Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology

Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology

The RNA-induced silencing complex (RISC) represses gene expression via micro-RNA guided mRNA silencing. Here, the authors show that RISC component Argonaute 2 in the liver regulates energy metabolism by inducing microRNAs that cause metabolic disruption and by suppressing protein translation linked...

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Autores principales: Cai Zhang, Joonbae Seo, Kazutoshi Murakami, Esam S. B. Salem, Elise Bernhard, Vishnupriya J. Borra, Kwangmin Choi, Celvie L. Yuan, Calvin C. Chan, Xiaoting Chen, Taosheng Huang, Matthew T. Weirauch, Senad Divanovic, Nathan R. Qi, Hala Einakat Thomas, Carol A. Mercer, Haruhiko Siomi, Takahisa Nakamura
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/38c391e9f41444b882b89e0d90e18efc
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spelling oai:doaj.org-article:38c391e9f41444b882b89e0d90e18efc2021-12-02T14:39:28ZHepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology10.1038/s41467-018-05870-62041-1723https://doaj.org/article/38c391e9f41444b882b89e0d90e18efc2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05870-6https://doaj.org/toc/2041-1723The RNA-induced silencing complex (RISC) represses gene expression via micro-RNA guided mRNA silencing. Here, the authors show that RISC component Argonaute 2 in the liver regulates energy metabolism by inducing microRNAs that cause metabolic disruption and by suppressing protein translation linked to AMPK activation.Cai ZhangJoonbae SeoKazutoshi MurakamiEsam S. B. SalemElise BernhardVishnupriya J. BorraKwangmin ChoiCelvie L. YuanCalvin C. ChanXiaoting ChenTaosheng HuangMatthew T. WeirauchSenad DivanovicNathan R. QiHala Einakat ThomasCarol A. MercerHaruhiko SiomiTakahisa NakamuraNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Cai Zhang
Joonbae Seo
Kazutoshi Murakami
Esam S. B. Salem
Elise Bernhard
Vishnupriya J. Borra
Kwangmin Choi
Celvie L. Yuan
Calvin C. Chan
Xiaoting Chen
Taosheng Huang
Matthew T. Weirauch
Senad Divanovic
Nathan R. Qi
Hala Einakat Thomas
Carol A. Mercer
Haruhiko Siomi
Takahisa Nakamura
Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology
description The RNA-induced silencing complex (RISC) represses gene expression via micro-RNA guided mRNA silencing. Here, the authors show that RISC component Argonaute 2 in the liver regulates energy metabolism by inducing microRNAs that cause metabolic disruption and by suppressing protein translation linked to AMPK activation.
format article
author Cai Zhang
Joonbae Seo
Kazutoshi Murakami
Esam S. B. Salem
Elise Bernhard
Vishnupriya J. Borra
Kwangmin Choi
Celvie L. Yuan
Calvin C. Chan
Xiaoting Chen
Taosheng Huang
Matthew T. Weirauch
Senad Divanovic
Nathan R. Qi
Hala Einakat Thomas
Carol A. Mercer
Haruhiko Siomi
Takahisa Nakamura
author_facet Cai Zhang
Joonbae Seo
Kazutoshi Murakami
Esam S. B. Salem
Elise Bernhard
Vishnupriya J. Borra
Kwangmin Choi
Celvie L. Yuan
Calvin C. Chan
Xiaoting Chen
Taosheng Huang
Matthew T. Weirauch
Senad Divanovic
Nathan R. Qi
Hala Einakat Thomas
Carol A. Mercer
Haruhiko Siomi
Takahisa Nakamura
author_sort Cai Zhang
title Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology
title_short Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology
title_full Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology
title_fullStr Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology
title_full_unstemmed Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology
title_sort hepatic ago2-mediated rna silencing controls energy metabolism linked to ampk activation and obesity-associated pathophysiology
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/38c391e9f41444b882b89e0d90e18efc
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