Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance

Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance

ABSTRACT Flaviviruses are controlled by adaptive immune responses but are exquisitely sensitive to interferon-stimulated genes (ISGs). How coinfections, particularly simian immunodeficiency viruses (SIVs), that induce robust ISG signatures influence flavivirus clearance and pathogenesis is unclear....

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Auteurs principaux: Carol L. Vinton, Samuel J. Magaziner, Kimberly A. Dowd, Shelly J. Robertson, Emerito Amaro-Carambot, Erik P. Karmele, Alexandra M. Ortiz, Carly E. Starke, Joseph C. Mudd, Stephen S. Whitehead, Sonja M. Best, Theodore C. Pierson, Heather D. Hickman, Jason M. Brenchley
Format: article
Langue:EN
Publié: American Society for Microbiology 2019
Sujets:
SIV
ZIKV
innate immunity
type I interferon
Microbiology
QR1-502
Accès en ligne:https://doaj.org/article/38d4fedb46b448498b0af972c8906ef0
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https://doaj.org/article/38d4fedb46b448498b0af972c8906ef0

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