Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia

Abstract Fibromyalgia (FM) has been associated to an increased processing of somatosensory stimuli, but its generalization to other sensory modalities is under discussion. To clarify this, we studied auditory event-related potentials (AEPs) to stimuli of different intensity in patients with FM and h...

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Autores principales:	N. Samartin-Veiga, A. J. González-Villar, Y. Triñanes, C. Gómez-Perretta, M. T. Carrillo-de-la-Peña
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/38dd947e73fc4f228fda4bb4ebf676bf
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spelling	oai:doaj.org-article:38dd947e73fc4f228fda4bb4ebf676bf2021-12-02T13:58:14ZEffects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia10.1038/s41598-020-78377-02045-2322https://doaj.org/article/38dd947e73fc4f228fda4bb4ebf676bf2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78377-0https://doaj.org/toc/2045-2322Abstract Fibromyalgia (FM) has been associated to an increased processing of somatosensory stimuli, but its generalization to other sensory modalities is under discussion. To clarify this, we studied auditory event-related potentials (AEPs) to stimuli of different intensity in patients with FM and healthy controls (HCs), considering the effects of attention mechanisms and medication. We performed two experiments: In study 1 (n = 50 FM, 60 HCs), the stimuli were presented randomly within the sequence; in study 2 (n = 28 FM, 30 HCs), they were presented in blocks of the same intensity. We analyzed intensity and group effects on N1-P2 amplitude and, only for the FM group, the effect of medication and the correlation between AEPs and clinical variables. Contrary to the expectation, the patients showed a trend of reduced AEPs to the loudest tones (study 1) or no significant differences with the HCs (study 2). Medication with central effects significantly reduced AEPs, while no significant relationships between the N1-P2 amplitude/intensity function and patients’ symptoms were observed. The findings do not provide evidence of augmented auditory processing in FM. Nevertheless, given the observed effect of medication, the role of sensory amplification as an underlying pathophysiological mechanism in fibromyalgia cannot be discarded.N. Samartin-VeigaA. J. González-VillarY. TriñanesC. Gómez-PerrettaM. T. Carrillo-de-la-PeñaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q N. Samartin-Veiga A. J. González-Villar Y. Triñanes C. Gómez-Perretta M. T. Carrillo-de-la-Peña Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia
description	Abstract Fibromyalgia (FM) has been associated to an increased processing of somatosensory stimuli, but its generalization to other sensory modalities is under discussion. To clarify this, we studied auditory event-related potentials (AEPs) to stimuli of different intensity in patients with FM and healthy controls (HCs), considering the effects of attention mechanisms and medication. We performed two experiments: In study 1 (n = 50 FM, 60 HCs), the stimuli were presented randomly within the sequence; in study 2 (n = 28 FM, 30 HCs), they were presented in blocks of the same intensity. We analyzed intensity and group effects on N1-P2 amplitude and, only for the FM group, the effect of medication and the correlation between AEPs and clinical variables. Contrary to the expectation, the patients showed a trend of reduced AEPs to the loudest tones (study 1) or no significant differences with the HCs (study 2). Medication with central effects significantly reduced AEPs, while no significant relationships between the N1-P2 amplitude/intensity function and patients’ symptoms were observed. The findings do not provide evidence of augmented auditory processing in FM. Nevertheless, given the observed effect of medication, the role of sensory amplification as an underlying pathophysiological mechanism in fibromyalgia cannot be discarded.
format	article
author	N. Samartin-Veiga A. J. González-Villar Y. Triñanes C. Gómez-Perretta M. T. Carrillo-de-la-Peña
author_facet	N. Samartin-Veiga A. J. González-Villar Y. Triñanes C. Gómez-Perretta M. T. Carrillo-de-la-Peña
author_sort	N. Samartin-Veiga
title	Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia
title_short	Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia
title_full	Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia
title_fullStr	Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia
title_full_unstemmed	Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia
title_sort	effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/38dd947e73fc4f228fda4bb4ebf676bf
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Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia

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