Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson’s disease

Abstract Transcranial static magnetic field stimulation (tSMS) is a recent low-cost non-invasive brain stimulation technique that decreases cortical excitability in healthy subjects. The objective of the present study was to test the ability of tSMS to modulate cortical excitability in patients with...

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Autores principales:	M. Dileone, M. C. Carrasco-López, J. C. Segundo-Rodriguez, L. Mordillo-Mateos, N. López-Ariztegui, F. Alonso-Frech, M. J. Catalan-Alonso, J. A. Obeso, A. Oliviero, G. Foffani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/38c442814dff41cd881c4d3252687eec
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spelling	oai:doaj.org-article:38c442814dff41cd881c4d3252687eec2021-12-02T15:06:02ZDopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson’s disease10.1038/s41598-017-04254-y2045-2322https://doaj.org/article/38c442814dff41cd881c4d3252687eec2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04254-yhttps://doaj.org/toc/2045-2322Abstract Transcranial static magnetic field stimulation (tSMS) is a recent low-cost non-invasive brain stimulation technique that decreases cortical excitability in healthy subjects. The objective of the present study was to test the ability of tSMS to modulate cortical excitability in patients with Parkinson’s disease. We performed a randomized double-blind sham-controlled cross-over study to assess cortical excitability before and immediately after tSMS (or sham) applied for 10 min to the more affected motor cortex of patients with Parkinson’s disease. Cortical excitability was quantified by the amplitude of motor evoked potentials (MEPs) elicited by single-pulse transcranial magnetic stimulation (TMS). tSMS significantly decreased MEP amplitudes in patients OFF medication (after overnight withdrawal of dopaminergic drugs), but not ON medication (after an acute dose of levodopa). The between-patients variability of tSMS-induced changes was significantly greater ON medication. The variability ON medication could be partly explained by disease progression, i.e. the more advanced the patient, the more likely it was to observe a switch from inhibitory tSMS plasticity OFF medication to paradoxical facilitatory plasticity ON medication. These results suggest that tSMS induces dopamine-dependent changes of cortical excitability in patients with Parkinson’s disease.M. DileoneM. C. Carrasco-LópezJ. C. Segundo-RodriguezL. Mordillo-MateosN. López-ArizteguiF. Alonso-FrechM. J. Catalan-AlonsoJ. A. ObesoA. OlivieroG. FoffaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Dileone M. C. Carrasco-López J. C. Segundo-Rodriguez L. Mordillo-Mateos N. López-Ariztegui F. Alonso-Frech M. J. Catalan-Alonso J. A. Obeso A. Oliviero G. Foffani Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson’s disease
description	Abstract Transcranial static magnetic field stimulation (tSMS) is a recent low-cost non-invasive brain stimulation technique that decreases cortical excitability in healthy subjects. The objective of the present study was to test the ability of tSMS to modulate cortical excitability in patients with Parkinson’s disease. We performed a randomized double-blind sham-controlled cross-over study to assess cortical excitability before and immediately after tSMS (or sham) applied for 10 min to the more affected motor cortex of patients with Parkinson’s disease. Cortical excitability was quantified by the amplitude of motor evoked potentials (MEPs) elicited by single-pulse transcranial magnetic stimulation (TMS). tSMS significantly decreased MEP amplitudes in patients OFF medication (after overnight withdrawal of dopaminergic drugs), but not ON medication (after an acute dose of levodopa). The between-patients variability of tSMS-induced changes was significantly greater ON medication. The variability ON medication could be partly explained by disease progression, i.e. the more advanced the patient, the more likely it was to observe a switch from inhibitory tSMS plasticity OFF medication to paradoxical facilitatory plasticity ON medication. These results suggest that tSMS induces dopamine-dependent changes of cortical excitability in patients with Parkinson’s disease.
format	article
author	M. Dileone M. C. Carrasco-López J. C. Segundo-Rodriguez L. Mordillo-Mateos N. López-Ariztegui F. Alonso-Frech M. J. Catalan-Alonso J. A. Obeso A. Oliviero G. Foffani
author_facet	M. Dileone M. C. Carrasco-López J. C. Segundo-Rodriguez L. Mordillo-Mateos N. López-Ariztegui F. Alonso-Frech M. J. Catalan-Alonso J. A. Obeso A. Oliviero G. Foffani
author_sort	M. Dileone
title	Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson’s disease
title_short	Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson’s disease
title_full	Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson’s disease
title_fullStr	Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson’s disease
title_full_unstemmed	Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson’s disease
title_sort	dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in parkinson’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/38c442814dff41cd881c4d3252687eec
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Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson’s disease

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