Diagnostic Accuracy of Ultrasound Scanning for Prenatal Microcephaly in the context of Zika Virus Infection: A Systematic Review and Meta-analysis

Abstract To assess the accuracy of ultrasound measurements of fetal biometric parameters for prenatal diagnosis of microcephaly in the context of Zika virus (ZIKV) infection, we searched bibliographic databases for studies published until March 3rd, 2016. We extracted the numbers of true positives,...

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Autores principales:	Ezinne C. Chibueze, Alex J. Q. Parsons, Katharina da Silva Lopes, Takemoto Yo, Toshiyuki Swa, Chie Nagata, Nobuyuki Horita, Naho Morisaki, Olukunmi O. Balogun, Amarjargal Dagvadorj, Erika Ota, Rintaro Mori, Olufemi T. Oladapo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3905a9a0546b433e8268b87e40f5feb4
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spelling	oai:doaj.org-article:3905a9a0546b433e8268b87e40f5feb42021-12-02T16:06:09ZDiagnostic Accuracy of Ultrasound Scanning for Prenatal Microcephaly in the context of Zika Virus Infection: A Systematic Review and Meta-analysis10.1038/s41598-017-01991-y2045-2322https://doaj.org/article/3905a9a0546b433e8268b87e40f5feb42017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01991-yhttps://doaj.org/toc/2045-2322Abstract To assess the accuracy of ultrasound measurements of fetal biometric parameters for prenatal diagnosis of microcephaly in the context of Zika virus (ZIKV) infection, we searched bibliographic databases for studies published until March 3rd, 2016. We extracted the numbers of true positives, false positives, true negatives, and false negatives and performed a meta-analysis to estimate group sensitivity and specificity. Predictive values for ZIKV-infected pregnancies were extrapolated from those obtained for pregnancies unrelated to ZIKV. Of 111 eligible full texts, nine studies met our inclusion criteria. Pooled estimates from two studies showed that at 3, 4 and 5 standard deviations (SDs) <mean, sensitivities were 84%, 68% and 58% for head circumference (HC); 76%, 58% and 58% for occipitofrontal diameter (OFD); and 94%, 85% and 59% for biparietal diameter (BPD). Specificities at 3, 4 and 5 SDs below the mean were 70%, 91% and 97% for HC; 84%, 97% and 97% for OFD; and 16%, 46% and 80% for BPD. No study including ZIKV-infected pregnant women was identified. OFD and HC were more consistent in specificity and sensitivity at lower thresholds compared to higher thresholds. Therefore, prenatal ultrasound appears more accurate in detecting the absence of microcephaly than its presence.Ezinne C. ChibuezeAlex J. Q. ParsonsKatharina da Silva LopesTakemoto YoToshiyuki SwaChie NagataNobuyuki HoritaNaho MorisakiOlukunmi O. BalogunAmarjargal DagvadorjErika OtaRintaro MoriOlufemi T. OladapoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ezinne C. Chibueze Alex J. Q. Parsons Katharina da Silva Lopes Takemoto Yo Toshiyuki Swa Chie Nagata Nobuyuki Horita Naho Morisaki Olukunmi O. Balogun Amarjargal Dagvadorj Erika Ota Rintaro Mori Olufemi T. Oladapo Diagnostic Accuracy of Ultrasound Scanning for Prenatal Microcephaly in the context of Zika Virus Infection: A Systematic Review and Meta-analysis
description	Abstract To assess the accuracy of ultrasound measurements of fetal biometric parameters for prenatal diagnosis of microcephaly in the context of Zika virus (ZIKV) infection, we searched bibliographic databases for studies published until March 3rd, 2016. We extracted the numbers of true positives, false positives, true negatives, and false negatives and performed a meta-analysis to estimate group sensitivity and specificity. Predictive values for ZIKV-infected pregnancies were extrapolated from those obtained for pregnancies unrelated to ZIKV. Of 111 eligible full texts, nine studies met our inclusion criteria. Pooled estimates from two studies showed that at 3, 4 and 5 standard deviations (SDs) <mean, sensitivities were 84%, 68% and 58% for head circumference (HC); 76%, 58% and 58% for occipitofrontal diameter (OFD); and 94%, 85% and 59% for biparietal diameter (BPD). Specificities at 3, 4 and 5 SDs below the mean were 70%, 91% and 97% for HC; 84%, 97% and 97% for OFD; and 16%, 46% and 80% for BPD. No study including ZIKV-infected pregnant women was identified. OFD and HC were more consistent in specificity and sensitivity at lower thresholds compared to higher thresholds. Therefore, prenatal ultrasound appears more accurate in detecting the absence of microcephaly than its presence.
format	article
author	Ezinne C. Chibueze Alex J. Q. Parsons Katharina da Silva Lopes Takemoto Yo Toshiyuki Swa Chie Nagata Nobuyuki Horita Naho Morisaki Olukunmi O. Balogun Amarjargal Dagvadorj Erika Ota Rintaro Mori Olufemi T. Oladapo
author_facet	Ezinne C. Chibueze Alex J. Q. Parsons Katharina da Silva Lopes Takemoto Yo Toshiyuki Swa Chie Nagata Nobuyuki Horita Naho Morisaki Olukunmi O. Balogun Amarjargal Dagvadorj Erika Ota Rintaro Mori Olufemi T. Oladapo
author_sort	Ezinne C. Chibueze
title	Diagnostic Accuracy of Ultrasound Scanning for Prenatal Microcephaly in the context of Zika Virus Infection: A Systematic Review and Meta-analysis
title_short	Diagnostic Accuracy of Ultrasound Scanning for Prenatal Microcephaly in the context of Zika Virus Infection: A Systematic Review and Meta-analysis
title_full	Diagnostic Accuracy of Ultrasound Scanning for Prenatal Microcephaly in the context of Zika Virus Infection: A Systematic Review and Meta-analysis
title_fullStr	Diagnostic Accuracy of Ultrasound Scanning for Prenatal Microcephaly in the context of Zika Virus Infection: A Systematic Review and Meta-analysis
title_full_unstemmed	Diagnostic Accuracy of Ultrasound Scanning for Prenatal Microcephaly in the context of Zika Virus Infection: A Systematic Review and Meta-analysis
title_sort	diagnostic accuracy of ultrasound scanning for prenatal microcephaly in the context of zika virus infection: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3905a9a0546b433e8268b87e40f5feb4
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Diagnostic Accuracy of Ultrasound Scanning for Prenatal Microcephaly in the context of Zika Virus Infection: A Systematic Review and Meta-analysis

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