Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response

Integrins are key modulators of cell adhesion and signaling. Here the authors show, unexpectedly, that a complex of integrins and the lipid 25-hydroxycholesterol induces FAK activation and proinflammatory cytokine production, thereby serving as an integral part of innate immunity regulation.

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Detalles Bibliográficos
Autores principales: Swechha M. Pokharel, Niraj K. Shil, Jeevan B. GC, Zachary T. Colburn, Su-Yu Tsai, Jesus A. Segovia, Te-Hung Chang, Smarajit Bandyopadhyay, Senthil Natesan, Jonathan C. R. Jones, Santanu Bose
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/39041573d0274347a3d21da9222a9805
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Descripción
Sumario:Integrins are key modulators of cell adhesion and signaling. Here the authors show, unexpectedly, that a complex of integrins and the lipid 25-hydroxycholesterol induces FAK activation and proinflammatory cytokine production, thereby serving as an integral part of innate immunity regulation.