Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2

Target of rapamycin (TOR) kinase operates within two distinct multiprotein complexes named TORC1 and TORC2. Here the authors report a cryo-EM structure of TORC2, establish its subunit organization, providing a rationale for TORC2’s rapamycin insensitivity and the mutually exclusive inclusion of Avo3...

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Autores principales:	Manikandan Karuppasamy, Beata Kusmider, Taiana M. Oliveira, Christl Gaubitz, Manoel Prouteau, Robbie Loewith, Christiane Schaffitzel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/38eaa2c38bd64378bd64e3cfa22e3975
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spelling	oai:doaj.org-article:38eaa2c38bd64378bd64e3cfa22e39752021-12-02T14:42:24ZCryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 210.1038/s41467-017-01862-02041-1723https://doaj.org/article/38eaa2c38bd64378bd64e3cfa22e39752017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01862-0https://doaj.org/toc/2041-1723Target of rapamycin (TOR) kinase operates within two distinct multiprotein complexes named TORC1 and TORC2. Here the authors report a cryo-EM structure of TORC2, establish its subunit organization, providing a rationale for TORC2’s rapamycin insensitivity and the mutually exclusive inclusion of Avo3/Rictor or Raptor within their respective TOR complex.Manikandan KaruppasamyBeata KusmiderTaiana M. OliveiraChristl GaubitzManoel ProuteauRobbie LoewithChristiane SchaffitzelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manikandan Karuppasamy Beata Kusmider Taiana M. Oliveira Christl Gaubitz Manoel Prouteau Robbie Loewith Christiane Schaffitzel Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2
description	Target of rapamycin (TOR) kinase operates within two distinct multiprotein complexes named TORC1 and TORC2. Here the authors report a cryo-EM structure of TORC2, establish its subunit organization, providing a rationale for TORC2’s rapamycin insensitivity and the mutually exclusive inclusion of Avo3/Rictor or Raptor within their respective TOR complex.
format	article
author	Manikandan Karuppasamy Beata Kusmider Taiana M. Oliveira Christl Gaubitz Manoel Prouteau Robbie Loewith Christiane Schaffitzel
author_facet	Manikandan Karuppasamy Beata Kusmider Taiana M. Oliveira Christl Gaubitz Manoel Prouteau Robbie Loewith Christiane Schaffitzel
author_sort	Manikandan Karuppasamy
title	Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2
title_short	Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2
title_full	Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2
title_fullStr	Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2
title_full_unstemmed	Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2
title_sort	cryo-em structure of saccharomyces cerevisiae target of rapamycin complex 2
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/38eaa2c38bd64378bd64e3cfa22e3975
work_keys_str_mv	AT manikandankaruppasamy cryoemstructureofsaccharomycescerevisiaetargetofrapamycincomplex2 AT beatakusmider cryoemstructureofsaccharomycescerevisiaetargetofrapamycincomplex2 AT taianamoliveira cryoemstructureofsaccharomycescerevisiaetargetofrapamycincomplex2 AT christlgaubitz cryoemstructureofsaccharomycescerevisiaetargetofrapamycincomplex2 AT manoelprouteau cryoemstructureofsaccharomycescerevisiaetargetofrapamycincomplex2 AT robbieloewith cryoemstructureofsaccharomycescerevisiaetargetofrapamycincomplex2 AT christianeschaffitzel cryoemstructureofsaccharomycescerevisiaetargetofrapamycincomplex2
_version_	1718389682234982400

Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2

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