The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

In cancer the side effects of therapeutic agents can provoke senescence-associated secretory phenotype (SASP), which can drive cancer resistance. During the DNA damage response, transcription factor Zscan4 expression is elevated by an ATM-TRAF6-TAK1 axis leading to long term SASP in human stromal ce...

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Autores principales: Boyi Zhang, Da Fu, Qixia Xu, Xianling Cong, Chunyan Wu, Xiaoming Zhong, Yushui Ma, Zhongwei Lv, Fei Chen, Liu Han, Min Qian, Y. Eugene Chin, Eric W. -F. Lam, Paul Chiao, Yu Sun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/38fe8f7806684fd2a11d5418e60e0cf1
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spelling oai:doaj.org-article:38fe8f7806684fd2a11d5418e60e0cf12021-12-02T15:33:38ZThe senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK110.1038/s41467-018-04010-42041-1723https://doaj.org/article/38fe8f7806684fd2a11d5418e60e0cf12018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04010-4https://doaj.org/toc/2041-1723In cancer the side effects of therapeutic agents can provoke senescence-associated secretory phenotype (SASP), which can drive cancer resistance. During the DNA damage response, transcription factor Zscan4 expression is elevated by an ATM-TRAF6-TAK1 axis leading to long term SASP in human stromal cells.Boyi ZhangDa FuQixia XuXianling CongChunyan WuXiaoming ZhongYushui MaZhongwei LvFei ChenLiu HanMin QianY. Eugene ChinEric W. -F. LamPaul ChiaoYu SunNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Boyi Zhang
Da Fu
Qixia Xu
Xianling Cong
Chunyan Wu
Xiaoming Zhong
Yushui Ma
Zhongwei Lv
Fei Chen
Liu Han
Min Qian
Y. Eugene Chin
Eric W. -F. Lam
Paul Chiao
Yu Sun
The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1
description In cancer the side effects of therapeutic agents can provoke senescence-associated secretory phenotype (SASP), which can drive cancer resistance. During the DNA damage response, transcription factor Zscan4 expression is elevated by an ATM-TRAF6-TAK1 axis leading to long term SASP in human stromal cells.
format article
author Boyi Zhang
Da Fu
Qixia Xu
Xianling Cong
Chunyan Wu
Xiaoming Zhong
Yushui Ma
Zhongwei Lv
Fei Chen
Liu Han
Min Qian
Y. Eugene Chin
Eric W. -F. Lam
Paul Chiao
Yu Sun
author_facet Boyi Zhang
Da Fu
Qixia Xu
Xianling Cong
Chunyan Wu
Xiaoming Zhong
Yushui Ma
Zhongwei Lv
Fei Chen
Liu Han
Min Qian
Y. Eugene Chin
Eric W. -F. Lam
Paul Chiao
Yu Sun
author_sort Boyi Zhang
title The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1
title_short The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1
title_full The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1
title_fullStr The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1
title_full_unstemmed The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1
title_sort senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving zscan4 and tak1
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/38fe8f7806684fd2a11d5418e60e0cf1
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