MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation

MKL1 is a key transcriptional co-activator of actin cytoskeleton genes. Here the authors show that MKL1 activation in somatic cells reduces chromatin accessibility and hinders full reprogramming to pluripotency. Reduction of MKL1, disruption of actin cytoskeleton and its links to the nucleus relieve...

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Autores principales:	Xiao Hu, Zongzhi Z. Liu, Xinyue Chen, Vincent P. Schulz, Abhishek Kumar, Amaleah A. Hartman, Jason Weinstein, Jessica F. Johnston, Elisa C. Rodriguez, Anna E. Eastman, Jijun Cheng, Liz Min, Mei Zhong, Christopher Carroll, Patrick G. Gallagher, Jun Lu, Martin Schwartz, Megan C. King, Diane S. Krause, Shangqin Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39034a1a1b414222967219825619062a
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spelling	oai:doaj.org-article:39034a1a1b414222967219825619062a2021-12-02T17:01:50ZMKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation10.1038/s41467-019-09636-62041-1723https://doaj.org/article/39034a1a1b414222967219825619062a2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09636-6https://doaj.org/toc/2041-1723MKL1 is a key transcriptional co-activator of actin cytoskeleton genes. Here the authors show that MKL1 activation in somatic cells reduces chromatin accessibility and hinders full reprogramming to pluripotency. Reduction of MKL1, disruption of actin cytoskeleton and its links to the nucleus relieve this repression.Xiao HuZongzhi Z. LiuXinyue ChenVincent P. SchulzAbhishek KumarAmaleah A. HartmanJason WeinsteinJessica F. JohnstonElisa C. RodriguezAnna E. EastmanJijun ChengLiz MinMei ZhongChristopher CarrollPatrick G. GallagherJun LuMartin SchwartzMegan C. KingDiane S. KrauseShangqin GuoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiao Hu Zongzhi Z. Liu Xinyue Chen Vincent P. Schulz Abhishek Kumar Amaleah A. Hartman Jason Weinstein Jessica F. Johnston Elisa C. Rodriguez Anna E. Eastman Jijun Cheng Liz Min Mei Zhong Christopher Carroll Patrick G. Gallagher Jun Lu Martin Schwartz Megan C. King Diane S. Krause Shangqin Guo MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation
description	MKL1 is a key transcriptional co-activator of actin cytoskeleton genes. Here the authors show that MKL1 activation in somatic cells reduces chromatin accessibility and hinders full reprogramming to pluripotency. Reduction of MKL1, disruption of actin cytoskeleton and its links to the nucleus relieve this repression.
format	article
author	Xiao Hu Zongzhi Z. Liu Xinyue Chen Vincent P. Schulz Abhishek Kumar Amaleah A. Hartman Jason Weinstein Jessica F. Johnston Elisa C. Rodriguez Anna E. Eastman Jijun Cheng Liz Min Mei Zhong Christopher Carroll Patrick G. Gallagher Jun Lu Martin Schwartz Megan C. King Diane S. Krause Shangqin Guo
author_facet	Xiao Hu Zongzhi Z. Liu Xinyue Chen Vincent P. Schulz Abhishek Kumar Amaleah A. Hartman Jason Weinstein Jessica F. Johnston Elisa C. Rodriguez Anna E. Eastman Jijun Cheng Liz Min Mei Zhong Christopher Carroll Patrick G. Gallagher Jun Lu Martin Schwartz Megan C. King Diane S. Krause Shangqin Guo
author_sort	Xiao Hu
title	MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation
title_short	MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation
title_full	MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation
title_fullStr	MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation
title_full_unstemmed	MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation
title_sort	mkl1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/39034a1a1b414222967219825619062a
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MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation

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