Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease

To advance our understanding of pathological features associated with Alzheimer’s disease (AD), chemical tools with distinct specificity towards AD targets would be valuable. Here the authors used a structure-mechanism-based design strategy to obtain small molecules as chemical regulators for distin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Michael W. Beck, Jeffrey S. Derrick, Richard A. Kerr, Shin Bi Oh, Woo Jong Cho, Shin Jung C. Lee, Yonghwan Ji, Jiyeon Han, Zahra Aliakbar Tehrani, Nayoung Suh, Sujeong Kim, Scott D. Larsen, Kwang S. Kim, Joo-Yong Lee, Brandon T. Ruotolo, Mi Hee Lim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/38e022ffa1474e819049faf03deff89d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:38e022ffa1474e819049faf03deff89d
record_format	dspace
spelling	oai:doaj.org-article:38e022ffa1474e819049faf03deff89d2021-12-02T16:58:22ZStructure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease10.1038/ncomms131152041-1723https://doaj.org/article/38e022ffa1474e819049faf03deff89d2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13115https://doaj.org/toc/2041-1723To advance our understanding of pathological features associated with Alzheimer’s disease (AD), chemical tools with distinct specificity towards AD targets would be valuable. Here the authors used a structure-mechanism-based design strategy to obtain small molecules as chemical regulators for distinct pathological factors linked to AD pathology.Michael W. BeckJeffrey S. DerrickRichard A. KerrShin Bi OhWoo Jong ChoShin Jung C. LeeYonghwan JiJiyeon HanZahra Aliakbar TehraniNayoung SuhSujeong KimScott D. LarsenKwang S. KimJoo-Yong LeeBrandon T. RuotoloMi Hee LimNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael W. Beck Jeffrey S. Derrick Richard A. Kerr Shin Bi Oh Woo Jong Cho Shin Jung C. Lee Yonghwan Ji Jiyeon Han Zahra Aliakbar Tehrani Nayoung Suh Sujeong Kim Scott D. Larsen Kwang S. Kim Joo-Yong Lee Brandon T. Ruotolo Mi Hee Lim Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease
description	To advance our understanding of pathological features associated with Alzheimer’s disease (AD), chemical tools with distinct specificity towards AD targets would be valuable. Here the authors used a structure-mechanism-based design strategy to obtain small molecules as chemical regulators for distinct pathological factors linked to AD pathology.
format	article
author	Michael W. Beck Jeffrey S. Derrick Richard A. Kerr Shin Bi Oh Woo Jong Cho Shin Jung C. Lee Yonghwan Ji Jiyeon Han Zahra Aliakbar Tehrani Nayoung Suh Sujeong Kim Scott D. Larsen Kwang S. Kim Joo-Yong Lee Brandon T. Ruotolo Mi Hee Lim
author_facet	Michael W. Beck Jeffrey S. Derrick Richard A. Kerr Shin Bi Oh Woo Jong Cho Shin Jung C. Lee Yonghwan Ji Jiyeon Han Zahra Aliakbar Tehrani Nayoung Suh Sujeong Kim Scott D. Larsen Kwang S. Kim Joo-Yong Lee Brandon T. Ruotolo Mi Hee Lim
author_sort	Michael W. Beck
title	Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease
title_short	Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease
title_full	Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease
title_fullStr	Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease
title_full_unstemmed	Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease
title_sort	structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in alzheimer’s disease
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/38e022ffa1474e819049faf03deff89d
work_keys_str_mv	AT michaelwbeck structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT jeffreysderrick structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT richardakerr structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT shinbioh structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT woojongcho structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT shinjungclee structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT yonghwanji structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT jiyeonhan structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT zahraaliakbartehrani structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT nayoungsuh structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT sujeongkim structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT scottdlarsen structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT kwangskim structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT jooyonglee structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT brandontruotolo structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease AT miheelim structuremechanismbasedengineeringofchemicalregulatorstargetingdistinctpathologicalfactorsinalzheimersdisease
_version_	1718382319888236544

Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease

Ejemplares similares