Metabolomics of <i>Pseudomonas aeruginosa</i> Treated by Atmospheric-Pressure Cold Plasma

With increasing drug resistance of <i>Pseudomonas aeruginosa</i>, a new sterilization method is needed. Plasma has been shown to be an effective method of sterilization, but no researchers have studied the effect of plasma on bacterial metabolism. In this paper, we studied the emission s...

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Autores principales:	Dehui Xu, Xinying Zhang, Jin Zhang, Rui Feng, Shuai Wang, Yanjie Yang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Pseudomonas aeruginosa</i> GC-TOF-MS mass spectrometry emission spectrum metabolism Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/38e0ed031e794522b65d631115c2673c
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spelling	oai:doaj.org-article:38e0ed031e794522b65d631115c2673c2021-11-25T16:30:48ZMetabolomics of <i>Pseudomonas aeruginosa</i> Treated by Atmospheric-Pressure Cold Plasma10.3390/app1122105272076-3417https://doaj.org/article/38e0ed031e794522b65d631115c2673c2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10527https://doaj.org/toc/2076-3417With increasing drug resistance of <i>Pseudomonas aeruginosa</i>, a new sterilization method is needed. Plasma has been shown to be an effective method of sterilization, but no researchers have studied the effect of plasma on bacterial metabolism. In this paper, we studied the emission spectrum, liquid phase active particles, and other physical and chemical properties of a portable plasma device. <i>Pseudomonas aeruginosa</i> were then treated with activated water generated by surface plasma discharge. Using gas chromatography time-of-flight mass spectrometry (GC-TOF-MS) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, we obtained the differential metabolite pathways. The results showed that, after plasma activated water treatment, the carbohydrate metabolism of the bacteria was inhibited and the metabolic processes of protein and amino acid decomposition were enhanced. Therefore, water activated by atmospheric-pressure cold plasma can significantly change bacterial metabolites, thus promoting bacterial death.Dehui XuXinying ZhangJin ZhangRui FengShuai WangYanjie YangMDPI AGarticle<i>Pseudomonas aeruginosa</i>GC-TOF-MS mass spectrometryemission spectrummetabolismTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10527, p 10527 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Pseudomonas aeruginosa</i> GC-TOF-MS mass spectrometry emission spectrum metabolism Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	<i>Pseudomonas aeruginosa</i> GC-TOF-MS mass spectrometry emission spectrum metabolism Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Dehui Xu Xinying Zhang Jin Zhang Rui Feng Shuai Wang Yanjie Yang Metabolomics of <i>Pseudomonas aeruginosa</i> Treated by Atmospheric-Pressure Cold Plasma
description	With increasing drug resistance of <i>Pseudomonas aeruginosa</i>, a new sterilization method is needed. Plasma has been shown to be an effective method of sterilization, but no researchers have studied the effect of plasma on bacterial metabolism. In this paper, we studied the emission spectrum, liquid phase active particles, and other physical and chemical properties of a portable plasma device. <i>Pseudomonas aeruginosa</i> were then treated with activated water generated by surface plasma discharge. Using gas chromatography time-of-flight mass spectrometry (GC-TOF-MS) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, we obtained the differential metabolite pathways. The results showed that, after plasma activated water treatment, the carbohydrate metabolism of the bacteria was inhibited and the metabolic processes of protein and amino acid decomposition were enhanced. Therefore, water activated by atmospheric-pressure cold plasma can significantly change bacterial metabolites, thus promoting bacterial death.
format	article
author	Dehui Xu Xinying Zhang Jin Zhang Rui Feng Shuai Wang Yanjie Yang
author_facet	Dehui Xu Xinying Zhang Jin Zhang Rui Feng Shuai Wang Yanjie Yang
author_sort	Dehui Xu
title	Metabolomics of <i>Pseudomonas aeruginosa</i> Treated by Atmospheric-Pressure Cold Plasma
title_short	Metabolomics of <i>Pseudomonas aeruginosa</i> Treated by Atmospheric-Pressure Cold Plasma
title_full	Metabolomics of <i>Pseudomonas aeruginosa</i> Treated by Atmospheric-Pressure Cold Plasma
title_fullStr	Metabolomics of <i>Pseudomonas aeruginosa</i> Treated by Atmospheric-Pressure Cold Plasma
title_full_unstemmed	Metabolomics of <i>Pseudomonas aeruginosa</i> Treated by Atmospheric-Pressure Cold Plasma
title_sort	metabolomics of <i>pseudomonas aeruginosa</i> treated by atmospheric-pressure cold plasma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/38e0ed031e794522b65d631115c2673c
work_keys_str_mv	AT dehuixu metabolomicsofipseudomonasaeruginosaitreatedbyatmosphericpressurecoldplasma AT xinyingzhang metabolomicsofipseudomonasaeruginosaitreatedbyatmosphericpressurecoldplasma AT jinzhang metabolomicsofipseudomonasaeruginosaitreatedbyatmosphericpressurecoldplasma AT ruifeng metabolomicsofipseudomonasaeruginosaitreatedbyatmosphericpressurecoldplasma AT shuaiwang metabolomicsofipseudomonasaeruginosaitreatedbyatmosphericpressurecoldplasma AT yanjieyang metabolomicsofipseudomonasaeruginosaitreatedbyatmosphericpressurecoldplasma
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Metabolomics of <i>Pseudomonas aeruginosa</i> Treated by Atmospheric-Pressure Cold Plasma

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