Discovery of a chemical probe for PRDM9

PRDM9 is a PR domain containing histone methyl transferase which expression is normally restricted to the germline that has also been linked to a number of somatic cancers. Here the authors describe the identification of a small molecule that selectivity inhibits the methyltransferase activity of PR...

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Autores principales:	Abdellah Allali-Hassani, Magdalena M. Szewczyk, Danton Ivanochko, Shawna L. Organ, Jabez Bok, Jessica Sook Yuin Ho, Florence P. H. Gay, Fengling Li, Levi Blazer, Mohammad S. Eram, Levon Halabelian, David Dilworth, Genna M. Luciani, Evelyne Lima-Fernandes, Qin Wu, Peter Loppnau, Nathan Palmer, S. Zakiah A. Talib, Peter J. Brown, Matthieu Schapira, Philipp Kaldis, Ronan C. O’Hagan, Ernesto Guccione, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, John M. Sanders, Solomon D. Kattar, D. Jonathan Bennett, Benjamin Nicholson, Masoud Vedadi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/38d967925aeb49498c5e1209a2983c26
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spelling	oai:doaj.org-article:38d967925aeb49498c5e1209a2983c262021-12-02T15:36:21ZDiscovery of a chemical probe for PRDM910.1038/s41467-019-13652-x2041-1723https://doaj.org/article/38d967925aeb49498c5e1209a2983c262019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13652-xhttps://doaj.org/toc/2041-1723PRDM9 is a PR domain containing histone methyl transferase which expression is normally restricted to the germline that has also been linked to a number of somatic cancers. Here the authors describe the identification of a small molecule that selectivity inhibits the methyltransferase activity of PRDM9 in biochemical and cellular assaysAbdellah Allali-HassaniMagdalena M. SzewczykDanton IvanochkoShawna L. OrganJabez BokJessica Sook Yuin HoFlorence P. H. GayFengling LiLevi BlazerMohammad S. EramLevon HalabelianDavid DilworthGenna M. LucianiEvelyne Lima-FernandesQin WuPeter LoppnauNathan PalmerS. Zakiah A. TalibPeter J. BrownMatthieu SchapiraPhilipp KaldisRonan C. O’HaganErnesto GuccioneDalia Barsyte-LovejoyCheryl H. ArrowsmithJohn M. SandersSolomon D. KattarD. Jonathan BennettBenjamin NicholsonMasoud VedadiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abdellah Allali-Hassani Magdalena M. Szewczyk Danton Ivanochko Shawna L. Organ Jabez Bok Jessica Sook Yuin Ho Florence P. H. Gay Fengling Li Levi Blazer Mohammad S. Eram Levon Halabelian David Dilworth Genna M. Luciani Evelyne Lima-Fernandes Qin Wu Peter Loppnau Nathan Palmer S. Zakiah A. Talib Peter J. Brown Matthieu Schapira Philipp Kaldis Ronan C. O’Hagan Ernesto Guccione Dalia Barsyte-Lovejoy Cheryl H. Arrowsmith John M. Sanders Solomon D. Kattar D. Jonathan Bennett Benjamin Nicholson Masoud Vedadi Discovery of a chemical probe for PRDM9
description	PRDM9 is a PR domain containing histone methyl transferase which expression is normally restricted to the germline that has also been linked to a number of somatic cancers. Here the authors describe the identification of a small molecule that selectivity inhibits the methyltransferase activity of PRDM9 in biochemical and cellular assays
format	article
author	Abdellah Allali-Hassani Magdalena M. Szewczyk Danton Ivanochko Shawna L. Organ Jabez Bok Jessica Sook Yuin Ho Florence P. H. Gay Fengling Li Levi Blazer Mohammad S. Eram Levon Halabelian David Dilworth Genna M. Luciani Evelyne Lima-Fernandes Qin Wu Peter Loppnau Nathan Palmer S. Zakiah A. Talib Peter J. Brown Matthieu Schapira Philipp Kaldis Ronan C. O’Hagan Ernesto Guccione Dalia Barsyte-Lovejoy Cheryl H. Arrowsmith John M. Sanders Solomon D. Kattar D. Jonathan Bennett Benjamin Nicholson Masoud Vedadi
author_facet	Abdellah Allali-Hassani Magdalena M. Szewczyk Danton Ivanochko Shawna L. Organ Jabez Bok Jessica Sook Yuin Ho Florence P. H. Gay Fengling Li Levi Blazer Mohammad S. Eram Levon Halabelian David Dilworth Genna M. Luciani Evelyne Lima-Fernandes Qin Wu Peter Loppnau Nathan Palmer S. Zakiah A. Talib Peter J. Brown Matthieu Schapira Philipp Kaldis Ronan C. O’Hagan Ernesto Guccione Dalia Barsyte-Lovejoy Cheryl H. Arrowsmith John M. Sanders Solomon D. Kattar D. Jonathan Bennett Benjamin Nicholson Masoud Vedadi
author_sort	Abdellah Allali-Hassani
title	Discovery of a chemical probe for PRDM9
title_short	Discovery of a chemical probe for PRDM9
title_full	Discovery of a chemical probe for PRDM9
title_fullStr	Discovery of a chemical probe for PRDM9
title_full_unstemmed	Discovery of a chemical probe for PRDM9
title_sort	discovery of a chemical probe for prdm9
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/38d967925aeb49498c5e1209a2983c26
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Discovery of a chemical probe for PRDM9

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