Automated percent mammographic density, mammographic texture variation, and risk of breast cancer: a nested case-control study

Abstract Percent mammographic density (PMD) is a strong breast cancer risk factor, however, other mammographic features, such as V, the standard deviation (SD) of pixel intensity, may be associated with risk. We assessed whether PMD, automated PMD (APD), and V, yielded independent associations with...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Erica T. Warner, Megan S. Rice, Oana A. Zeleznik, Erin E. Fowler, Divya Murthy, Celine M. Vachon, Kimberly A. Bertrand, Bernard A. Rosner, John Heine, Rulla M. Tamimi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/38e65c2a56f14278945713b23d59b86a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:38e65c2a56f14278945713b23d59b86a
record_format	dspace
spelling	oai:doaj.org-article:38e65c2a56f14278945713b23d59b86a2021-12-02T15:02:54ZAutomated percent mammographic density, mammographic texture variation, and risk of breast cancer: a nested case-control study10.1038/s41523-021-00272-22374-4677https://doaj.org/article/38e65c2a56f14278945713b23d59b86a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00272-2https://doaj.org/toc/2374-4677Abstract Percent mammographic density (PMD) is a strong breast cancer risk factor, however, other mammographic features, such as V, the standard deviation (SD) of pixel intensity, may be associated with risk. We assessed whether PMD, automated PMD (APD), and V, yielded independent associations with breast cancer risk. We included 1900 breast cancer cases and 3921 matched controls from the Nurses’ Health Study (NHS) and the NHSII. Using digitized film mammograms, we estimated PMD using a computer-assisted thresholding technique. APD and V were determined using an automated computer algorithm. We used logistic regression to generate odds ratios (ORs) and 95% confidence intervals (CIs). Median time from mammogram to diagnosis was 4.1 years (interquartile range: 1.6–6.8 years). PMD (OR per SD:1.52, 95% CI: 1.42, 1.63), APD (OR per SD:1.32, 95% CI: 1.24, 1.41), and V (OR per SD:1.32, 95% CI: 1.24, 1.40) were positively associated with breast cancer risk. Associations for APD were attenuated but remained statistically significant after mutual adjustment for PMD or V. Women in the highest quartile of both APD and V (OR vs Q1/Q1: 2.49, 95% CI: 2.02, 3.06), or PMD and V (OR vs Q1/Q1: 3.57, 95% CI: 2.79, 4.58) had increased breast cancer risk. An automated method of PMD assessment is feasible and yields similar, but somewhat weaker, estimates to a manual measure. PMD, APD and V are each independently, positively associated with breast cancer risk. Women with dense breasts and greater texture variation are at the highest relative risk of breast cancer.Erica T. WarnerMegan S. RiceOana A. ZeleznikErin E. FowlerDivya MurthyCeline M. VachonKimberly A. BertrandBernard A. RosnerJohn HeineRulla M. TamimiNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Erica T. Warner Megan S. Rice Oana A. Zeleznik Erin E. Fowler Divya Murthy Celine M. Vachon Kimberly A. Bertrand Bernard A. Rosner John Heine Rulla M. Tamimi Automated percent mammographic density, mammographic texture variation, and risk of breast cancer: a nested case-control study
description	Abstract Percent mammographic density (PMD) is a strong breast cancer risk factor, however, other mammographic features, such as V, the standard deviation (SD) of pixel intensity, may be associated with risk. We assessed whether PMD, automated PMD (APD), and V, yielded independent associations with breast cancer risk. We included 1900 breast cancer cases and 3921 matched controls from the Nurses’ Health Study (NHS) and the NHSII. Using digitized film mammograms, we estimated PMD using a computer-assisted thresholding technique. APD and V were determined using an automated computer algorithm. We used logistic regression to generate odds ratios (ORs) and 95% confidence intervals (CIs). Median time from mammogram to diagnosis was 4.1 years (interquartile range: 1.6–6.8 years). PMD (OR per SD:1.52, 95% CI: 1.42, 1.63), APD (OR per SD:1.32, 95% CI: 1.24, 1.41), and V (OR per SD:1.32, 95% CI: 1.24, 1.40) were positively associated with breast cancer risk. Associations for APD were attenuated but remained statistically significant after mutual adjustment for PMD or V. Women in the highest quartile of both APD and V (OR vs Q1/Q1: 2.49, 95% CI: 2.02, 3.06), or PMD and V (OR vs Q1/Q1: 3.57, 95% CI: 2.79, 4.58) had increased breast cancer risk. An automated method of PMD assessment is feasible and yields similar, but somewhat weaker, estimates to a manual measure. PMD, APD and V are each independently, positively associated with breast cancer risk. Women with dense breasts and greater texture variation are at the highest relative risk of breast cancer.
format	article
author	Erica T. Warner Megan S. Rice Oana A. Zeleznik Erin E. Fowler Divya Murthy Celine M. Vachon Kimberly A. Bertrand Bernard A. Rosner John Heine Rulla M. Tamimi
author_facet	Erica T. Warner Megan S. Rice Oana A. Zeleznik Erin E. Fowler Divya Murthy Celine M. Vachon Kimberly A. Bertrand Bernard A. Rosner John Heine Rulla M. Tamimi
author_sort	Erica T. Warner
title	Automated percent mammographic density, mammographic texture variation, and risk of breast cancer: a nested case-control study
title_short	Automated percent mammographic density, mammographic texture variation, and risk of breast cancer: a nested case-control study
title_full	Automated percent mammographic density, mammographic texture variation, and risk of breast cancer: a nested case-control study
title_fullStr	Automated percent mammographic density, mammographic texture variation, and risk of breast cancer: a nested case-control study
title_full_unstemmed	Automated percent mammographic density, mammographic texture variation, and risk of breast cancer: a nested case-control study
title_sort	automated percent mammographic density, mammographic texture variation, and risk of breast cancer: a nested case-control study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/38e65c2a56f14278945713b23d59b86a
work_keys_str_mv	AT ericatwarner automatedpercentmammographicdensitymammographictexturevariationandriskofbreastcanceranestedcasecontrolstudy AT megansrice automatedpercentmammographicdensitymammographictexturevariationandriskofbreastcanceranestedcasecontrolstudy AT oanaazeleznik automatedpercentmammographicdensitymammographictexturevariationandriskofbreastcanceranestedcasecontrolstudy AT erinefowler automatedpercentmammographicdensitymammographictexturevariationandriskofbreastcanceranestedcasecontrolstudy AT divyamurthy automatedpercentmammographicdensitymammographictexturevariationandriskofbreastcanceranestedcasecontrolstudy AT celinemvachon automatedpercentmammographicdensitymammographictexturevariationandriskofbreastcanceranestedcasecontrolstudy AT kimberlyabertrand automatedpercentmammographicdensitymammographictexturevariationandriskofbreastcanceranestedcasecontrolstudy AT bernardarosner automatedpercentmammographicdensitymammographictexturevariationandriskofbreastcanceranestedcasecontrolstudy AT johnheine automatedpercentmammographicdensitymammographictexturevariationandriskofbreastcanceranestedcasecontrolstudy AT rullamtamimi automatedpercentmammographicdensitymammographictexturevariationandriskofbreastcanceranestedcasecontrolstudy
_version_	1718389071034712064

Automated percent mammographic density, mammographic texture variation, and risk of breast cancer: a nested case-control study

Ejemplares similares