Dynamics of sperm antibody levels in adolescents with left-sided varicocele

Varicocele means a varicose vein of the spermatic cord, being among the most common disorders diagnosed in childhood and adolescence, which suggests a high risk for infertility. Varicocele is considered an additional factor for immune-dependent infertility which results from damaged hemato-testicula...

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Autores principales:	S. V. Pichugova, I. V. Rybina, Ya. B. Beikin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2020
Materias:	varicocele adolescents sperm antibodies infertility varicocelectomy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/38e9ec660f944ef9913e4aff212cb279
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spelling	oai:doaj.org-article:38e9ec660f944ef9913e4aff212cb2792021-11-18T08:03:50ZDynamics of sperm antibody levels in adolescents with left-sided varicocele1563-06252313-741X10.15789/1563-0625-DOS-1873https://doaj.org/article/38e9ec660f944ef9913e4aff212cb2792020-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1873https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XVaricocele means a varicose vein of the spermatic cord, being among the most common disorders diagnosed in childhood and adolescence, which suggests a high risk for infertility. Varicocele is considered an additional factor for immune-dependent infertility which results from damaged hemato-testicular barrier due to venous blood stasis, hyperthermia, testicular ischemia. Our objective was to determine levels of the sperm antibodies in serum and ejaculate in adolescents with left-sided varicocele, in order to assess the changing levels of sperm antibodies in blood serum at different ages during the postoperative period, depending on the degree of varicocele. For adolescents with left-sided varicocele and without varicocele, the serum levels of sperm antibodies were determined annually at the age of 14 to 17 years, as well as registration of sperm antibodies titer in seminal fluid at the age of 17 years. The levels of sperm antibodies in blood serum were traced in dynamics for the main group and comparison group, also comparing the groups with different degrees of varicocele, like as the patients before and after surgical varicocele correction. We did not reveal increased levels of the sperm antibodies over reference values in any subject under study. The level changes of sperm antibodies in serum showed an increase in these indexes at the age of 15-16 years in adolescents of both groups with a trend for a decrease in the comparison group by 17 years of age, however, without such tendency in the main group. No significant differences were found in the levels of sperm antibodies in blood serum depending on the degree of varicocele, and on the time after varicocelectomy.S. V. PichugovaI. V. RybinaYa. B. BeikinSPb RAACIarticlevaricoceleadolescentssperm antibodiesinfertilityvaricocelectomyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 22, Iss 5, Pp 969-976 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	varicocele adolescents sperm antibodies infertility varicocelectomy Immunologic diseases. Allergy RC581-607
spellingShingle	varicocele adolescents sperm antibodies infertility varicocelectomy Immunologic diseases. Allergy RC581-607 S. V. Pichugova I. V. Rybina Ya. B. Beikin Dynamics of sperm antibody levels in adolescents with left-sided varicocele
description	Varicocele means a varicose vein of the spermatic cord, being among the most common disorders diagnosed in childhood and adolescence, which suggests a high risk for infertility. Varicocele is considered an additional factor for immune-dependent infertility which results from damaged hemato-testicular barrier due to venous blood stasis, hyperthermia, testicular ischemia. Our objective was to determine levels of the sperm antibodies in serum and ejaculate in adolescents with left-sided varicocele, in order to assess the changing levels of sperm antibodies in blood serum at different ages during the postoperative period, depending on the degree of varicocele. For adolescents with left-sided varicocele and without varicocele, the serum levels of sperm antibodies were determined annually at the age of 14 to 17 years, as well as registration of sperm antibodies titer in seminal fluid at the age of 17 years. The levels of sperm antibodies in blood serum were traced in dynamics for the main group and comparison group, also comparing the groups with different degrees of varicocele, like as the patients before and after surgical varicocele correction. We did not reveal increased levels of the sperm antibodies over reference values in any subject under study. The level changes of sperm antibodies in serum showed an increase in these indexes at the age of 15-16 years in adolescents of both groups with a trend for a decrease in the comparison group by 17 years of age, however, without such tendency in the main group. No significant differences were found in the levels of sperm antibodies in blood serum depending on the degree of varicocele, and on the time after varicocelectomy.
format	article
author	S. V. Pichugova I. V. Rybina Ya. B. Beikin
author_facet	S. V. Pichugova I. V. Rybina Ya. B. Beikin
author_sort	S. V. Pichugova
title	Dynamics of sperm antibody levels in adolescents with left-sided varicocele
title_short	Dynamics of sperm antibody levels in adolescents with left-sided varicocele
title_full	Dynamics of sperm antibody levels in adolescents with left-sided varicocele
title_fullStr	Dynamics of sperm antibody levels in adolescents with left-sided varicocele
title_full_unstemmed	Dynamics of sperm antibody levels in adolescents with left-sided varicocele
title_sort	dynamics of sperm antibody levels in adolescents with left-sided varicocele
publisher	SPb RAACI
publishDate	2020
url	https://doaj.org/article/38e9ec660f944ef9913e4aff212cb279
work_keys_str_mv	AT svpichugova dynamicsofspermantibodylevelsinadolescentswithleftsidedvaricocele AT ivrybina dynamicsofspermantibodylevelsinadolescentswithleftsidedvaricocele AT yabbeikin dynamicsofspermantibodylevelsinadolescentswithleftsidedvaricocele
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Dynamics of sperm antibody levels in adolescents with left-sided varicocele

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