Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration
Current treatments for age-related neovascular macular degeneration (nAMD) suffer from limited efficacy. Here, Zhao et al. show that pharmacological inhibition or genetic deletion of the mineralocorticoid receptor (MR) limits choroidal neovascularisation in rodents, and show in a pilot clinical stud...
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Nature Portfolio
2019
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oai:doaj.org-article:38bef37aaba649d6a6734776e59801e92021-12-02T16:57:41ZMineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration10.1038/s41467-018-08125-62041-1723https://doaj.org/article/38bef37aaba649d6a6734776e59801e92019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08125-6https://doaj.org/toc/2041-1723Current treatments for age-related neovascular macular degeneration (nAMD) suffer from limited efficacy. Here, Zhao et al. show that pharmacological inhibition or genetic deletion of the mineralocorticoid receptor (MR) limits choroidal neovascularisation in rodents, and show in a pilot clinical study that targeting the MR pathway may provide clinical benefits in nAMD patiens.Min ZhaoIrmela MantelEmmanuelle GelizeXinxin LiXiaoyue XieAlejandro ArboledaMarie SeminelRinath Levy-BoukrisMarilyn DernigoghossianAndrea PrunottoCharlotte Andrieu-SolerCarlo RivoltaJérémie CanonicaMarie-Christine NaudSebastian LechnerNicolette FarmanIrene Bravo-OsunaRocio Herrero-VanrellFrederic JaisserFrancine Behar-CohenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
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Science Q Min Zhao Irmela Mantel Emmanuelle Gelize Xinxin Li Xiaoyue Xie Alejandro Arboleda Marie Seminel Rinath Levy-Boukris Marilyn Dernigoghossian Andrea Prunotto Charlotte Andrieu-Soler Carlo Rivolta Jérémie Canonica Marie-Christine Naud Sebastian Lechner Nicolette Farman Irene Bravo-Osuna Rocio Herrero-Vanrell Frederic Jaisser Francine Behar-Cohen Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration |
description |
Current treatments for age-related neovascular macular degeneration (nAMD) suffer from limited efficacy. Here, Zhao et al. show that pharmacological inhibition or genetic deletion of the mineralocorticoid receptor (MR) limits choroidal neovascularisation in rodents, and show in a pilot clinical study that targeting the MR pathway may provide clinical benefits in nAMD patiens. |
format |
article |
author |
Min Zhao Irmela Mantel Emmanuelle Gelize Xinxin Li Xiaoyue Xie Alejandro Arboleda Marie Seminel Rinath Levy-Boukris Marilyn Dernigoghossian Andrea Prunotto Charlotte Andrieu-Soler Carlo Rivolta Jérémie Canonica Marie-Christine Naud Sebastian Lechner Nicolette Farman Irene Bravo-Osuna Rocio Herrero-Vanrell Frederic Jaisser Francine Behar-Cohen |
author_facet |
Min Zhao Irmela Mantel Emmanuelle Gelize Xinxin Li Xiaoyue Xie Alejandro Arboleda Marie Seminel Rinath Levy-Boukris Marilyn Dernigoghossian Andrea Prunotto Charlotte Andrieu-Soler Carlo Rivolta Jérémie Canonica Marie-Christine Naud Sebastian Lechner Nicolette Farman Irene Bravo-Osuna Rocio Herrero-Vanrell Frederic Jaisser Francine Behar-Cohen |
author_sort |
Min Zhao |
title |
Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration |
title_short |
Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration |
title_full |
Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration |
title_fullStr |
Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration |
title_full_unstemmed |
Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration |
title_sort |
mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/38bef37aaba649d6a6734776e59801e9 |
work_keys_str_mv |
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