No association between pyrite content and lung cell responses to coal particles

Abstract There has been an increase in the identification of cases of coal workers’ pneumoconiosis (CWP) in recent years around the world. While there are a range of possible explanations for this, studies have implicated the pyrite content of coal as a key determinant of CWP risk. However, experime...

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Autores principales:	Graeme R. Zosky, Ellen J. Bennett, Macarena Pavez, B. Basil Beamish
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/38ec7d663bba47938e071f8088c813be
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spelling	oai:doaj.org-article:38ec7d663bba47938e071f8088c813be2021-12-02T14:30:52ZNo association between pyrite content and lung cell responses to coal particles10.1038/s41598-021-87517-z2045-2322https://doaj.org/article/38ec7d663bba47938e071f8088c813be2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87517-zhttps://doaj.org/toc/2045-2322Abstract There has been an increase in the identification of cases of coal workers’ pneumoconiosis (CWP) in recent years around the world. While there are a range of possible explanations for this, studies have implicated the pyrite content of coal as a key determinant of CWP risk. However, experimental studies to support this link are limited. The aim of this study was to assess the association between the pyrite content, and subsequent release of bioavailable iron, in coal particles and the response of lung cells involved in the pathogenesis of CWP (epithelial cells, macrophages and fibroblasts). Using real-world Australian coal samples, we found no evidence of an association between the pyrite content of the coal and the magnitude of the detrimental cell response. We did find evidence of an increase in IL-8 production by epithelial cells with increasing bioavailable iron (p = 0.01), however, this was not linked to the pyrite content of the coal (p = 0.75) and we did not see any evidence of a positive association in the other cell types. Given the lack of association between the pyrite content of real-world coal particles and lung cell cytotoxicity (epithelial cells and macrophages), inflammatory cytokine production (epithelial cells, macrophages and fibroblasts), and cell proliferation (fibroblasts) our data do not support the use of coal pyrite content as a predictor of CWP risk.Graeme R. ZoskyEllen J. BennettMacarena PavezB. Basil BeamishNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Graeme R. Zosky Ellen J. Bennett Macarena Pavez B. Basil Beamish No association between pyrite content and lung cell responses to coal particles
description	Abstract There has been an increase in the identification of cases of coal workers’ pneumoconiosis (CWP) in recent years around the world. While there are a range of possible explanations for this, studies have implicated the pyrite content of coal as a key determinant of CWP risk. However, experimental studies to support this link are limited. The aim of this study was to assess the association between the pyrite content, and subsequent release of bioavailable iron, in coal particles and the response of lung cells involved in the pathogenesis of CWP (epithelial cells, macrophages and fibroblasts). Using real-world Australian coal samples, we found no evidence of an association between the pyrite content of the coal and the magnitude of the detrimental cell response. We did find evidence of an increase in IL-8 production by epithelial cells with increasing bioavailable iron (p = 0.01), however, this was not linked to the pyrite content of the coal (p = 0.75) and we did not see any evidence of a positive association in the other cell types. Given the lack of association between the pyrite content of real-world coal particles and lung cell cytotoxicity (epithelial cells and macrophages), inflammatory cytokine production (epithelial cells, macrophages and fibroblasts), and cell proliferation (fibroblasts) our data do not support the use of coal pyrite content as a predictor of CWP risk.
format	article
author	Graeme R. Zosky Ellen J. Bennett Macarena Pavez B. Basil Beamish
author_facet	Graeme R. Zosky Ellen J. Bennett Macarena Pavez B. Basil Beamish
author_sort	Graeme R. Zosky
title	No association between pyrite content and lung cell responses to coal particles
title_short	No association between pyrite content and lung cell responses to coal particles
title_full	No association between pyrite content and lung cell responses to coal particles
title_fullStr	No association between pyrite content and lung cell responses to coal particles
title_full_unstemmed	No association between pyrite content and lung cell responses to coal particles
title_sort	no association between pyrite content and lung cell responses to coal particles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/38ec7d663bba47938e071f8088c813be
work_keys_str_mv	AT graemerzosky noassociationbetweenpyritecontentandlungcellresponsestocoalparticles AT ellenjbennett noassociationbetweenpyritecontentandlungcellresponsestocoalparticles AT macarenapavez noassociationbetweenpyritecontentandlungcellresponsestocoalparticles AT bbasilbeamish noassociationbetweenpyritecontentandlungcellresponsestocoalparticles
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No association between pyrite content and lung cell responses to coal particles

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