Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis

MiRNAs are small RNA molecules that can regulate gene expression. Here the authors show that expression of several exosomal miRNAs are altered in patients with multiple sclerosis, and that let-7i modulates regulatory T cell homeostasis to contribute to pathogenesis.

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Autores principales:	Kimitoshi Kimura, Hirohiko Hohjoh, Masashi Fukuoka, Wakiro Sato, Shinji Oki, Chiharu Tomi, Hiromi Yamaguchi, Takayuki Kondo, Ryosuke Takahashi, Takashi Yamamura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39030d68cecb4083837a09a44d6cae96
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spelling	oai:doaj.org-article:39030d68cecb4083837a09a44d6cae962021-12-02T17:31:28ZCirculating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis10.1038/s41467-017-02406-22041-1723https://doaj.org/article/39030d68cecb4083837a09a44d6cae962018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02406-2https://doaj.org/toc/2041-1723MiRNAs are small RNA molecules that can regulate gene expression. Here the authors show that expression of several exosomal miRNAs are altered in patients with multiple sclerosis, and that let-7i modulates regulatory T cell homeostasis to contribute to pathogenesis.Kimitoshi KimuraHirohiko HohjohMasashi FukuokaWakiro SatoShinji OkiChiharu TomiHiromi YamaguchiTakayuki KondoRyosuke TakahashiTakashi YamamuraNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kimitoshi Kimura Hirohiko Hohjoh Masashi Fukuoka Wakiro Sato Shinji Oki Chiharu Tomi Hiromi Yamaguchi Takayuki Kondo Ryosuke Takahashi Takashi Yamamura Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
description	MiRNAs are small RNA molecules that can regulate gene expression. Here the authors show that expression of several exosomal miRNAs are altered in patients with multiple sclerosis, and that let-7i modulates regulatory T cell homeostasis to contribute to pathogenesis.
format	article
author	Kimitoshi Kimura Hirohiko Hohjoh Masashi Fukuoka Wakiro Sato Shinji Oki Chiharu Tomi Hiromi Yamaguchi Takayuki Kondo Ryosuke Takahashi Takashi Yamamura
author_facet	Kimitoshi Kimura Hirohiko Hohjoh Masashi Fukuoka Wakiro Sato Shinji Oki Chiharu Tomi Hiromi Yamaguchi Takayuki Kondo Ryosuke Takahashi Takashi Yamamura
author_sort	Kimitoshi Kimura
title	Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
title_short	Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
title_full	Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
title_fullStr	Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
title_full_unstemmed	Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
title_sort	circulating exosomes suppress the induction of regulatory t cells via let-7i in multiple sclerosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/39030d68cecb4083837a09a44d6cae96
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Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis

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