Epidemiological characteristics of hand, foot, and mouth disease in Shandong, China, 2009–2016

Abstract In the past decade, hand, foot, and mouth disease (HFMD) has posed a serious threat to childhood health in China; however, no epidemiological data from large HFMD epidemics have been described since 2013. In the present study, we described the epidemiological patterns of HFMD in Shandong pr...

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Autores principales:	Jing Wang, Tao Hu, Dapeng Sun, Shujun Ding, Michael J. Carr, Weijia Xing, Shixue Li, Xianjun Wang, Weifeng Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/38db07eeede24d6d9538963ea0f7ea94
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spelling	oai:doaj.org-article:38db07eeede24d6d9538963ea0f7ea942021-12-02T11:40:50ZEpidemiological characteristics of hand, foot, and mouth disease in Shandong, China, 2009–201610.1038/s41598-017-09196-z2045-2322https://doaj.org/article/38db07eeede24d6d9538963ea0f7ea942017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09196-zhttps://doaj.org/toc/2045-2322Abstract In the past decade, hand, foot, and mouth disease (HFMD) has posed a serious threat to childhood health in China; however, no epidemiological data from large HFMD epidemics have been described since 2013. In the present study, we described the epidemiological patterns of HFMD in Shandong province during 2009–2016 from a large number of symptomatic cases (n = 839,483), including >370,000 HFMD cases since 2013. Our results revealed that HFMD activity has remained at a high level and continued to cause annual epidemics in Shandong province from 2013 onwards. Although the incidence rate was significantly higher in urban areas than in rural areas, no significantly higher case-severity and case-fatality rates were found in urban areas. Furthermore, the seventeen cities of Shandong province could be classified into three distinct epidemiological groups according to the different peak times from southwest (inland) to northeast (coastal) regions. Notably, a replacement of the predominant HFMD circulating agent was seen and non-EVA71/Coxsackievirus A16 enteroviruses became dominant in 2013 and 2015, causing approximately 30% of the severe cases. Our study sheds light on the latest epidemiological characteristics of HFMD in Shandong province and should prove helpful for the prevention and control of the disease in Shandong and elsewhere.Jing WangTao HuDapeng SunShujun DingMichael J. CarrWeijia XingShixue LiXianjun WangWeifeng ShiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing Wang Tao Hu Dapeng Sun Shujun Ding Michael J. Carr Weijia Xing Shixue Li Xianjun Wang Weifeng Shi Epidemiological characteristics of hand, foot, and mouth disease in Shandong, China, 2009–2016
description	Abstract In the past decade, hand, foot, and mouth disease (HFMD) has posed a serious threat to childhood health in China; however, no epidemiological data from large HFMD epidemics have been described since 2013. In the present study, we described the epidemiological patterns of HFMD in Shandong province during 2009–2016 from a large number of symptomatic cases (n = 839,483), including >370,000 HFMD cases since 2013. Our results revealed that HFMD activity has remained at a high level and continued to cause annual epidemics in Shandong province from 2013 onwards. Although the incidence rate was significantly higher in urban areas than in rural areas, no significantly higher case-severity and case-fatality rates were found in urban areas. Furthermore, the seventeen cities of Shandong province could be classified into three distinct epidemiological groups according to the different peak times from southwest (inland) to northeast (coastal) regions. Notably, a replacement of the predominant HFMD circulating agent was seen and non-EVA71/Coxsackievirus A16 enteroviruses became dominant in 2013 and 2015, causing approximately 30% of the severe cases. Our study sheds light on the latest epidemiological characteristics of HFMD in Shandong province and should prove helpful for the prevention and control of the disease in Shandong and elsewhere.
format	article
author	Jing Wang Tao Hu Dapeng Sun Shujun Ding Michael J. Carr Weijia Xing Shixue Li Xianjun Wang Weifeng Shi
author_facet	Jing Wang Tao Hu Dapeng Sun Shujun Ding Michael J. Carr Weijia Xing Shixue Li Xianjun Wang Weifeng Shi
author_sort	Jing Wang
title	Epidemiological characteristics of hand, foot, and mouth disease in Shandong, China, 2009–2016
title_short	Epidemiological characteristics of hand, foot, and mouth disease in Shandong, China, 2009–2016
title_full	Epidemiological characteristics of hand, foot, and mouth disease in Shandong, China, 2009–2016
title_fullStr	Epidemiological characteristics of hand, foot, and mouth disease in Shandong, China, 2009–2016
title_full_unstemmed	Epidemiological characteristics of hand, foot, and mouth disease in Shandong, China, 2009–2016
title_sort	epidemiological characteristics of hand, foot, and mouth disease in shandong, china, 2009–2016
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/38db07eeede24d6d9538963ea0f7ea94
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Epidemiological characteristics of hand, foot, and mouth disease in Shandong, China, 2009–2016

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