HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells

HIV insertions in hematopoietic cells are enriched in BACH2 or MLK2 genes, but the selective advantages conferred are unknown. Here, the authors show that BACH2 and additionally STAT5B are activated by viral insertions, generating chimeric mRNAs specifically enriched in T regulatory cells favoring t...

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Autores principales:	Daniela Cesana, Francesca R. Santoni de Sio, Laura Rudilosso, Pierangela Gallina, Andrea Calabria, Stefano Beretta, Ivan Merelli, Elena Bruzzesi, Laura Passerini, Silvia Nozza, Elisa Vicenzi, Guido Poli, Silvia Gregori, Giuseppe Tambussi, Eugenio Montini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/38fde9b4a8ce4bf48831faf183af13eb
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spelling	oai:doaj.org-article:38fde9b4a8ce4bf48831faf183af13eb2021-12-02T14:40:49ZHIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells10.1038/s41467-017-00609-12041-1723https://doaj.org/article/38fde9b4a8ce4bf48831faf183af13eb2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00609-1https://doaj.org/toc/2041-1723HIV insertions in hematopoietic cells are enriched in BACH2 or MLK2 genes, but the selective advantages conferred are unknown. Here, the authors show that BACH2 and additionally STAT5B are activated by viral insertions, generating chimeric mRNAs specifically enriched in T regulatory cells favoring their persistence.Daniela CesanaFrancesca R. Santoni de SioLaura RudilossoPierangela GallinaAndrea CalabriaStefano BerettaIvan MerelliElena BruzzesiLaura PasseriniSilvia NozzaElisa VicenziGuido PoliSilvia GregoriGiuseppe TambussiEugenio MontiniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniela Cesana Francesca R. Santoni de Sio Laura Rudilosso Pierangela Gallina Andrea Calabria Stefano Beretta Ivan Merelli Elena Bruzzesi Laura Passerini Silvia Nozza Elisa Vicenzi Guido Poli Silvia Gregori Giuseppe Tambussi Eugenio Montini HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells
description	HIV insertions in hematopoietic cells are enriched in BACH2 or MLK2 genes, but the selective advantages conferred are unknown. Here, the authors show that BACH2 and additionally STAT5B are activated by viral insertions, generating chimeric mRNAs specifically enriched in T regulatory cells favoring their persistence.
format	article
author	Daniela Cesana Francesca R. Santoni de Sio Laura Rudilosso Pierangela Gallina Andrea Calabria Stefano Beretta Ivan Merelli Elena Bruzzesi Laura Passerini Silvia Nozza Elisa Vicenzi Guido Poli Silvia Gregori Giuseppe Tambussi Eugenio Montini
author_facet	Daniela Cesana Francesca R. Santoni de Sio Laura Rudilosso Pierangela Gallina Andrea Calabria Stefano Beretta Ivan Merelli Elena Bruzzesi Laura Passerini Silvia Nozza Elisa Vicenzi Guido Poli Silvia Gregori Giuseppe Tambussi Eugenio Montini
author_sort	Daniela Cesana
title	HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells
title_short	HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells
title_full	HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells
title_fullStr	HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells
title_full_unstemmed	HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells
title_sort	hiv-1-mediated insertional activation of stat5b and bach2 trigger viral reservoir in t regulatory cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/38fde9b4a8ce4bf48831faf183af13eb
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HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells

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