Identification of drug-specific public TCR driving severe cutaneous adverse reactions
Severe cutaneous adverse reactions (SCAR) is a T cell-mediated, potentially lethal drug hypersensitivity (DH). Here, the authors identify a carbamazepine-specific TCR common among patients with carbamazepine-induced SCAR that confers SCAR-like pathology in mice upon carbamazepine exposure, thereby i...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/38d2c02fdc28404082a384a33f386ffd |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:38d2c02fdc28404082a384a33f386ffd |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:38d2c02fdc28404082a384a33f386ffd2021-12-02T14:35:43ZIdentification of drug-specific public TCR driving severe cutaneous adverse reactions10.1038/s41467-019-11396-22041-1723https://doaj.org/article/38d2c02fdc28404082a384a33f386ffd2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11396-2https://doaj.org/toc/2041-1723Severe cutaneous adverse reactions (SCAR) is a T cell-mediated, potentially lethal drug hypersensitivity (DH). Here, the authors identify a carbamazepine-specific TCR common among patients with carbamazepine-induced SCAR that confers SCAR-like pathology in mice upon carbamazepine exposure, thereby implicating specific TCRs in DH etiology.Ren-You PanMu-Tzu ChuChuang-Wei WangYun-Shien LeeFrancois LemonnierAaron W. MichelsRyan SchutteDavid A. OstrovChun-Bing ChenElizabeth Jane PhillipsSimon Alexander MallalMaja MockenhauptTeresa BellónWichittra TassaneeyakulKatie D. WhiteJean-Claude RoujeauWen-Hung ChungShuen-Iu HungNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ren-You Pan Mu-Tzu Chu Chuang-Wei Wang Yun-Shien Lee Francois Lemonnier Aaron W. Michels Ryan Schutte David A. Ostrov Chun-Bing Chen Elizabeth Jane Phillips Simon Alexander Mallal Maja Mockenhaupt Teresa Bellón Wichittra Tassaneeyakul Katie D. White Jean-Claude Roujeau Wen-Hung Chung Shuen-Iu Hung Identification of drug-specific public TCR driving severe cutaneous adverse reactions |
| description |
Severe cutaneous adverse reactions (SCAR) is a T cell-mediated, potentially lethal drug hypersensitivity (DH). Here, the authors identify a carbamazepine-specific TCR common among patients with carbamazepine-induced SCAR that confers SCAR-like pathology in mice upon carbamazepine exposure, thereby implicating specific TCRs in DH etiology. |
| format |
article |
| author |
Ren-You Pan Mu-Tzu Chu Chuang-Wei Wang Yun-Shien Lee Francois Lemonnier Aaron W. Michels Ryan Schutte David A. Ostrov Chun-Bing Chen Elizabeth Jane Phillips Simon Alexander Mallal Maja Mockenhaupt Teresa Bellón Wichittra Tassaneeyakul Katie D. White Jean-Claude Roujeau Wen-Hung Chung Shuen-Iu Hung |
| author_facet |
Ren-You Pan Mu-Tzu Chu Chuang-Wei Wang Yun-Shien Lee Francois Lemonnier Aaron W. Michels Ryan Schutte David A. Ostrov Chun-Bing Chen Elizabeth Jane Phillips Simon Alexander Mallal Maja Mockenhaupt Teresa Bellón Wichittra Tassaneeyakul Katie D. White Jean-Claude Roujeau Wen-Hung Chung Shuen-Iu Hung |
| author_sort |
Ren-You Pan |
| title |
Identification of drug-specific public TCR driving severe cutaneous adverse reactions |
| title_short |
Identification of drug-specific public TCR driving severe cutaneous adverse reactions |
| title_full |
Identification of drug-specific public TCR driving severe cutaneous adverse reactions |
| title_fullStr |
Identification of drug-specific public TCR driving severe cutaneous adverse reactions |
| title_full_unstemmed |
Identification of drug-specific public TCR driving severe cutaneous adverse reactions |
| title_sort |
identification of drug-specific public tcr driving severe cutaneous adverse reactions |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/38d2c02fdc28404082a384a33f386ffd |
| work_keys_str_mv |
AT renyoupan identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT mutzuchu identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT chuangweiwang identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT yunshienlee identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT francoislemonnier identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT aaronwmichels identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT ryanschutte identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT davidaostrov identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT chunbingchen identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT elizabethjanephillips identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT simonalexandermallal identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT majamockenhaupt identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT teresabellon identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT wichittratassaneeyakul identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT katiedwhite identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT jeanclauderoujeau identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT wenhungchung identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions AT shueniuhung identificationofdrugspecificpublictcrdrivingseverecutaneousadversereactions |
| _version_ |
1718391064800264192 |