Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo

Songping Zheng,1,* Xiang Gao,1,2,* Xiaoxiao Liu,1 Ting Yu,1 Tianying Zheng,1 Yi Wang,1 Chao You1 1Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, People’s Republic of China; 2Department of Pharmacology, Yale School of Medicine, Yale...

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Autores principales:	Zheng S, Gao X, Liu X, Yu T, Zheng T, Wang Y, You C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	curcumin glioma cell apoptosis cell proliferation angiogenesis. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3905e4fbe8bd472ea9f2eb493399ec47
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spelling	oai:doaj.org-article:3905e4fbe8bd472ea9f2eb493399ec472021-12-02T03:54:13ZBiodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo1178-2013https://doaj.org/article/3905e4fbe8bd472ea9f2eb493399ec472016-06-01T00:00:00Zhttps://www.dovepress.com/biodegradable-micelles-enhance-the-antiglioma-activity-of-curcumin-in--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Songping Zheng,1,* Xiang Gao,1,2,* Xiaoxiao Liu,1 Ting Yu,1 Tianying Zheng,1 Yi Wang,1 Chao You1 1Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, People’s Republic of China; 2Department of Pharmacology, Yale School of Medicine, Yale University, New Haven, CT, USA *These authors contributed equally to this work Abstract: Curcumin (Cur), a natural polyphenol of Curcuma longa, has been recently reported to possess antitumor activities. However, due to its poor aqueous solubility and low biological availability, the clinical application of Cur is quite limited. The encapsulation of hydrophobic drugs into nanoparticles is an effective way to improve their pharmaceutical activities. In this research, nanomicelles loaded with Cur were formulated by a self-assembly method with biodegradable monomethoxy poly(ethylene glycol)-poly(lactide) copolymers (MPEG-PLAs). After encapsulation, the cellular uptake was increased and Cur could be released from MPEG-PLA micelles in a sustained manner. The Cur-loaded MPEG-PLA micelles (Cur/MPEG-PLA micelles) exhibited an enhanced toxicity on C6 and U251 glioma cells and induced more apoptosis on C6 glioma cells compared with free Cur. Moreover, the therapy efficiency of Cur/MPEG-PLA micelles was evaluated at length on a nude mouse model bearing glioma. The Cur/MPEG-PLA micelles were more effective on suppressing tumor growth compared with free Cur, which indicated that Cur/MPEG-PLA micelles improved the antiglioma activity of Cur in vivo. The results of immunohistochemical and immunofluorescent analysis indicated that the induction of apoptosis, antiangiogenesis, and inhibition of cell proliferation may contribute to the improvement in antiglioma effects. Our data suggested that Cur/MPEG-PLA may have potential clinic applications in glioma therapy. Keywords: curcumin, glioma, cell apoptosis, cell proliferation, angiogenesis Zheng SGao XLiu XYu TZheng TWang YYou CDove Medical Pressarticlecurcumingliomacell apoptosiscell proliferationangiogenesis.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2721-2736 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	curcumin glioma cell apoptosis cell proliferation angiogenesis. Medicine (General) R5-920
spellingShingle	curcumin glioma cell apoptosis cell proliferation angiogenesis. Medicine (General) R5-920 Zheng S Gao X Liu X Yu T Zheng T Wang Y You C Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo
description	Songping Zheng,1,* Xiang Gao,1,2,* Xiaoxiao Liu,1 Ting Yu,1 Tianying Zheng,1 Yi Wang,1 Chao You1 1Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, People’s Republic of China; 2Department of Pharmacology, Yale School of Medicine, Yale University, New Haven, CT, USA *These authors contributed equally to this work Abstract: Curcumin (Cur), a natural polyphenol of Curcuma longa, has been recently reported to possess antitumor activities. However, due to its poor aqueous solubility and low biological availability, the clinical application of Cur is quite limited. The encapsulation of hydrophobic drugs into nanoparticles is an effective way to improve their pharmaceutical activities. In this research, nanomicelles loaded with Cur were formulated by a self-assembly method with biodegradable monomethoxy poly(ethylene glycol)-poly(lactide) copolymers (MPEG-PLAs). After encapsulation, the cellular uptake was increased and Cur could be released from MPEG-PLA micelles in a sustained manner. The Cur-loaded MPEG-PLA micelles (Cur/MPEG-PLA micelles) exhibited an enhanced toxicity on C6 and U251 glioma cells and induced more apoptosis on C6 glioma cells compared with free Cur. Moreover, the therapy efficiency of Cur/MPEG-PLA micelles was evaluated at length on a nude mouse model bearing glioma. The Cur/MPEG-PLA micelles were more effective on suppressing tumor growth compared with free Cur, which indicated that Cur/MPEG-PLA micelles improved the antiglioma activity of Cur in vivo. The results of immunohistochemical and immunofluorescent analysis indicated that the induction of apoptosis, antiangiogenesis, and inhibition of cell proliferation may contribute to the improvement in antiglioma effects. Our data suggested that Cur/MPEG-PLA may have potential clinic applications in glioma therapy. Keywords: curcumin, glioma, cell apoptosis, cell proliferation, angiogenesis
format	article
author	Zheng S Gao X Liu X Yu T Zheng T Wang Y You C
author_facet	Zheng S Gao X Liu X Yu T Zheng T Wang Y You C
author_sort	Zheng S
title	Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo
title_short	Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo
title_full	Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo
title_fullStr	Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo
title_full_unstemmed	Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo
title_sort	biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/3905e4fbe8bd472ea9f2eb493399ec47
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_version_	1718401541663096832

Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo

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