Association between diabetes complications and leukocyte counts in Iranian patients

Sedigheh Moradi1, Scott Reza Jafarian Kerman2, Farzaneh Rohani1, Fereshteh Salari21Endocrine and Metabolism Research Center (Firouzgar), Hemmat Campus, Tehran University of Medical Sciences, Tehran, Iran, 2Scientific Students Research Committee, Tehran University of Medical Sciences, Tehran, IranBac...

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Autores principales:	Moradi S, Kerman SRJ, Rohani F, Salari F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/390cc121265a41bdbd72ff0b1f51ccde
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spelling	oai:doaj.org-article:390cc121265a41bdbd72ff0b1f51ccde2021-12-02T07:24:43ZAssociation between diabetes complications and leukocyte counts in Iranian patients1178-7031https://doaj.org/article/390cc121265a41bdbd72ff0b1f51ccde2012-01-01T00:00:00Zhttp://www.dovepress.com/association-between-diabetes-complications-and-leukocyte-counts-in-ira-a9121https://doaj.org/toc/1178-7031Sedigheh Moradi1, Scott Reza Jafarian Kerman2, Farzaneh Rohani1, Fereshteh Salari21Endocrine and Metabolism Research Center (Firouzgar), Hemmat Campus, Tehran University of Medical Sciences, Tehran, Iran, 2Scientific Students Research Committee, Tehran University of Medical Sciences, Tehran, IranBackground: The long term complications of diabetes can be fatal. They are also renowned for being an economic burden. Previous studies have demonstrated a relationship between inflammatory markers and complications of diabetes. The objective of this study was to evaluate the relationship between leukocyte counts and these complications.Methods: The study included 184 patients diagnosed with type 2 diabetes. The study was carried out in Iran during 2007 and 2008. Data collected on the subjects were as follows: age, gender, weight, height, blood pressure, smoking history, lipid profile including low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol, triglycerides, and leukocyte count, albuminuria, and retinopathy. Furthermore, information on cardiac history for 100 patients was collected. The subjects were split into two groups according to their leukocyte levels: low (&le;7000/mm&sup3;) and high (&gt;7000/mm&sup3;); and then analyzed by Student&#39;s t-test or Mann&ndash;Whitney U-test as appropriate.Results: The average leukocyte count in these patients was 7594 &plusmn; 1965/mm&sup3;. Leukocyte count was significantly different in patients with and without retinopathy and albuminuria (P &lt; 0.0001). According to this analysis, a leukocyte count of 6750/mm&sup3; with a sensitivity of 80.2% and a specificity of 56.4%, and a count of 7550/mm&sup3; with a sensitivity of 63.2% and a specificity of 74.6% indicated at least one diabetes complication.Conclusion: An elevated leukocyte count even within the normal range was associated with chronic complications in type 2 diabetes.Keywords: leukocytes, diabetes complications, inflammationMoradi SKerman SRJRohani FSalari FDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2012, Iss default, Pp 7-11 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Moradi S Kerman SRJ Rohani F Salari F Association between diabetes complications and leukocyte counts in Iranian patients
description	Sedigheh Moradi1, Scott Reza Jafarian Kerman2, Farzaneh Rohani1, Fereshteh Salari21Endocrine and Metabolism Research Center (Firouzgar), Hemmat Campus, Tehran University of Medical Sciences, Tehran, Iran, 2Scientific Students Research Committee, Tehran University of Medical Sciences, Tehran, IranBackground: The long term complications of diabetes can be fatal. They are also renowned for being an economic burden. Previous studies have demonstrated a relationship between inflammatory markers and complications of diabetes. The objective of this study was to evaluate the relationship between leukocyte counts and these complications.Methods: The study included 184 patients diagnosed with type 2 diabetes. The study was carried out in Iran during 2007 and 2008. Data collected on the subjects were as follows: age, gender, weight, height, blood pressure, smoking history, lipid profile including low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol, triglycerides, and leukocyte count, albuminuria, and retinopathy. Furthermore, information on cardiac history for 100 patients was collected. The subjects were split into two groups according to their leukocyte levels: low (&le;7000/mm&sup3;) and high (&gt;7000/mm&sup3;); and then analyzed by Student&#39;s t-test or Mann&ndash;Whitney U-test as appropriate.Results: The average leukocyte count in these patients was 7594 &plusmn; 1965/mm&sup3;. Leukocyte count was significantly different in patients with and without retinopathy and albuminuria (P &lt; 0.0001). According to this analysis, a leukocyte count of 6750/mm&sup3; with a sensitivity of 80.2% and a specificity of 56.4%, and a count of 7550/mm&sup3; with a sensitivity of 63.2% and a specificity of 74.6% indicated at least one diabetes complication.Conclusion: An elevated leukocyte count even within the normal range was associated with chronic complications in type 2 diabetes.Keywords: leukocytes, diabetes complications, inflammation
format	article
author	Moradi S Kerman SRJ Rohani F Salari F
author_facet	Moradi S Kerman SRJ Rohani F Salari F
author_sort	Moradi S
title	Association between diabetes complications and leukocyte counts in Iranian patients
title_short	Association between diabetes complications and leukocyte counts in Iranian patients
title_full	Association between diabetes complications and leukocyte counts in Iranian patients
title_fullStr	Association between diabetes complications and leukocyte counts in Iranian patients
title_full_unstemmed	Association between diabetes complications and leukocyte counts in Iranian patients
title_sort	association between diabetes complications and leukocyte counts in iranian patients
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/390cc121265a41bdbd72ff0b1f51ccde
work_keys_str_mv	AT moradis associationbetweendiabetescomplicationsandleukocytecountsiniranianpatients AT kermansrj associationbetweendiabetescomplicationsandleukocytecountsiniranianpatients AT rohanif associationbetweendiabetescomplicationsandleukocytecountsiniranianpatients AT salarif associationbetweendiabetescomplicationsandleukocytecountsiniranianpatients
_version_	1718399451045822464

Association between diabetes complications and leukocyte counts in Iranian patients

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