An Aging-Related Gene Signature-Based Model for Risk Stratification and Prognosis Prediction in Breast Cancer
Jing Yuan,1,* Fangfang Duan,2,* Wenyu Zhai,3,* Chenge Song,2 Li Wang,2 Wen Xia,2 Xin Hua,2 Zhongyu Yuan,2 Xiwen Bi,2 Jiajia Huang2 1Departments of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/38bfd541424445758e3421cc117e8227 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:38bfd541424445758e3421cc117e8227 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:38bfd541424445758e3421cc117e82272021-11-04T19:00:26ZAn Aging-Related Gene Signature-Based Model for Risk Stratification and Prognosis Prediction in Breast Cancer1179-1411https://doaj.org/article/38bfd541424445758e3421cc117e82272021-11-01T00:00:00Zhttps://www.dovepress.com/an-aging-related-gene-signature-based-model-for-risk-stratification-an-peer-reviewed-fulltext-article-IJWHhttps://doaj.org/toc/1179-1411Jing Yuan,1,* Fangfang Duan,2,* Wenyu Zhai,3,* Chenge Song,2 Li Wang,2 Wen Xia,2 Xin Hua,2 Zhongyu Yuan,2 Xiwen Bi,2 Jiajia Huang2 1Departments of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China; 2Departments of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China; 3Departments of Thoracic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiajia Huang; Xiwen BiDepartment of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, People’s Republic of ChinaEmail huangjiaj@sysucc.org.cn; bixw@sysucc.org.cnBackground: Aging, an inevitable process characterized by functional decline over time, is a significant risk factor for various tumors. However, little is known about aging-related genes (ARGs) in breast cancer (BC). We aimed to explore the potential prognostic role of ARGs and to develop an ARG-based prognosis signature for BC.Methods: RNA-sequencing expression profiles and corresponding clinicopathological data of female patients with BC were obtained from public databases in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). An ARG-based risk signature was constructed in the TCGA cohort based on results of least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analysis, and its prognostic value was further validated in the GSE20685 cohort.Results: A six ARG-based signature, including CLU, DGAT1, MXI1, NFKBI, PIK3CA and PLAU, was developed in the TCGA cohort and significantly stratified patients into low- and high-risk groups. Patients in the former group showed significantly better prognosis than those in the latter. Multivariate Cox regression analysis demonstrated that the ARG risk score was an independent prognostic factor for BC. A predictive nomogram integrating the ARG risk score and three identified factors (age, N- and M-classification) was established in the TCGA cohort and validated in the GSE20685 cohort. Calibration plots showed good consistency between predicted survival probabilities and actual observations.Conclusion: A novel ARG-based risk signature was developed for patients with BC, which can be used for individual prognosis prediction and promoting personalized treatment.Keywords: breast cancer, aging, prognostic signature, risk stratificationYuan JDuan FZhai WSong CWang LXia WHua XYuan ZBi XHuang JDove Medical Pressarticlebreast canceragingprognostic signaturerisk stratificationGynecology and obstetricsRG1-991ENInternational Journal of Women's Health, Vol Volume 13, Pp 1053-1064 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
breast cancer aging prognostic signature risk stratification Gynecology and obstetrics RG1-991 |
| spellingShingle |
breast cancer aging prognostic signature risk stratification Gynecology and obstetrics RG1-991 Yuan J Duan F Zhai W Song C Wang L Xia W Hua X Yuan Z Bi X Huang J An Aging-Related Gene Signature-Based Model for Risk Stratification and Prognosis Prediction in Breast Cancer |
| description |
Jing Yuan,1,* Fangfang Duan,2,* Wenyu Zhai,3,* Chenge Song,2 Li Wang,2 Wen Xia,2 Xin Hua,2 Zhongyu Yuan,2 Xiwen Bi,2 Jiajia Huang2 1Departments of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China; 2Departments of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China; 3Departments of Thoracic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiajia Huang; Xiwen BiDepartment of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, People’s Republic of ChinaEmail huangjiaj@sysucc.org.cn; bixw@sysucc.org.cnBackground: Aging, an inevitable process characterized by functional decline over time, is a significant risk factor for various tumors. However, little is known about aging-related genes (ARGs) in breast cancer (BC). We aimed to explore the potential prognostic role of ARGs and to develop an ARG-based prognosis signature for BC.Methods: RNA-sequencing expression profiles and corresponding clinicopathological data of female patients with BC were obtained from public databases in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). An ARG-based risk signature was constructed in the TCGA cohort based on results of least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analysis, and its prognostic value was further validated in the GSE20685 cohort.Results: A six ARG-based signature, including CLU, DGAT1, MXI1, NFKBI, PIK3CA and PLAU, was developed in the TCGA cohort and significantly stratified patients into low- and high-risk groups. Patients in the former group showed significantly better prognosis than those in the latter. Multivariate Cox regression analysis demonstrated that the ARG risk score was an independent prognostic factor for BC. A predictive nomogram integrating the ARG risk score and three identified factors (age, N- and M-classification) was established in the TCGA cohort and validated in the GSE20685 cohort. Calibration plots showed good consistency between predicted survival probabilities and actual observations.Conclusion: A novel ARG-based risk signature was developed for patients with BC, which can be used for individual prognosis prediction and promoting personalized treatment.Keywords: breast cancer, aging, prognostic signature, risk stratification |
| format |
article |
| author |
Yuan J Duan F Zhai W Song C Wang L Xia W Hua X Yuan Z Bi X Huang J |
| author_facet |
Yuan J Duan F Zhai W Song C Wang L Xia W Hua X Yuan Z Bi X Huang J |
| author_sort |
Yuan J |
| title |
An Aging-Related Gene Signature-Based Model for Risk Stratification and Prognosis Prediction in Breast Cancer |
| title_short |
An Aging-Related Gene Signature-Based Model for Risk Stratification and Prognosis Prediction in Breast Cancer |
| title_full |
An Aging-Related Gene Signature-Based Model for Risk Stratification and Prognosis Prediction in Breast Cancer |
| title_fullStr |
An Aging-Related Gene Signature-Based Model for Risk Stratification and Prognosis Prediction in Breast Cancer |
| title_full_unstemmed |
An Aging-Related Gene Signature-Based Model for Risk Stratification and Prognosis Prediction in Breast Cancer |
| title_sort |
aging-related gene signature-based model for risk stratification and prognosis prediction in breast cancer |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/38bfd541424445758e3421cc117e8227 |
| work_keys_str_mv |
AT yuanj anagingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT duanf anagingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT zhaiw anagingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT songc anagingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT wangl anagingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT xiaw anagingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT huax anagingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT yuanz anagingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT bix anagingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT huangj anagingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT yuanj agingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT duanf agingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT zhaiw agingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT songc agingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT wangl agingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT xiaw agingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT huax agingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT yuanz agingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT bix agingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer AT huangj agingrelatedgenesignaturebasedmodelforriskstratificationandprognosispredictioninbreastcancer |
| _version_ |
1718444641867530240 |