Cytoprotective effects of cerium and selenium nanoparticles on heat-shocked human dermal fibroblasts: an in vitro evaluation

Bo Yuan, Thomas J Webster, Amit K Roy Chemical Engineering Department, College of Engineering, Northeastern University, Boston, MA, USA Abstract: It is a widely accepted fact that environmental factors affect cells by modulating the components of subcellular compartments and altering metabolic enz...

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Autores principales:	Yuan B, Webster TJ, Roy AK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	selenium ceria heat shock nanoparticles fibroblasts Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/390d4c99345a42ab9c3422d4bdddf8f8
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spelling	oai:doaj.org-article:390d4c99345a42ab9c3422d4bdddf8f82021-12-02T01:50:20ZCytoprotective effects of cerium and selenium nanoparticles on heat-shocked human dermal fibroblasts: an in vitro evaluation1178-2013https://doaj.org/article/390d4c99345a42ab9c3422d4bdddf8f82016-04-01T00:00:00Zhttps://www.dovepress.com/cytoprotective-effects-of-cerium-and-selenium-nanoparticles-on-heat-sh-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Bo Yuan, Thomas J Webster, Amit K Roy Chemical Engineering Department, College of Engineering, Northeastern University, Boston, MA, USA Abstract: It is a widely accepted fact that environmental factors affect cells by modulating the components of subcellular compartments and altering metabolic enzymes. Factors (such as oxidative stress and heat-shock-induced proteins and heat shock factors, which upregulate stress-response related genes to protect affected cells) are commonly altered during changes in environmental conditions. Studies by our group and others have shown that nanoparticles (NPs) are able to efficiently attenuate oxidative stress by penetrating into specific tissues or organs. Such findings warrant further investigation on the effects of NPs on heat-shock-induced stress, specifically in cells in the presence or absence (pretreated) of NPs. Here, we examined the cytoprotective effects of two different NPs (cerium and selenium) on heat-induced cell death for a model cell using dermal fibroblasts. We report for the first time that both ceria and selenium NPs (at 500 µg/mL) possess stress-relieving behavior on fibroblasts undergoing heat shock. Such results indicate the need to further develop these NPs as a novel treatment for heat shock. Keywords: ceria, heat shock, nanotechnology, cell death, nanomedicine, protectiveYuan BWebster TJRoy AKDove Medical Pressarticleseleniumceriaheat shocknanoparticlesfibroblastsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1427-1433 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	selenium ceria heat shock nanoparticles fibroblasts Medicine (General) R5-920
spellingShingle	selenium ceria heat shock nanoparticles fibroblasts Medicine (General) R5-920 Yuan B Webster TJ Roy AK Cytoprotective effects of cerium and selenium nanoparticles on heat-shocked human dermal fibroblasts: an in vitro evaluation
description	Bo Yuan, Thomas J Webster, Amit K Roy Chemical Engineering Department, College of Engineering, Northeastern University, Boston, MA, USA Abstract: It is a widely accepted fact that environmental factors affect cells by modulating the components of subcellular compartments and altering metabolic enzymes. Factors (such as oxidative stress and heat-shock-induced proteins and heat shock factors, which upregulate stress-response related genes to protect affected cells) are commonly altered during changes in environmental conditions. Studies by our group and others have shown that nanoparticles (NPs) are able to efficiently attenuate oxidative stress by penetrating into specific tissues or organs. Such findings warrant further investigation on the effects of NPs on heat-shock-induced stress, specifically in cells in the presence or absence (pretreated) of NPs. Here, we examined the cytoprotective effects of two different NPs (cerium and selenium) on heat-induced cell death for a model cell using dermal fibroblasts. We report for the first time that both ceria and selenium NPs (at 500 µg/mL) possess stress-relieving behavior on fibroblasts undergoing heat shock. Such results indicate the need to further develop these NPs as a novel treatment for heat shock. Keywords: ceria, heat shock, nanotechnology, cell death, nanomedicine, protective
format	article
author	Yuan B Webster TJ Roy AK
author_facet	Yuan B Webster TJ Roy AK
author_sort	Yuan B
title	Cytoprotective effects of cerium and selenium nanoparticles on heat-shocked human dermal fibroblasts: an in vitro evaluation
title_short	Cytoprotective effects of cerium and selenium nanoparticles on heat-shocked human dermal fibroblasts: an in vitro evaluation
title_full	Cytoprotective effects of cerium and selenium nanoparticles on heat-shocked human dermal fibroblasts: an in vitro evaluation
title_fullStr	Cytoprotective effects of cerium and selenium nanoparticles on heat-shocked human dermal fibroblasts: an in vitro evaluation
title_full_unstemmed	Cytoprotective effects of cerium and selenium nanoparticles on heat-shocked human dermal fibroblasts: an in vitro evaluation
title_sort	cytoprotective effects of cerium and selenium nanoparticles on heat-shocked human dermal fibroblasts: an in vitro evaluation
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/390d4c99345a42ab9c3422d4bdddf8f8
work_keys_str_mv	AT yuanb cytoprotectiveeffectsofceriumandseleniumnanoparticlesonheatshockedhumandermalfibroblastsaninvitroevaluation AT webstertj cytoprotectiveeffectsofceriumandseleniumnanoparticlesonheatshockedhumandermalfibroblastsaninvitroevaluation AT royak cytoprotectiveeffectsofceriumandseleniumnanoparticlesonheatshockedhumandermalfibroblastsaninvitroevaluation
_version_	1718402829114146816

Cytoprotective effects of cerium and selenium nanoparticles on heat-shocked human dermal fibroblasts: an in vitro evaluation

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