Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response

Integrins are key modulators of cell adhesion and signaling. Here the authors show, unexpectedly, that a complex of integrins and the lipid 25-hydroxycholesterol induces FAK activation and proinflammatory cytokine production, thereby serving as an integral part of innate immunity regulation.

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Autores principales:	Swechha M. Pokharel, Niraj K. Shil, Jeevan B. GC, Zachary T. Colburn, Su-Yu Tsai, Jesus A. Segovia, Te-Hung Chang, Smarajit Bandyopadhyay, Senthil Natesan, Jonathan C. R. Jones, Santanu Bose
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39041573d0274347a3d21da9222a9805
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spelling	oai:doaj.org-article:39041573d0274347a3d21da9222a98052021-12-02T14:38:44ZIntegrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response10.1038/s41467-019-09453-x2041-1723https://doaj.org/article/39041573d0274347a3d21da9222a98052019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09453-xhttps://doaj.org/toc/2041-1723Integrins are key modulators of cell adhesion and signaling. Here the authors show, unexpectedly, that a complex of integrins and the lipid 25-hydroxycholesterol induces FAK activation and proinflammatory cytokine production, thereby serving as an integral part of innate immunity regulation.Swechha M. PokharelNiraj K. ShilJeevan B. GCZachary T. ColburnSu-Yu TsaiJesus A. SegoviaTe-Hung ChangSmarajit BandyopadhyaySenthil NatesanJonathan C. R. JonesSantanu BoseNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Swechha M. Pokharel Niraj K. Shil Jeevan B. GC Zachary T. Colburn Su-Yu Tsai Jesus A. Segovia Te-Hung Chang Smarajit Bandyopadhyay Senthil Natesan Jonathan C. R. Jones Santanu Bose Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response
description	Integrins are key modulators of cell adhesion and signaling. Here the authors show, unexpectedly, that a complex of integrins and the lipid 25-hydroxycholesterol induces FAK activation and proinflammatory cytokine production, thereby serving as an integral part of innate immunity regulation.
format	article
author	Swechha M. Pokharel Niraj K. Shil Jeevan B. GC Zachary T. Colburn Su-Yu Tsai Jesus A. Segovia Te-Hung Chang Smarajit Bandyopadhyay Senthil Natesan Jonathan C. R. Jones Santanu Bose
author_facet	Swechha M. Pokharel Niraj K. Shil Jeevan B. GC Zachary T. Colburn Su-Yu Tsai Jesus A. Segovia Te-Hung Chang Smarajit Bandyopadhyay Senthil Natesan Jonathan C. R. Jones Santanu Bose
author_sort	Swechha M. Pokharel
title	Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response
title_short	Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response
title_full	Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response
title_fullStr	Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response
title_full_unstemmed	Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response
title_sort	integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/39041573d0274347a3d21da9222a9805
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Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response

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