Diversity of Lipid Function in Atherogenesis: A Focus on Endothelial Mechanobiology

Atherosclerosis is one of the most important problems in modern medicine. Its high prevalence and social significance determine the need for a better understanding of the mechanisms of the disease’s development and progression. Lipid metabolism and its disorders are one of the key links in the patho...

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Autor principal:	Stanislav Kotlyarov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	atherosclerosis lipid metabolism endothelium mechanobiology cholesterol plasma membrane Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/390acd06c7b647768fe7bb242bb03fad
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id	oai:doaj.org-article:390acd06c7b647768fe7bb242bb03fad
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spelling	oai:doaj.org-article:390acd06c7b647768fe7bb242bb03fad2021-11-11T17:00:48ZDiversity of Lipid Function in Atherogenesis: A Focus on Endothelial Mechanobiology10.3390/ijms2221115451422-00671661-6596https://doaj.org/article/390acd06c7b647768fe7bb242bb03fad2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11545https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Atherosclerosis is one of the most important problems in modern medicine. Its high prevalence and social significance determine the need for a better understanding of the mechanisms of the disease’s development and progression. Lipid metabolism and its disorders are one of the key links in the pathogenesis of atherosclerosis. Lipids are involved in many processes, including those related to the mechanoreception of endothelial cells. The multifaceted role of lipids in endothelial mechanobiology and mechanisms of atherogenesis are discussed in this review. Endothelium is involved in ensuring adequate vascular hemodynamics, and changes in blood flow characteristics are detected by endothelial cells and affect their structure and function.Stanislav KotlyarovMDPI AGarticleatherosclerosislipid metabolismendotheliummechanobiologycholesterolplasma membraneBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11545, p 11545 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atherosclerosis lipid metabolism endothelium mechanobiology cholesterol plasma membrane Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	atherosclerosis lipid metabolism endothelium mechanobiology cholesterol plasma membrane Biology (General) QH301-705.5 Chemistry QD1-999 Stanislav Kotlyarov Diversity of Lipid Function in Atherogenesis: A Focus on Endothelial Mechanobiology
description	Atherosclerosis is one of the most important problems in modern medicine. Its high prevalence and social significance determine the need for a better understanding of the mechanisms of the disease’s development and progression. Lipid metabolism and its disorders are one of the key links in the pathogenesis of atherosclerosis. Lipids are involved in many processes, including those related to the mechanoreception of endothelial cells. The multifaceted role of lipids in endothelial mechanobiology and mechanisms of atherogenesis are discussed in this review. Endothelium is involved in ensuring adequate vascular hemodynamics, and changes in blood flow characteristics are detected by endothelial cells and affect their structure and function.
format	article
author	Stanislav Kotlyarov
author_facet	Stanislav Kotlyarov
author_sort	Stanislav Kotlyarov
title	Diversity of Lipid Function in Atherogenesis: A Focus on Endothelial Mechanobiology
title_short	Diversity of Lipid Function in Atherogenesis: A Focus on Endothelial Mechanobiology
title_full	Diversity of Lipid Function in Atherogenesis: A Focus on Endothelial Mechanobiology
title_fullStr	Diversity of Lipid Function in Atherogenesis: A Focus on Endothelial Mechanobiology
title_full_unstemmed	Diversity of Lipid Function in Atherogenesis: A Focus on Endothelial Mechanobiology
title_sort	diversity of lipid function in atherogenesis: a focus on endothelial mechanobiology
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/390acd06c7b647768fe7bb242bb03fad
work_keys_str_mv	AT stanislavkotlyarov diversityoflipidfunctioninatherogenesisafocusonendothelialmechanobiology
_version_	1718432170406576128

Diversity of Lipid Function in Atherogenesis: A Focus on Endothelial Mechanobiology

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