Comparison of nucleoside and nucleotide analogs in the recurrence of hepatitis B virus‐related hepatocellular carcinoma after surgical resection: A multicenter study

Abstract Background Antiviral therapy should reduce the recurrence of hepatitis B virus‐related hepatocellular carcinoma (HBV‐related HCC) after surgical resection. However, there is little research on whether various antiviral drugs have different prognostic effects in patients with HBV‐related HCC...

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Autores principales:	Weili Qi, Junyi Shen, Junlong Dai, Youwei Wu, Yu Zhang, Shusheng Leng, Fengwei Gao, Shun Ran, Wei Peng, Xiaoyun Zhang, Tianfu Wen, Chuan Li
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	hepatitis B virus hepatocellular carcinoma nucleos(t)ide analogs recurrence resection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/38c3395a483d4c26aa0047e582866ce7
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spelling	oai:doaj.org-article:38c3395a483d4c26aa0047e582866ce72021-12-01T04:49:15ZComparison of nucleoside and nucleotide analogs in the recurrence of hepatitis B virus‐related hepatocellular carcinoma after surgical resection: A multicenter study2045-763410.1002/cam4.4348https://doaj.org/article/38c3395a483d4c26aa0047e582866ce72021-12-01T00:00:00Zhttps://doi.org/10.1002/cam4.4348https://doaj.org/toc/2045-7634Abstract Background Antiviral therapy should reduce the recurrence of hepatitis B virus‐related hepatocellular carcinoma (HBV‐related HCC) after surgical resection. However, there is little research on whether various antiviral drugs have different prognostic effects in patients with HBV‐related HCC after curative liver resection. The present study compared the effects of nucleotide analog (NtA) and nucleoside analog (NsA) antiviral therapies after surgical resection on the prognosis of HBV‐related HCC. Methods A total of 1303 patients with HBV‐related HCC who received curative hepatectomy at five institutes between April 2014 and April 2019 were retrospectively enrolled and analyzed. Propensity matching analysis was used to compare the outcomes of HCC patients given NsA versus NtA therapy. Subgroup analysis of patients treated with entecavir (ETV) and tenofovir disoproxil fumarate (TDF) was also performed. Results Among 1303 patients, 759 (58.2%) patients developed recurrence, and 460 (35.3%) patients died. Multivariable analyses revealed that NtA therapy significantly decreased the risk of HCC recurrence (hazard ratio [HR], 0.64; 95% confidence interval [CI], 0.51–0.80; p < 0.001) and HCC‐related death (HR, 0.52; 95% CI, 0.36–0.76; p = 0.001) compared to that with NsA therapy. Subgroup analysis showed that TDF treatment was associated with significantly lower rates of HCC recurrence (HR, 0.64; 95% CI, 0.49–0.83; p = 0.001) and death (HR, 0.32; 95% CI, 0.20–0.50; p < 0.001) than ETV treatment. Conclusions Nucleotide analog treatment, but not NsA treatment, significantly reduced the risk of HCC recurrence in patients with HBV‐related HCC and improved overall survival after curative hepatic resection.Weili QiJunyi ShenJunlong DaiYouwei WuYu ZhangShusheng LengFengwei GaoShun RanWei PengXiaoyun ZhangTianfu WenChuan LiWileyarticlehepatitis B virushepatocellular carcinomanucleos(t)ide analogsrecurrenceresectionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 23, Pp 8421-8431 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatitis B virus hepatocellular carcinoma nucleos(t)ide analogs recurrence resection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatitis B virus hepatocellular carcinoma nucleos(t)ide analogs recurrence resection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Weili Qi Junyi Shen Junlong Dai Youwei Wu Yu Zhang Shusheng Leng Fengwei Gao Shun Ran Wei Peng Xiaoyun Zhang Tianfu Wen Chuan Li Comparison of nucleoside and nucleotide analogs in the recurrence of hepatitis B virus‐related hepatocellular carcinoma after surgical resection: A multicenter study
description	Abstract Background Antiviral therapy should reduce the recurrence of hepatitis B virus‐related hepatocellular carcinoma (HBV‐related HCC) after surgical resection. However, there is little research on whether various antiviral drugs have different prognostic effects in patients with HBV‐related HCC after curative liver resection. The present study compared the effects of nucleotide analog (NtA) and nucleoside analog (NsA) antiviral therapies after surgical resection on the prognosis of HBV‐related HCC. Methods A total of 1303 patients with HBV‐related HCC who received curative hepatectomy at five institutes between April 2014 and April 2019 were retrospectively enrolled and analyzed. Propensity matching analysis was used to compare the outcomes of HCC patients given NsA versus NtA therapy. Subgroup analysis of patients treated with entecavir (ETV) and tenofovir disoproxil fumarate (TDF) was also performed. Results Among 1303 patients, 759 (58.2%) patients developed recurrence, and 460 (35.3%) patients died. Multivariable analyses revealed that NtA therapy significantly decreased the risk of HCC recurrence (hazard ratio [HR], 0.64; 95% confidence interval [CI], 0.51–0.80; p < 0.001) and HCC‐related death (HR, 0.52; 95% CI, 0.36–0.76; p = 0.001) compared to that with NsA therapy. Subgroup analysis showed that TDF treatment was associated with significantly lower rates of HCC recurrence (HR, 0.64; 95% CI, 0.49–0.83; p = 0.001) and death (HR, 0.32; 95% CI, 0.20–0.50; p < 0.001) than ETV treatment. Conclusions Nucleotide analog treatment, but not NsA treatment, significantly reduced the risk of HCC recurrence in patients with HBV‐related HCC and improved overall survival after curative hepatic resection.
format	article
author	Weili Qi Junyi Shen Junlong Dai Youwei Wu Yu Zhang Shusheng Leng Fengwei Gao Shun Ran Wei Peng Xiaoyun Zhang Tianfu Wen Chuan Li
author_facet	Weili Qi Junyi Shen Junlong Dai Youwei Wu Yu Zhang Shusheng Leng Fengwei Gao Shun Ran Wei Peng Xiaoyun Zhang Tianfu Wen Chuan Li
author_sort	Weili Qi
title	Comparison of nucleoside and nucleotide analogs in the recurrence of hepatitis B virus‐related hepatocellular carcinoma after surgical resection: A multicenter study
title_short	Comparison of nucleoside and nucleotide analogs in the recurrence of hepatitis B virus‐related hepatocellular carcinoma after surgical resection: A multicenter study
title_full	Comparison of nucleoside and nucleotide analogs in the recurrence of hepatitis B virus‐related hepatocellular carcinoma after surgical resection: A multicenter study
title_fullStr	Comparison of nucleoside and nucleotide analogs in the recurrence of hepatitis B virus‐related hepatocellular carcinoma after surgical resection: A multicenter study
title_full_unstemmed	Comparison of nucleoside and nucleotide analogs in the recurrence of hepatitis B virus‐related hepatocellular carcinoma after surgical resection: A multicenter study
title_sort	comparison of nucleoside and nucleotide analogs in the recurrence of hepatitis b virus‐related hepatocellular carcinoma after surgical resection: a multicenter study
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/38c3395a483d4c26aa0047e582866ce7
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Comparison of nucleoside and nucleotide analogs in the recurrence of hepatitis B virus‐related hepatocellular carcinoma after surgical resection: A multicenter study

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