Immunity status of patients with type 1 and 2 diabetes mellitus and pyelonephritis

Aim. To elucidate changes in the immunity status of patients with type 1 and 2 diabetes mellitus (DM) and pyelonephritis (PN). Materials and methods. The study included 48 patients with type 1 and 2 diabetes mellitus and acute pyelonephritis and 15 ones with pyelonephritiswithout DM. Bacteriologic...

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Autores principales:	Sergey Arutyunovich Chakryan, Vil' Mamilovich Timerbulatov, Tatiana Vyacheslavovna Morugova, Gul'nara Fatikhovna Alibaeva
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2010
Materias:	pyelonephritis immunity diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/38cbb3c468e24da0a3394898405fd3db
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spelling	oai:doaj.org-article:38cbb3c468e24da0a3394898405fd3db2021-11-14T09:00:15ZImmunity status of patients with type 1 and 2 diabetes mellitus and pyelonephritis2072-03512072-037810.14341/2072-0351-5679https://doaj.org/article/38cbb3c468e24da0a3394898405fd3db2010-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5679https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To elucidate changes in the immunity status of patients with type 1 and 2 diabetes mellitus (DM) and pyelonephritis (PN). Materials and methods. The study included 48 patients with type 1 and 2 diabetes mellitus and acute pyelonephritis and 15 ones with pyelonephritiswithout DM. Bacteriological study of urine in the acute phase of the disease was supplemented by evaluation of phagocytic activity, NBT test, measurementof circulating immune complexes, T and B-lymphocyte populations and subpopulations (CD3, CD4, CD8, CD16, CD19, CD95), HLA-DR,determination of lymphocyte immunoregulatory index and serum IgA, G, M, E levels. All patients were given identical antibacterial, anti-inflammatory,and detoxication treatment. Results. Patients with DM and PN suffered more pronounced disturbances of phagocytosis, humoral and cellular immunity than those with PN withoutDM. Immunity changes in DM1 and DM2 patients were similar, but the former had smaller phagocytic reserve and lower CD8, CD19, IgM, and IgElevels than the latter. Immunity status in DM1 and DM2 patients with PN was related to the duration of diabetes. Conclusion. Greater changes in the immune system of DM (especially DM1) patients with PN account for the enhanced frequency of upper urinarytract diseases.Sergey Arutyunovich ChakryanVil' Mamilovich TimerbulatovTatiana Vyacheslavovna MorugovaGul'nara Fatikhovna AlibaevaEndocrinology Research Centrearticlepyelonephritisimmunitydiabetes mellitusNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 13, Iss 2, Pp 81-83 (2010)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	pyelonephritis immunity diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	pyelonephritis immunity diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627 Sergey Arutyunovich Chakryan Vil' Mamilovich Timerbulatov Tatiana Vyacheslavovna Morugova Gul'nara Fatikhovna Alibaeva Immunity status of patients with type 1 and 2 diabetes mellitus and pyelonephritis
description	Aim. To elucidate changes in the immunity status of patients with type 1 and 2 diabetes mellitus (DM) and pyelonephritis (PN). Materials and methods. The study included 48 patients with type 1 and 2 diabetes mellitus and acute pyelonephritis and 15 ones with pyelonephritiswithout DM. Bacteriological study of urine in the acute phase of the disease was supplemented by evaluation of phagocytic activity, NBT test, measurementof circulating immune complexes, T and B-lymphocyte populations and subpopulations (CD3, CD4, CD8, CD16, CD19, CD95), HLA-DR,determination of lymphocyte immunoregulatory index and serum IgA, G, M, E levels. All patients were given identical antibacterial, anti-inflammatory,and detoxication treatment. Results. Patients with DM and PN suffered more pronounced disturbances of phagocytosis, humoral and cellular immunity than those with PN withoutDM. Immunity changes in DM1 and DM2 patients were similar, but the former had smaller phagocytic reserve and lower CD8, CD19, IgM, and IgElevels than the latter. Immunity status in DM1 and DM2 patients with PN was related to the duration of diabetes. Conclusion. Greater changes in the immune system of DM (especially DM1) patients with PN account for the enhanced frequency of upper urinarytract diseases.
format	article
author	Sergey Arutyunovich Chakryan Vil' Mamilovich Timerbulatov Tatiana Vyacheslavovna Morugova Gul'nara Fatikhovna Alibaeva
author_facet	Sergey Arutyunovich Chakryan Vil' Mamilovich Timerbulatov Tatiana Vyacheslavovna Morugova Gul'nara Fatikhovna Alibaeva
author_sort	Sergey Arutyunovich Chakryan
title	Immunity status of patients with type 1 and 2 diabetes mellitus and pyelonephritis
title_short	Immunity status of patients with type 1 and 2 diabetes mellitus and pyelonephritis
title_full	Immunity status of patients with type 1 and 2 diabetes mellitus and pyelonephritis
title_fullStr	Immunity status of patients with type 1 and 2 diabetes mellitus and pyelonephritis
title_full_unstemmed	Immunity status of patients with type 1 and 2 diabetes mellitus and pyelonephritis
title_sort	immunity status of patients with type 1 and 2 diabetes mellitus and pyelonephritis
publisher	Endocrinology Research Centre
publishDate	2010
url	https://doaj.org/article/38cbb3c468e24da0a3394898405fd3db
work_keys_str_mv	AT sergeyarutyunovichchakryan immunitystatusofpatientswithtype1and2diabetesmellitusandpyelonephritis AT vilmamilovichtimerbulatov immunitystatusofpatientswithtype1and2diabetesmellitusandpyelonephritis AT tatianavyacheslavovnamorugova immunitystatusofpatientswithtype1and2diabetesmellitusandpyelonephritis AT gulnarafatikhovnaalibaeva immunitystatusofpatientswithtype1and2diabetesmellitusandpyelonephritis
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Immunity status of patients with type 1 and 2 diabetes mellitus and pyelonephritis

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