Evaluation of Pretreatment Magnetic Resonance Elastography for the Prediction of Radiation-Induced Liver Disease

Purpose: Magnetic resonance (MR) elastography (E) is a noninvasive technique for quantifying liver stiffness (LS) for fibrosis. This study evaluates whether LS is associated with risk of developing radiation-induced liver disease (RILD) in patients receiving liver-directed radiation therapy (RT). Me...

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Autores principales:	Trey C. Mullikin, MD, Kay M. Pepin, PhD, Jaden E. Evans, MD, Sudhakar K. Venkatesh, MD, Richard L. Ehman, MD, Kenneth W. Merrell, MD, Michael G. Haddock, MD, William S. Harmsen, MS, Michael G. Herman, PhD, Christopher L. Hallemeier, MD
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/38f84dbf49864b5caaac3bd31a74fbcc
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spelling	oai:doaj.org-article:38f84dbf49864b5caaac3bd31a74fbcc2021-11-12T04:43:16ZEvaluation of Pretreatment Magnetic Resonance Elastography for the Prediction of Radiation-Induced Liver Disease2452-109410.1016/j.adro.2021.100793https://doaj.org/article/38f84dbf49864b5caaac3bd31a74fbcc2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452109421001512https://doaj.org/toc/2452-1094Purpose: Magnetic resonance (MR) elastography (E) is a noninvasive technique for quantifying liver stiffness (LS) for fibrosis. This study evaluates whether LS is associated with risk of developing radiation-induced liver disease (RILD) in patients receiving liver-directed radiation therapy (RT). Methods and Materials: Based on prior studies, LS ≤3 kPa was considered normal and LS >3.0 kPa as representing fibrosis. RILD was defined as an increase in Child-Pugh (CP) score of ≥2 from baseline within 1 year of RT. Univariate and multivariate Cox models were used to assess correlation. Results: One hundred two patients, 51 with primary liver tumors and 51 with liver metastases, were identified with sufficient follow-up. In univariate models, pre-RT LS >3.0 kPa (hazard ratio [HR] 4.9; 95% confidence interval [CI], 1.6-14; P = .004), body mass index (BMI), clinical cirrhosis, CP score, albumin-bilirubin (ALBI) grade 2, primary liver tumor, and mean liver dose were significantly associated with risk of post-RT RILD. In a multivariate analysis, LS >3.0 and mean liver dose both were significantly associated with RILD risk. Conclusions: Elevated pre-RT LS is associated with an increased risk of RILD in patients receiving liver-directed RT.Trey C. Mullikin, MDKay M. Pepin, PhDJaden E. Evans, MDSudhakar K. Venkatesh, MDRichard L. Ehman, MDKenneth W. Merrell, MDMichael G. Haddock, MDWilliam S. Harmsen, MSMichael G. Herman, PhDChristopher L. Hallemeier, MDElsevierarticleMedical physics. Medical radiology. Nuclear medicineR895-920Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENAdvances in Radiation Oncology, Vol 6, Iss 6, Pp 100793- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Trey C. Mullikin, MD Kay M. Pepin, PhD Jaden E. Evans, MD Sudhakar K. Venkatesh, MD Richard L. Ehman, MD Kenneth W. Merrell, MD Michael G. Haddock, MD William S. Harmsen, MS Michael G. Herman, PhD Christopher L. Hallemeier, MD Evaluation of Pretreatment Magnetic Resonance Elastography for the Prediction of Radiation-Induced Liver Disease
description	Purpose: Magnetic resonance (MR) elastography (E) is a noninvasive technique for quantifying liver stiffness (LS) for fibrosis. This study evaluates whether LS is associated with risk of developing radiation-induced liver disease (RILD) in patients receiving liver-directed radiation therapy (RT). Methods and Materials: Based on prior studies, LS ≤3 kPa was considered normal and LS >3.0 kPa as representing fibrosis. RILD was defined as an increase in Child-Pugh (CP) score of ≥2 from baseline within 1 year of RT. Univariate and multivariate Cox models were used to assess correlation. Results: One hundred two patients, 51 with primary liver tumors and 51 with liver metastases, were identified with sufficient follow-up. In univariate models, pre-RT LS >3.0 kPa (hazard ratio [HR] 4.9; 95% confidence interval [CI], 1.6-14; P = .004), body mass index (BMI), clinical cirrhosis, CP score, albumin-bilirubin (ALBI) grade 2, primary liver tumor, and mean liver dose were significantly associated with risk of post-RT RILD. In a multivariate analysis, LS >3.0 and mean liver dose both were significantly associated with RILD risk. Conclusions: Elevated pre-RT LS is associated with an increased risk of RILD in patients receiving liver-directed RT.
format	article
author	Trey C. Mullikin, MD Kay M. Pepin, PhD Jaden E. Evans, MD Sudhakar K. Venkatesh, MD Richard L. Ehman, MD Kenneth W. Merrell, MD Michael G. Haddock, MD William S. Harmsen, MS Michael G. Herman, PhD Christopher L. Hallemeier, MD
author_facet	Trey C. Mullikin, MD Kay M. Pepin, PhD Jaden E. Evans, MD Sudhakar K. Venkatesh, MD Richard L. Ehman, MD Kenneth W. Merrell, MD Michael G. Haddock, MD William S. Harmsen, MS Michael G. Herman, PhD Christopher L. Hallemeier, MD
author_sort	Trey C. Mullikin, MD
title	Evaluation of Pretreatment Magnetic Resonance Elastography for the Prediction of Radiation-Induced Liver Disease
title_short	Evaluation of Pretreatment Magnetic Resonance Elastography for the Prediction of Radiation-Induced Liver Disease
title_full	Evaluation of Pretreatment Magnetic Resonance Elastography for the Prediction of Radiation-Induced Liver Disease
title_fullStr	Evaluation of Pretreatment Magnetic Resonance Elastography for the Prediction of Radiation-Induced Liver Disease
title_full_unstemmed	Evaluation of Pretreatment Magnetic Resonance Elastography for the Prediction of Radiation-Induced Liver Disease
title_sort	evaluation of pretreatment magnetic resonance elastography for the prediction of radiation-induced liver disease
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/38f84dbf49864b5caaac3bd31a74fbcc
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Evaluation of Pretreatment Magnetic Resonance Elastography for the Prediction of Radiation-Induced Liver Disease

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