Synthesis runs counter to directional folding of a nascent protein domain

In vivo experiments and optical tweezers force-spectroscopy measurements assessing the co-translational folding of the G-domain from bacterial elongation factor G reveal a sequential folding pathway initiating from the C-terminus. These results suggest that protein folding and synthesis proceed in o...

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Main Authors:	Xiuqi Chen, Nandakumar Rajasekaran, Kaixian Liu, Christian M. Kaiser
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/38ca3b49ed5244118a3c3656fe58a7a2
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id	oai:doaj.org-article:38ca3b49ed5244118a3c3656fe58a7a2
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spelling	oai:doaj.org-article:38ca3b49ed5244118a3c3656fe58a7a22021-12-02T17:13:19ZSynthesis runs counter to directional folding of a nascent protein domain10.1038/s41467-020-18921-82041-1723https://doaj.org/article/38ca3b49ed5244118a3c3656fe58a7a22020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18921-8https://doaj.org/toc/2041-1723In vivo experiments and optical tweezers force-spectroscopy measurements assessing the co-translational folding of the G-domain from bacterial elongation factor G reveal a sequential folding pathway initiating from the C-terminus. These results suggest that protein folding and synthesis proceed in opposite directions.Xiuqi ChenNandakumar RajasekaranKaixian LiuChristian M. KaiserNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiuqi Chen Nandakumar Rajasekaran Kaixian Liu Christian M. Kaiser Synthesis runs counter to directional folding of a nascent protein domain
description	In vivo experiments and optical tweezers force-spectroscopy measurements assessing the co-translational folding of the G-domain from bacterial elongation factor G reveal a sequential folding pathway initiating from the C-terminus. These results suggest that protein folding and synthesis proceed in opposite directions.
format	article
author	Xiuqi Chen Nandakumar Rajasekaran Kaixian Liu Christian M. Kaiser
author_facet	Xiuqi Chen Nandakumar Rajasekaran Kaixian Liu Christian M. Kaiser
author_sort	Xiuqi Chen
title	Synthesis runs counter to directional folding of a nascent protein domain
title_short	Synthesis runs counter to directional folding of a nascent protein domain
title_full	Synthesis runs counter to directional folding of a nascent protein domain
title_fullStr	Synthesis runs counter to directional folding of a nascent protein domain
title_full_unstemmed	Synthesis runs counter to directional folding of a nascent protein domain
title_sort	synthesis runs counter to directional folding of a nascent protein domain
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/38ca3b49ed5244118a3c3656fe58a7a2
work_keys_str_mv	AT xiuqichen synthesisrunscountertodirectionalfoldingofanascentproteindomain AT nandakumarrajasekaran synthesisrunscountertodirectionalfoldingofanascentproteindomain AT kaixianliu synthesisrunscountertodirectionalfoldingofanascentproteindomain AT christianmkaiser synthesisrunscountertodirectionalfoldingofanascentproteindomain
_version_	1718381313967259648

Synthesis runs counter to directional folding of a nascent protein domain

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