Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis
The vast majority of BRCA1-driven breast cancers derive from luminal progenitor cells but the mechanisms of this lineage specificity are unclear. Here the authors show that dangerous accumulation of DNA-RNA hybrid structures due to RNA polymerase II pausing, occurs specifically in luminal epithelial...
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Nature Portfolio
2017
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oai:doaj.org-article:38cac16b041a40679c30545eb63c37632021-12-02T14:40:48ZAttenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis10.1038/ncomms159082041-1723https://doaj.org/article/38cac16b041a40679c30545eb63c37632017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15908https://doaj.org/toc/2041-1723The vast majority of BRCA1-driven breast cancers derive from luminal progenitor cells but the mechanisms of this lineage specificity are unclear. Here the authors show that dangerous accumulation of DNA-RNA hybrid structures due to RNA polymerase II pausing, occurs specifically in luminal epithelial cells.Xiaowen ZhangHuai-Chin ChiangYao WangChi ZhangSabrina SmithXiayan ZhaoSreejith J. NairJoel MichalekIsmail JatoiMeeghan LautnerBoyce OliverHoward WangAnna PetitTeresa SolerJoan BrunetFrancesca MateoMiguel Angel PujanaElizabeth PoggiKrysta ChaldekasClaudine IsaacsBeth N. PeshkinOscar OchoaFrederic ChedinConstantine TheoharisLu-Zhe SunTyler J. CurielRichard ElledgeVictor X. JinYanfen HuRong LiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Xiaowen Zhang Huai-Chin Chiang Yao Wang Chi Zhang Sabrina Smith Xiayan Zhao Sreejith J. Nair Joel Michalek Ismail Jatoi Meeghan Lautner Boyce Oliver Howard Wang Anna Petit Teresa Soler Joan Brunet Francesca Mateo Miguel Angel Pujana Elizabeth Poggi Krysta Chaldekas Claudine Isaacs Beth N. Peshkin Oscar Ochoa Frederic Chedin Constantine Theoharis Lu-Zhe Sun Tyler J. Curiel Richard Elledge Victor X. Jin Yanfen Hu Rong Li Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis |
| description |
The vast majority of BRCA1-driven breast cancers derive from luminal progenitor cells but the mechanisms of this lineage specificity are unclear. Here the authors show that dangerous accumulation of DNA-RNA hybrid structures due to RNA polymerase II pausing, occurs specifically in luminal epithelial cells. |
| format |
article |
| author |
Xiaowen Zhang Huai-Chin Chiang Yao Wang Chi Zhang Sabrina Smith Xiayan Zhao Sreejith J. Nair Joel Michalek Ismail Jatoi Meeghan Lautner Boyce Oliver Howard Wang Anna Petit Teresa Soler Joan Brunet Francesca Mateo Miguel Angel Pujana Elizabeth Poggi Krysta Chaldekas Claudine Isaacs Beth N. Peshkin Oscar Ochoa Frederic Chedin Constantine Theoharis Lu-Zhe Sun Tyler J. Curiel Richard Elledge Victor X. Jin Yanfen Hu Rong Li |
| author_facet |
Xiaowen Zhang Huai-Chin Chiang Yao Wang Chi Zhang Sabrina Smith Xiayan Zhao Sreejith J. Nair Joel Michalek Ismail Jatoi Meeghan Lautner Boyce Oliver Howard Wang Anna Petit Teresa Soler Joan Brunet Francesca Mateo Miguel Angel Pujana Elizabeth Poggi Krysta Chaldekas Claudine Isaacs Beth N. Peshkin Oscar Ochoa Frederic Chedin Constantine Theoharis Lu-Zhe Sun Tyler J. Curiel Richard Elledge Victor X. Jin Yanfen Hu Rong Li |
| author_sort |
Xiaowen Zhang |
| title |
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis |
| title_short |
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis |
| title_full |
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis |
| title_fullStr |
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis |
| title_full_unstemmed |
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis |
| title_sort |
attenuation of rna polymerase ii pausing mitigates brca1-associated r-loop accumulation and tumorigenesis |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/38cac16b041a40679c30545eb63c3763 |
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