalities between the models. These findings demonstrate spaceflight induced atrophy is unique, and that understanding of effects of space requires study situated beyond the Earth’s mesosphere.Samuel M. CadenaYunyu ZhangJian FangSophie BrachatPia KussElisa GiorgettiLouis S. StodieckMichaela KneisselDavid J. GlassNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Samuel M. Cadena Yunyu Zhang Jian Fang Sophie Brachat Pia Kuss Elisa Giorgetti Louis S. Stodieck Michaela Kneissel David J. Glass Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space
description	Abstract Microgravity exposure is associated with loss of muscle mass and strength. The E3 ubiquitin ligase MuRF1 plays an integral role in degrading the contractile apparatus of skeletal muscle; MuRF1 null (KO) mice have shown protection in ground-based models of muscle atrophy. In contrast, MuRF1 KO mice subjected to 21 days of microgravity on the International Space Station (ISS) were not protected from muscle atrophy. In a time course experiment microgravity-induced muscle loss on the ISS showed MuRF1 gene expression was not upregulated. A comparison of the soleus transcriptome profiles between spaceflight and a publicly available data set for hindlimb suspension, a claimed surrogate model of microgravity, showed only marginal commonalities between the models. These findings demonstrate spaceflight induced atrophy is unique, and that understanding of effects of space requires study situated beyond the Earth’s mesosphere.
format	article
author	Samuel M. Cadena Yunyu Zhang Jian Fang Sophie Brachat Pia Kuss Elisa Giorgetti Louis S. Stodieck Michaela Kneissel David J. Glass
author_facet	Samuel M. Cadena Yunyu Zhang Jian Fang Sophie Brachat Pia Kuss Elisa Giorgetti Louis S. Stodieck Michaela Kneissel David J. Glass
author_sort	Samuel M. Cadena
title	Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space
title_short	Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space
title_full	Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space
title_fullStr	Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space
title_full_unstemmed	Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space
title_sort	skeletal muscle in murf1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/38bd92eb66384209bb03539a66816b7a
work_keys_str_mv	AT samuelmcadena skeletalmuscleinmurf1nullmiceisnotsparedinlowgravityconditionsindicatingatrophyproceedsbyuniquemechanismsinspace AT yunyuzhang skeletalmuscleinmurf1nullmiceisnotsparedinlowgravityconditionsindicatingatrophyproceedsbyuniquemechanismsinspace AT jianfang skeletalmuscleinmurf1nullmiceisnotsparedinlowgravityconditionsindicatingatrophyproceedsbyuniquemechanismsinspace AT sophiebrachat skeletalmuscleinmurf1nullmiceisnotsparedinlowgravityconditionsindicatingatrophyproceedsbyuniquemechanismsinspace AT piakuss skeletalmuscleinmurf1nullmiceisnotsparedinlowgravityconditionsindicatingatrophyproceedsbyuniquemechanismsinspace AT elisagiorgetti skeletalmuscleinmurf1nullmiceisnotsparedinlowgravityconditionsindicatingatrophyproceedsbyuniquemechanismsinspace AT louissstodieck skeletalmuscleinmurf1nullmiceisnotsparedinlowgravityconditionsindicatingatrophyproceedsbyuniquemechanismsinspace AT michaelakneissel skeletalmuscleinmurf1nullmiceisnotsparedinlowgravityconditionsindicatingatrophyproceedsbyuniquemechanismsinspace AT davidjglass skeletalmuscleinmurf1nullmiceisnotsparedinlowgravityconditionsindicatingatrophyproceedsbyuniquemechanismsinspace
_version_	1718387745144963072

Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space

Ejemplares similares