Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study
Non-invasive early prediction of septic acute kidney injury (S-AKI) is still urgent and challenging. Increased Doppler-based renal resistive index (RRI) has been shown to be associated with S-AKI, but its clinical use is limited, which may be explained by the complex effects of systemic circulation....
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Frontiers Media S.A.
2021
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oai:doaj.org-article:38c2c36affb94a6b8cc8d547643776c72021-12-01T22:21:05ZNon-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study2296-858X10.3389/fmed.2021.723837https://doaj.org/article/38c2c36affb94a6b8cc8d547643776c72021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.723837/fullhttps://doaj.org/toc/2296-858XNon-invasive early prediction of septic acute kidney injury (S-AKI) is still urgent and challenging. Increased Doppler-based renal resistive index (RRI) has been shown to be associated with S-AKI, but its clinical use is limited, which may be explained by the complex effects of systemic circulation. Echocardiogram allows non-invasive assessment of systemic circulation, which may provide an effective supplement to RRI. To find the value of RRI combined with echocardiographic parameters in the non-invasive early prediction of S-AKI, we designed this experiment with repeated measurements of ultrasonographic parameters in the early stage of sepsis (3, 6, 12, and 24 h) in cecum ligation and puncture (CLP) rats (divided into AKI and non-AKI groups at 24 h based on serum creatinine), with sham-operated group serving as controls. Our results found that RRI alone could not effectively predict S-AKI, but when combined with echocardiographic parameters (heart rate, left ventricular end-diastolic internal diameter, and left ventricular end-systolic internal diameter), the predictive value was significantly improved, especially in the early stage of sepsis (3 h, AUC: 0.948, 95% CI 0.839–0.992, P < 0.001), and far earlier than the conventional renal function indicators (serum creatinine and blood urea nitrogen), which only significantly elevated at 24 h. Our method showed novel advances and potential in the early detection of S-AKI.Ying ZhangYing ZhangJianing ZhuJianing ZhuChuyue ZhangChuyue ZhangJing XiaoJing XiaoChao LiuChao LiuChao LiuShuo WangShuo WangPing ZhaoPing ZhaoYaqiong ZhuLi WangQiuyang LiYukun LuoYukun LuoFrontiers Media S.A.articlesepsisacute kidney injuryrenal resistive indexechocardiogramultrasonographyMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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DOAJ |
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EN |
| topic |
sepsis acute kidney injury renal resistive index echocardiogram ultrasonography Medicine (General) R5-920 |
| spellingShingle |
sepsis acute kidney injury renal resistive index echocardiogram ultrasonography Medicine (General) R5-920 Ying Zhang Ying Zhang Jianing Zhu Jianing Zhu Chuyue Zhang Chuyue Zhang Jing Xiao Jing Xiao Chao Liu Chao Liu Chao Liu Shuo Wang Shuo Wang Ping Zhao Ping Zhao Yaqiong Zhu Li Wang Qiuyang Li Yukun Luo Yukun Luo Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study |
| description |
Non-invasive early prediction of septic acute kidney injury (S-AKI) is still urgent and challenging. Increased Doppler-based renal resistive index (RRI) has been shown to be associated with S-AKI, but its clinical use is limited, which may be explained by the complex effects of systemic circulation. Echocardiogram allows non-invasive assessment of systemic circulation, which may provide an effective supplement to RRI. To find the value of RRI combined with echocardiographic parameters in the non-invasive early prediction of S-AKI, we designed this experiment with repeated measurements of ultrasonographic parameters in the early stage of sepsis (3, 6, 12, and 24 h) in cecum ligation and puncture (CLP) rats (divided into AKI and non-AKI groups at 24 h based on serum creatinine), with sham-operated group serving as controls. Our results found that RRI alone could not effectively predict S-AKI, but when combined with echocardiographic parameters (heart rate, left ventricular end-diastolic internal diameter, and left ventricular end-systolic internal diameter), the predictive value was significantly improved, especially in the early stage of sepsis (3 h, AUC: 0.948, 95% CI 0.839–0.992, P < 0.001), and far earlier than the conventional renal function indicators (serum creatinine and blood urea nitrogen), which only significantly elevated at 24 h. Our method showed novel advances and potential in the early detection of S-AKI. |
| format |
article |
| author |
Ying Zhang Ying Zhang Jianing Zhu Jianing Zhu Chuyue Zhang Chuyue Zhang Jing Xiao Jing Xiao Chao Liu Chao Liu Chao Liu Shuo Wang Shuo Wang Ping Zhao Ping Zhao Yaqiong Zhu Li Wang Qiuyang Li Yukun Luo Yukun Luo |
| author_facet |
Ying Zhang Ying Zhang Jianing Zhu Jianing Zhu Chuyue Zhang Chuyue Zhang Jing Xiao Jing Xiao Chao Liu Chao Liu Chao Liu Shuo Wang Shuo Wang Ping Zhao Ping Zhao Yaqiong Zhu Li Wang Qiuyang Li Yukun Luo Yukun Luo |
| author_sort |
Ying Zhang |
| title |
Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study |
| title_short |
Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study |
| title_full |
Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study |
| title_fullStr |
Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study |
| title_full_unstemmed |
Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study |
| title_sort |
non-invasive early prediction of septic acute kidney injury by doppler-based renal resistive indexes combined with echocardiographic parameters: an experimental study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/38c2c36affb94a6b8cc8d547643776c7 |
| work_keys_str_mv |
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