Synthesis runs counter to directional folding of a nascent protein domain

In vivo experiments and optical tweezers force-spectroscopy measurements assessing the co-translational folding of the G-domain from bacterial elongation factor G reveal a sequential folding pathway initiating from the C-terminus. These results suggest that protein folding and synthesis proceed in o...

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Autores principales: Xiuqi Chen, Nandakumar Rajasekaran, Kaixian Liu, Christian M. Kaiser
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/38ca3b49ed5244118a3c3656fe58a7a2
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Sumario:In vivo experiments and optical tweezers force-spectroscopy measurements assessing the co-translational folding of the G-domain from bacterial elongation factor G reveal a sequential folding pathway initiating from the C-terminus. These results suggest that protein folding and synthesis proceed in opposite directions.