Early-Life Iron Deficiency Anemia Programs the Hippocampal Epigenomic Landscape

Iron deficiency (ID) anemia is the foremost micronutrient deficiency worldwide, affecting around 40% of pregnant women and young children. ID during the prenatal and early postnatal periods has a pronounced effect on neurodevelopment, resulting in long-term effects such as cognitive impairment and i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Amanda K. Barks, Shirelle X. Liu, Michael K. Georgieff, Timothy C. Hallstrom, Phu V. Tran
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	perinatal iron deficiency neurodevelopment epigenetics JARIDs TETs cognition Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/38e76bbf21414a4aa88fdbc41102cf1f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:38e76bbf21414a4aa88fdbc41102cf1f
record_format	dspace
spelling	oai:doaj.org-article:38e76bbf21414a4aa88fdbc41102cf1f2021-11-25T18:34:42ZEarly-Life Iron Deficiency Anemia Programs the Hippocampal Epigenomic Landscape10.3390/nu131138572072-6643https://doaj.org/article/38e76bbf21414a4aa88fdbc41102cf1f2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3857https://doaj.org/toc/2072-6643Iron deficiency (ID) anemia is the foremost micronutrient deficiency worldwide, affecting around 40% of pregnant women and young children. ID during the prenatal and early postnatal periods has a pronounced effect on neurodevelopment, resulting in long-term effects such as cognitive impairment and increased risk for neuropsychiatric disorders. Treatment of ID has been complicated as it does not always resolve the long-lasting neurodevelopmental deficits. In animal models, developmental ID results in abnormal hippocampal structure and function associated with dysregulation of genes involved in neurotransmission and synaptic plasticity. Dysregulation of these genes is a likely proximate cause of the life-long deficits that follow developmental ID. However, a direct functional link between iron and gene dysregulation has yet to be elucidated. Iron-dependent epigenetic modifications are one mechanism by which ID could alter gene expression across the lifespan. The jumonji and AT-rich interaction domain-containing (JARID) protein and the Ten-Eleven Translocation (TET) proteins are two families of iron-dependent epigenetic modifiers that play critical roles during neural development by establishing proper gene regulation during critical periods of brain development. Therefore, JARIDs and TETs can contribute to the iron-mediated epigenetic mechanisms by which early-life ID directly causes stable changes in gene regulation across the life span.Amanda K. BarksShirelle X. LiuMichael K. GeorgieffTimothy C. HallstromPhu V. TranMDPI AGarticleperinatal iron deficiencyneurodevelopmentepigeneticsJARIDsTETscognitionNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3857, p 3857 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	perinatal iron deficiency neurodevelopment epigenetics JARIDs TETs cognition Nutrition. Foods and food supply TX341-641
spellingShingle	perinatal iron deficiency neurodevelopment epigenetics JARIDs TETs cognition Nutrition. Foods and food supply TX341-641 Amanda K. Barks Shirelle X. Liu Michael K. Georgieff Timothy C. Hallstrom Phu V. Tran Early-Life Iron Deficiency Anemia Programs the Hippocampal Epigenomic Landscape
description	Iron deficiency (ID) anemia is the foremost micronutrient deficiency worldwide, affecting around 40% of pregnant women and young children. ID during the prenatal and early postnatal periods has a pronounced effect on neurodevelopment, resulting in long-term effects such as cognitive impairment and increased risk for neuropsychiatric disorders. Treatment of ID has been complicated as it does not always resolve the long-lasting neurodevelopmental deficits. In animal models, developmental ID results in abnormal hippocampal structure and function associated with dysregulation of genes involved in neurotransmission and synaptic plasticity. Dysregulation of these genes is a likely proximate cause of the life-long deficits that follow developmental ID. However, a direct functional link between iron and gene dysregulation has yet to be elucidated. Iron-dependent epigenetic modifications are one mechanism by which ID could alter gene expression across the lifespan. The jumonji and AT-rich interaction domain-containing (JARID) protein and the Ten-Eleven Translocation (TET) proteins are two families of iron-dependent epigenetic modifiers that play critical roles during neural development by establishing proper gene regulation during critical periods of brain development. Therefore, JARIDs and TETs can contribute to the iron-mediated epigenetic mechanisms by which early-life ID directly causes stable changes in gene regulation across the life span.
format	article
author	Amanda K. Barks Shirelle X. Liu Michael K. Georgieff Timothy C. Hallstrom Phu V. Tran
author_facet	Amanda K. Barks Shirelle X. Liu Michael K. Georgieff Timothy C. Hallstrom Phu V. Tran
author_sort	Amanda K. Barks
title	Early-Life Iron Deficiency Anemia Programs the Hippocampal Epigenomic Landscape
title_short	Early-Life Iron Deficiency Anemia Programs the Hippocampal Epigenomic Landscape
title_full	Early-Life Iron Deficiency Anemia Programs the Hippocampal Epigenomic Landscape
title_fullStr	Early-Life Iron Deficiency Anemia Programs the Hippocampal Epigenomic Landscape
title_full_unstemmed	Early-Life Iron Deficiency Anemia Programs the Hippocampal Epigenomic Landscape
title_sort	early-life iron deficiency anemia programs the hippocampal epigenomic landscape
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/38e76bbf21414a4aa88fdbc41102cf1f
work_keys_str_mv	AT amandakbarks earlylifeirondeficiencyanemiaprogramsthehippocampalepigenomiclandscape AT shirellexliu earlylifeirondeficiencyanemiaprogramsthehippocampalepigenomiclandscape AT michaelkgeorgieff earlylifeirondeficiencyanemiaprogramsthehippocampalepigenomiclandscape AT timothychallstrom earlylifeirondeficiencyanemiaprogramsthehippocampalepigenomiclandscape AT phuvtran earlylifeirondeficiencyanemiaprogramsthehippocampalepigenomiclandscape
_version_	1718410945453096960

Early-Life Iron Deficiency Anemia Programs the Hippocampal Epigenomic Landscape

Ejemplares similares