Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice

Zhong Q Wang,1,2 Yongmei Yu,1,2 Xian H Zhang,1,2 Z Elizabeth Floyd,3 Anik Boudreau,2 Kun Lian,4 William T Cefalu1,21Nutrition and Diabetes Research Laboratory, 2Botanical Research Center, 3Ubiquitin Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lian K, Boudreau A, Floyd ZE, Zhang XH, Yu Y, Wang ZQ, Cefalu WT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/38dd494df8a74e61882a027f31ed0ee4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:38dd494df8a74e61882a027f31ed0ee4
record_format	dspace
spelling	oai:doaj.org-article:38dd494df8a74e61882a027f31ed0ee42021-12-02T02:36:44ZComparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice1176-91141178-2013https://doaj.org/article/38dd494df8a74e61882a027f31ed0ee42012-06-01T00:00:00Zhttp://www.dovepress.com/comparing-the-effects-of-nano-sized-sugarcane-fiber-with-cellulose-and-a10137https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Zhong Q Wang,1,2 Yongmei Yu,1,2 Xian H Zhang,1,2 Z Elizabeth Floyd,3 Anik Boudreau,2 Kun Lian,4 William T Cefalu1,21Nutrition and Diabetes Research Laboratory, 2Botanical Research Center, 3Ubiquitin Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA; 4The Center for Energy and Environmental Studies, Southern University, Baton Rouge, LA, USAAim: To compare the effects of dietary fibers on hepatic cellular signaling in mice.Methods: Mice were randomly divided into four groups (n = 9/group): high-fat diet (HFD) control, cellulose, psyllium, and sugarcane fiber (SCF) groups. All mice were fed a HFD with or without 10% dietary fiber (w/w) for 12 weeks. Body weight, food intake, fasting glucose, and fasting insulin levels were measured. At the end of the study, hepatic fibroblast growth factor (FGF) 21, AMP-activated protein kinase (AMPK) and insulin signaling protein content were determined.Results: Hepatic FGF21 content was significantly lowered, but &beta;Klotho, fibroblast growth factor receptor 1, fibroblast growth factor receptor 3, and peroxisome proliferator-activated receptor alpha proteins were significantly increased in the SCF group compared with those in the HFD group (P &lt; 0.01). SCF supplementation also significantly enhanced insulin and AMPK signaling, as well as decreased hepatic triglyceride and cholesterol in comparison with the HFD mice. The study has shown that dietary fiber, especially SCF, significantly attenuates lipid accumulation in the liver by enhancing hepatic FGF21, insulin, and AMPK signaling in mice fed a HFD.Conclusion: This study suggests that the modulation of gastrointestinal factors by dietary fibers may play a key role in both enhancing hepatic multiple cellular signaling and reducing lipid accumulation.Keywords: dietary fiber, FGF21, insulin signaling, AMPK, GLP-1, PI 3KLian KBoudreau AFloyd ZEZhang XHYu YWang ZQCefalu WTDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 2999-3012 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Lian K Boudreau A Floyd ZE Zhang XH Yu Y Wang ZQ Cefalu WT Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice
description	Zhong Q Wang,1,2 Yongmei Yu,1,2 Xian H Zhang,1,2 Z Elizabeth Floyd,3 Anik Boudreau,2 Kun Lian,4 William T Cefalu1,21Nutrition and Diabetes Research Laboratory, 2Botanical Research Center, 3Ubiquitin Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA; 4The Center for Energy and Environmental Studies, Southern University, Baton Rouge, LA, USAAim: To compare the effects of dietary fibers on hepatic cellular signaling in mice.Methods: Mice were randomly divided into four groups (n = 9/group): high-fat diet (HFD) control, cellulose, psyllium, and sugarcane fiber (SCF) groups. All mice were fed a HFD with or without 10% dietary fiber (w/w) for 12 weeks. Body weight, food intake, fasting glucose, and fasting insulin levels were measured. At the end of the study, hepatic fibroblast growth factor (FGF) 21, AMP-activated protein kinase (AMPK) and insulin signaling protein content were determined.Results: Hepatic FGF21 content was significantly lowered, but &beta;Klotho, fibroblast growth factor receptor 1, fibroblast growth factor receptor 3, and peroxisome proliferator-activated receptor alpha proteins were significantly increased in the SCF group compared with those in the HFD group (P &lt; 0.01). SCF supplementation also significantly enhanced insulin and AMPK signaling, as well as decreased hepatic triglyceride and cholesterol in comparison with the HFD mice. The study has shown that dietary fiber, especially SCF, significantly attenuates lipid accumulation in the liver by enhancing hepatic FGF21, insulin, and AMPK signaling in mice fed a HFD.Conclusion: This study suggests that the modulation of gastrointestinal factors by dietary fibers may play a key role in both enhancing hepatic multiple cellular signaling and reducing lipid accumulation.Keywords: dietary fiber, FGF21, insulin signaling, AMPK, GLP-1, PI 3K
format	article
author	Lian K Boudreau A Floyd ZE Zhang XH Yu Y Wang ZQ Cefalu WT
author_facet	Lian K Boudreau A Floyd ZE Zhang XH Yu Y Wang ZQ Cefalu WT
author_sort	Lian K
title	Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice
title_short	Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice
title_full	Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice
title_fullStr	Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice
title_full_unstemmed	Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice
title_sort	comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/38dd494df8a74e61882a027f31ed0ee4
work_keys_str_mv	AT liank comparingtheeffectsofnanosizedsugarcanefiberwithcelluloseandpsylliumonhepaticcellularsignalinginmice AT boudreaua comparingtheeffectsofnanosizedsugarcanefiberwithcelluloseandpsylliumonhepaticcellularsignalinginmice AT floydze comparingtheeffectsofnanosizedsugarcanefiberwithcelluloseandpsylliumonhepaticcellularsignalinginmice AT zhangxh comparingtheeffectsofnanosizedsugarcanefiberwithcelluloseandpsylliumonhepaticcellularsignalinginmice AT yuy comparingtheeffectsofnanosizedsugarcanefiberwithcelluloseandpsylliumonhepaticcellularsignalinginmice AT wangzq comparingtheeffectsofnanosizedsugarcanefiberwithcelluloseandpsylliumonhepaticcellularsignalinginmice AT cefaluwt comparingtheeffectsofnanosizedsugarcanefiberwithcelluloseandpsylliumonhepaticcellularsignalinginmice
_version_	1718402342523502592

Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice

Ejemplares similares