Colistin-resistant Gram-negative bacteria in Saudi Arabia: A literature review

Gram-negative bacteria (GNB) represent a major source of morbidity worldwide. The antimicrobial resistance of GNB has recently increased worldwide, that led to using colistin to treat multidrug resistant (MDR) GNB infections. Annually, Saudi Arabia hosts mass religious occasions, where the risk of i...

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Autor principal:	Abdulaziz Alqasim
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Antimicrobial resistance Colistin Gram-negative bacteria Escherichia coli Acinetobacter baumannii Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/38ede8a6987b491db56cdb8c7423693c
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spelling	oai:doaj.org-article:38ede8a6987b491db56cdb8c7423693c2021-11-18T04:44:04ZColistin-resistant Gram-negative bacteria in Saudi Arabia: A literature review1018-364710.1016/j.jksus.2021.101610https://doaj.org/article/38ede8a6987b491db56cdb8c7423693c2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S101836472100272Xhttps://doaj.org/toc/1018-3647Gram-negative bacteria (GNB) represent a major source of morbidity worldwide. The antimicrobial resistance of GNB has recently increased worldwide, that led to using colistin to treat multidrug resistant (MDR) GNB infections. Annually, Saudi Arabia hosts mass religious occasions, where the risk of infectious disease transmission is very high. This review aimed to provide an update on the current prevalence and molecular epidemiology of colistin-resistant GNB locally. It also assessed the role of mass gatherings in triggering colistin resistance. Although colistin is still highly effective against GNB isolates locally, high colistin resistance has been identified among major GNB such as Acinetobacter baumannii and Klebsiella pneumoniae. Colistin resistance among certain MDR Escherichia coli clones, such as ST131, has recently emerged and this is alarming given the rapid global dissemination of this clone. Local data has shown the role of mass religious gatherings in triggering the acquisition of colistin resistance, which makes the screening of colistin resistance determinants very important to limit the spread of colistin resistant GNB between pilgrims.Abdulaziz AlqasimElsevierarticleAntimicrobial resistanceColistinGram-negative bacteriaEscherichia coliAcinetobacter baumanniiScience (General)Q1-390ENJournal of King Saud University: Science, Vol 33, Iss 8, Pp 101610- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antimicrobial resistance Colistin Gram-negative bacteria Escherichia coli Acinetobacter baumannii Science (General) Q1-390
spellingShingle	Antimicrobial resistance Colistin Gram-negative bacteria Escherichia coli Acinetobacter baumannii Science (General) Q1-390 Abdulaziz Alqasim Colistin-resistant Gram-negative bacteria in Saudi Arabia: A literature review
description	Gram-negative bacteria (GNB) represent a major source of morbidity worldwide. The antimicrobial resistance of GNB has recently increased worldwide, that led to using colistin to treat multidrug resistant (MDR) GNB infections. Annually, Saudi Arabia hosts mass religious occasions, where the risk of infectious disease transmission is very high. This review aimed to provide an update on the current prevalence and molecular epidemiology of colistin-resistant GNB locally. It also assessed the role of mass gatherings in triggering colistin resistance. Although colistin is still highly effective against GNB isolates locally, high colistin resistance has been identified among major GNB such as Acinetobacter baumannii and Klebsiella pneumoniae. Colistin resistance among certain MDR Escherichia coli clones, such as ST131, has recently emerged and this is alarming given the rapid global dissemination of this clone. Local data has shown the role of mass religious gatherings in triggering the acquisition of colistin resistance, which makes the screening of colistin resistance determinants very important to limit the spread of colistin resistant GNB between pilgrims.
format	article
author	Abdulaziz Alqasim
author_facet	Abdulaziz Alqasim
author_sort	Abdulaziz Alqasim
title	Colistin-resistant Gram-negative bacteria in Saudi Arabia: A literature review
title_short	Colistin-resistant Gram-negative bacteria in Saudi Arabia: A literature review
title_full	Colistin-resistant Gram-negative bacteria in Saudi Arabia: A literature review
title_fullStr	Colistin-resistant Gram-negative bacteria in Saudi Arabia: A literature review
title_full_unstemmed	Colistin-resistant Gram-negative bacteria in Saudi Arabia: A literature review
title_sort	colistin-resistant gram-negative bacteria in saudi arabia: a literature review
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/38ede8a6987b491db56cdb8c7423693c
work_keys_str_mv	AT abdulazizalqasim colistinresistantgramnegativebacteriainsaudiarabiaaliteraturereview
_version_	1718425091643015168

Colistin-resistant Gram-negative bacteria in Saudi Arabia: A literature review

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