Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration

Current treatments for age-related neovascular macular degeneration (nAMD) suffer from limited efficacy. Here, Zhao et al. show that pharmacological inhibition or genetic deletion of the mineralocorticoid receptor (MR) limits choroidal neovascularisation in rodents, and show in a pilot clinical stud...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Min Zhao, Irmela Mantel, Emmanuelle Gelize, Xinxin Li, Xiaoyue Xie, Alejandro Arboleda, Marie Seminel, Rinath Levy-Boukris, Marilyn Dernigoghossian, Andrea Prunotto, Charlotte Andrieu-Soler, Carlo Rivolta, Jérémie Canonica, Marie-Christine Naud, Sebastian Lechner, Nicolette Farman, Irene Bravo-Osuna, Rocio Herrero-Vanrell, Frederic Jaisser, Francine Behar-Cohen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/38bef37aaba649d6a6734776e59801e9
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:38bef37aaba649d6a6734776e59801e9
record_format dspace
spelling oai:doaj.org-article:38bef37aaba649d6a6734776e59801e92021-12-02T16:57:41ZMineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration10.1038/s41467-018-08125-62041-1723https://doaj.org/article/38bef37aaba649d6a6734776e59801e92019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08125-6https://doaj.org/toc/2041-1723Current treatments for age-related neovascular macular degeneration (nAMD) suffer from limited efficacy. Here, Zhao et al. show that pharmacological inhibition or genetic deletion of the mineralocorticoid receptor (MR) limits choroidal neovascularisation in rodents, and show in a pilot clinical study that targeting the MR pathway may provide clinical benefits in nAMD patiens.Min ZhaoIrmela MantelEmmanuelle GelizeXinxin LiXiaoyue XieAlejandro ArboledaMarie SeminelRinath Levy-BoukrisMarilyn DernigoghossianAndrea PrunottoCharlotte Andrieu-SolerCarlo RivoltaJérémie CanonicaMarie-Christine NaudSebastian LechnerNicolette FarmanIrene Bravo-OsunaRocio Herrero-VanrellFrederic JaisserFrancine Behar-CohenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Min Zhao
Irmela Mantel
Emmanuelle Gelize
Xinxin Li
Xiaoyue Xie
Alejandro Arboleda
Marie Seminel
Rinath Levy-Boukris
Marilyn Dernigoghossian
Andrea Prunotto
Charlotte Andrieu-Soler
Carlo Rivolta
Jérémie Canonica
Marie-Christine Naud
Sebastian Lechner
Nicolette Farman
Irene Bravo-Osuna
Rocio Herrero-Vanrell
Frederic Jaisser
Francine Behar-Cohen
Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration
description Current treatments for age-related neovascular macular degeneration (nAMD) suffer from limited efficacy. Here, Zhao et al. show that pharmacological inhibition or genetic deletion of the mineralocorticoid receptor (MR) limits choroidal neovascularisation in rodents, and show in a pilot clinical study that targeting the MR pathway may provide clinical benefits in nAMD patiens.
format article
author Min Zhao
Irmela Mantel
Emmanuelle Gelize
Xinxin Li
Xiaoyue Xie
Alejandro Arboleda
Marie Seminel
Rinath Levy-Boukris
Marilyn Dernigoghossian
Andrea Prunotto
Charlotte Andrieu-Soler
Carlo Rivolta
Jérémie Canonica
Marie-Christine Naud
Sebastian Lechner
Nicolette Farman
Irene Bravo-Osuna
Rocio Herrero-Vanrell
Frederic Jaisser
Francine Behar-Cohen
author_facet Min Zhao
Irmela Mantel
Emmanuelle Gelize
Xinxin Li
Xiaoyue Xie
Alejandro Arboleda
Marie Seminel
Rinath Levy-Boukris
Marilyn Dernigoghossian
Andrea Prunotto
Charlotte Andrieu-Soler
Carlo Rivolta
Jérémie Canonica
Marie-Christine Naud
Sebastian Lechner
Nicolette Farman
Irene Bravo-Osuna
Rocio Herrero-Vanrell
Frederic Jaisser
Francine Behar-Cohen
author_sort Min Zhao
title Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration
title_short Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration
title_full Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration
title_fullStr Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration
title_full_unstemmed Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration
title_sort mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/38bef37aaba649d6a6734776e59801e9
work_keys_str_mv AT minzhao mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT irmelamantel mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT emmanuellegelize mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT xinxinli mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT xiaoyuexie mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT alejandroarboleda mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT marieseminel mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT rinathlevyboukris mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT marilyndernigoghossian mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT andreaprunotto mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT charlotteandrieusoler mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT carlorivolta mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT jeremiecanonica mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT mariechristinenaud mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT sebastianlechner mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT nicolettefarman mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT irenebravoosuna mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT rocioherrerovanrell mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT fredericjaisser mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
AT francinebeharcohen mineralocorticoidreceptorantagonismlimitsexperimentalchoroidalneovascularizationandstructuralchangesassociatedwithneovascularagerelatedmaculardegeneration
_version_ 1718382495465996288