Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice

Adult hippocampal neurogenesis (AHN) is suppressed by chronic stress. The negative effect of stress is mainly attributed to increased levels of stress hormones (e.g. glucocorticoids, GCs). Exercise enhances AHN, yet it also stimulates GC secretion. To delineate the paradoxical role of GCs, we took t...

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Autores principales:	Tzu-Feng Wang, Sheng-Feng Tsai, Zi-Wei Zhao, Monica Meng-Chun Shih, Chia-Yih Wang, Ting-Ting Yang, Yu-Min Kuo
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	adult hippocampal neurogenesis corticosterone exercise glucocorticoids stress Physiology QP1-981
Acceso en línea:	https://doaj.org/article/38ddc1c5a87347909d5d3b0d206335b8
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spelling	oai:doaj.org-article:38ddc1c5a87347909d5d3b0d206335b82021-11-12T10:09:38ZExercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice0304-49202666-005910.4103/cjp.cjp_39_21https://doaj.org/article/38ddc1c5a87347909d5d3b0d206335b82021-01-01T00:00:00Zhttp://www.cjphysiology.org/article.asp?issn=0304-4920;year=2021;volume=64;issue=4;spage=186;epage=193;aulast=Wanghttps://doaj.org/toc/0304-4920https://doaj.org/toc/2666-0059Adult hippocampal neurogenesis (AHN) is suppressed by chronic stress. The negative effect of stress is mainly attributed to increased levels of stress hormones (e.g. glucocorticoids, GCs). Exercise enhances AHN, yet it also stimulates GC secretion. To delineate the paradoxical role of GCs, we took the advantage of a unique mouse strain (L/L) which exhibits an inert response to stress-induced secretion of GCs to study the role of GCs in exercise-induced AHN. Our results showed that basal corticosterone (CORT), the main GCs in rodents, levels were similar between the L/L mice and wild-type (WT) mice. However, levels of CORT in the L/L mice were barely altered and significantly lower than those of the WT mice during treadmill running (TR). AHN was enhanced by 4 weeks of TR in the WT mice, but not L/L mice. WT mice that received daily injection of CORT to evoke serum CORT levels similar to those during exercise for 4 weeks did not affect AHN, whereas injection with large amount of CORT inhibited AHN. Taken together, our results indicated that exercise-related elevation of CORT participates in exercise-enhanced AHN. CORT alone is not sufficient to elicit AHN and may inhibit AHN if the levels are high.Tzu-Feng WangSheng-Feng TsaiZi-Wei ZhaoMonica Meng-Chun ShihChia-Yih WangTing-Ting YangYu-Min KuoWolters Kluwer Medknow Publicationsarticleadult hippocampal neurogenesiscorticosteroneexerciseglucocorticoidsstressPhysiologyQP1-981ENChinese Journal of Physiology, Vol 64, Iss 4, Pp 186-193 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adult hippocampal neurogenesis corticosterone exercise glucocorticoids stress Physiology QP1-981
spellingShingle	adult hippocampal neurogenesis corticosterone exercise glucocorticoids stress Physiology QP1-981 Tzu-Feng Wang Sheng-Feng Tsai Zi-Wei Zhao Monica Meng-Chun Shih Chia-Yih Wang Ting-Ting Yang Yu-Min Kuo Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice
description	Adult hippocampal neurogenesis (AHN) is suppressed by chronic stress. The negative effect of stress is mainly attributed to increased levels of stress hormones (e.g. glucocorticoids, GCs). Exercise enhances AHN, yet it also stimulates GC secretion. To delineate the paradoxical role of GCs, we took the advantage of a unique mouse strain (L/L) which exhibits an inert response to stress-induced secretion of GCs to study the role of GCs in exercise-induced AHN. Our results showed that basal corticosterone (CORT), the main GCs in rodents, levels were similar between the L/L mice and wild-type (WT) mice. However, levels of CORT in the L/L mice were barely altered and significantly lower than those of the WT mice during treadmill running (TR). AHN was enhanced by 4 weeks of TR in the WT mice, but not L/L mice. WT mice that received daily injection of CORT to evoke serum CORT levels similar to those during exercise for 4 weeks did not affect AHN, whereas injection with large amount of CORT inhibited AHN. Taken together, our results indicated that exercise-related elevation of CORT participates in exercise-enhanced AHN. CORT alone is not sufficient to elicit AHN and may inhibit AHN if the levels are high.
format	article
author	Tzu-Feng Wang Sheng-Feng Tsai Zi-Wei Zhao Monica Meng-Chun Shih Chia-Yih Wang Ting-Ting Yang Yu-Min Kuo
author_facet	Tzu-Feng Wang Sheng-Feng Tsai Zi-Wei Zhao Monica Meng-Chun Shih Chia-Yih Wang Ting-Ting Yang Yu-Min Kuo
author_sort	Tzu-Feng Wang
title	Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice
title_short	Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice
title_full	Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice
title_fullStr	Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice
title_full_unstemmed	Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice
title_sort	exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/38ddc1c5a87347909d5d3b0d206335b8
work_keys_str_mv	AT tzufengwang exerciseinducedincreasesofcorticosteronecontributetoexerciseenhancedadulthippocampalneurogenesisinmice AT shengfengtsai exerciseinducedincreasesofcorticosteronecontributetoexerciseenhancedadulthippocampalneurogenesisinmice AT ziweizhao exerciseinducedincreasesofcorticosteronecontributetoexerciseenhancedadulthippocampalneurogenesisinmice AT monicamengchunshih exerciseinducedincreasesofcorticosteronecontributetoexerciseenhancedadulthippocampalneurogenesisinmice AT chiayihwang exerciseinducedincreasesofcorticosteronecontributetoexerciseenhancedadulthippocampalneurogenesisinmice AT tingtingyang exerciseinducedincreasesofcorticosteronecontributetoexerciseenhancedadulthippocampalneurogenesisinmice AT yuminkuo exerciseinducedincreasesofcorticosteronecontributetoexerciseenhancedadulthippocampalneurogenesisinmice
_version_	1718431041725661184

Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice

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